I rarely come on here or any social media, but wanted to share our latest preprint of large-scale human single neuron recordings during an auditory working memory task: doi.org/10.1101/2025... I'm very grateful to our patients, my co-authors and the funders. And to anyone who reads it :-) 🧠📈🧵👇(1/5)

We recorded single neurons while participants performed a task that involved keeping a simple tone in mind and then adjusting ongoing tones to match following a maintenance period of 3 seconds. We recorded a wide variety of regions, including hippocampus, cingulate, insula. (2/5)

Neurons in all the aforementioned regions (and others) showed modulation during the maintenance and adjustment phases of the task, with the highest proportion modulated in posterior hippocampus in the maintenance period. Strikingly, suppression was the dominant pattern of activity. (3/5)

State space analyses showed that task phases were clearly separable based on population activity, with neurons reaching an attractor-like state during maintenance and adjustment phases. Better task performance was associated with an increase in the number of neurons showing modulation. (4/5)