JAMA Oncology
JAMA Oncology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
🌐 JAMAOncology.com
- Individuals diagnosed with cancer in 2020 and 2021 had lower 1-year survival than before the pandemic, with greatest impact seen in older adults and non-Hispanic minority groups. bit.ly/3O7tgqe
- BrECADD produced better health-related quality of life than escalated BEACOPP in advanced-stage #HodgkinLymphoma, with fewer chemotherapy-related symptoms and improved functioning. bit.ly/4kg6BnT
- Individuals diagnosed with cancer in 2020 and 2021 had lower 1-year survival than before the pandemic, with greatest impact seen in older adults and non-Hispanic minority groups. bit.ly/3NUGpDa
- Low-dose aspirin in older adults was not associated with lower #Cancer incidence over 8.6 years, and cancer mortality risk did not persist beyond the exposure period. ja.ma/4tbKCm1
- This JAMA Oncology Patient Page describes the 3 main types of urinary diversions and care required after surgery to ensure an active and fulfilling life. ja.ma/4kcLt1v
- The addition of camrelizumab to chemotherapy produced statistically significant and clinically meaningful 5-year OS benefits compared with chemotherapy alone in the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma. ja.ma/4rti5Xn
- This JAMA Oncology Patient Page describes the 3 main types of urinary diversions and care required after surgery to ensure an active and fulfilling life. ja.ma/3M9hrPE
- Low-dose aspirin in older adults was not associated with lower #Cancer incidence over 8.6 years, and cancer mortality risk did not persist beyond the exposure period. ja.ma/45CqTll
- In active surveillance for #ProstateCancer, #MRI was most reliable for ruling out significant cancer in low PSA density cases but failed to achieve sufficient accuracy in broader populations. ja.ma/4rmlO95
- The addition of camrelizumab to chemotherapy produced statistically significant and clinically meaningful 5-year OS benefits compared with chemotherapy alone in the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma. ja.ma/3Z6xe4M
- In early 2025, the National Cancer Institute terminated 181 extramural grants, totaling more than $640 million in awards. Terminations targeted primarily basic science, general oncology, and early-career investigators. ja.ma/4k5WUIg
- Low-dose aspirin in older adults was not associated with lower #Cancer incidence over 8.6 years, and cancer mortality risk did not persist beyond the exposure period. ja.ma/3ZC5uoK
- For adults with metastatic HER2-positive #BiliaryTractCancer, zanidatamab led to longer overall survival and reduced pain, supporting its role as a precision therapy option. ja.ma/4rkG6jp
- Among patients with advanced urothelial cancer, upfront enfortumab vedotin dose reduction was linked to a 50% reduction in treatment interruption risk but did not compromise overall survival. ja.ma/49IUQma
- Semaglutide and tirzepatide prescriptions for obesity have increased among patients with preexisting cancer, with notable variation by cancer type and absence of cancer-specific guidelines. ja.ma/45vTlp1
- Cross-disciplinary international position statement summarizes the current understanding of CV toxic effects associated with ICI therapy, including strategies for diagnosis, treatment, and potential rechallenge and an outline of relevant knowledge gaps. ja.ma/46dCKGB
- In a nonrandomized phase 2 trial of adults with advanced dMMR/MSI-H noncolorectal cancers, combined nivolumab/ipilimumab showed an objective response rate of 63% and 6-month progression-free survival rate of 71%. ja.ma/4q05XMy
- Among women under 50, those with the highest ultraprocessed food intake had 45% higher odds of early-onset colorectal conventional adenomas versus those with the lowest intake; no significant association was seen for serrated lesions. ja.ma/4k1sBmc
- Phase 2 trial finds lorlatinib yielded a 73% objective response rate and median progression-free survival of 53.6 months in TKI-naive advanced ROS1-positive NSCLC. ja.ma/4qLLMDg
- 💬 Editorial: Metastatic recurrence nearly triples mortality risk in #BreastCancer among young adults and increases death risk in sarcoma and colorectal cancer—highlighting the need for earlier detection and novel treatments. ja.ma/4bgVhp4
- Among adolescents and young adults with #cancer, 9.5% of patients with earlier-stage cancer experienced metastatic recurrence within five years, with the highest rates in sarcoma (24.5%) and colorectal cancer (21.8%). ja.ma/4t4zYNZ
- Among patients with immune checkpoint inhibitor–related cutaneous adverse events, dupilumab therapy was associated with lower 5-year mortality compared to no dupilumab or systemic corticosteroids. ja.ma/4bMAM3y
- 💬 Viewpoint: The badscopal effect following ablative radiotherapy signals not failure but biological reorganization, prompting serial metastasis-directed therapy in selected patients. ja.ma/49Eqx04
- This Review outlines health gains and economic value, and identifies where future research, pricing reform, or prioritization are needed to support evidence-informed policymaking and sustainable use of immunotherapy in cancer treatment pathways. ja.ma/4sQoEVh
- The IMPACT tool accurately stratifies incidental meningioma patients by progression risk, supporting early intervention for high-risk, monitoring for medium-risk, and safe discharge for low-risk individuals. ja.ma/3NzjhK8
- Meta-analysis: Among patients with intermediate-, high-, or very high-risk prostate cancer, the ideal duration of ADT with radiotherapy demonstrated nonlinear benefits, with diminished gains after 12 months and variation in benefit by risk group. ja.ma/4qreCZj
- 💬 Viewpoint: #Medicaid cuts and work requirements in the 2025 budget law risk reduced access to cancer prevention, delayed diagnoses, later-stage disease at presentation, and caused worse cancer outcomes. ja.ma/4sJGxp3
- The 2025 federal #Medicaid restrictions are projected to cause over 1 million missed #CancerScreening exams and over 150 excess #cancer deaths within 2 years, with substantial impact on younger and vulnerable adults. ja.ma/49HWmnb
- CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/3LxmMjH
- Among women under 50, those with the highest ultraprocessed food intake had 45% higher odds of early-onset colorectal conventional adenomas versus those with the lowest intake; no significant association was seen for serrated lesions. ja.ma/45NVso6
- Guideline-adherent lymph node dissection provided a small survival benefit for patients with high-grade or no lepidic pattern #LungAdenocarcinoma, but not for those with lepidic pattern alone. ja.ma/49sfVkM
- In a nonrandomized phase 2 trial of adults with advanced dMMR/MSI-H noncolorectal cancers, combined nivolumab/ipilimumab showed an objective response rate of 63% and 6-month progression-free survival rate of 71%. ja.ma/4qYodXt
- Guideline-adherent lymph node dissection provided a small survival benefit for patients with high-grade or no lepidic pattern #LungAdenocarcinoma, but not for those with lepidic pattern alone. ja.ma/4b4i6w6
- Older age in unrelated donors linked to lower survival in allogeneic hematopoietic cell transplant with conventional calcineurin inhibitor-based graft-vs-host disease prophylaxis, but this association is mitigated with posttransplant cyclophosphamide. ja.ma/3YJMpAI
- Incidentally detected spleen length ≥140 mm or volume ≥500 mL was associated with markedly elevated 5-year risk for hematologic cancer, liver cancer, and cirrhosis in adults from Denmark and the UK. ja.ma/4jG4ARo
- Guideline-adherent lymph node dissection provided a small survival benefit for patients with high-grade or no lepidic pattern #LungAdenocarcinoma, but not for those with lepidic pattern alone. ja.ma/49BVIrh
- The 2025 federal #Medicaid restrictions are projected to cause over 1 million missed #CancerScreening exams and over 150 excess #cancer deaths within 2 years, with substantial impact on younger and vulnerable adults. ja.ma/49waPmf
- Among men with #ProstateCancer undergoing hormone therapy, #SGLT2 inhibitor use was associated with lower risk of treatment failure and delayed progression compared with nonuse, supporting potential adjunctive benefit. ja.ma/4jzyDtZ
- CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/3N9Any2
- Gastric cancer is the fifth most diagnosed #cancer and the fifth leading cause of cancer-related deaths worldwide. This @jama.com Review summarizes the epidemiology, pathophysiology, diagnosis, and management of #GastricCancer. ja.ma/4aO8sxp
- Among patients with advanced urothelial cancer, upfront enfortumab vedotin dose reduction was linked to a 50% reduction in treatment interruption risk but did not compromise overall survival. ja.ma/3YnPJkQ
- Meta-analysis: Among patients with intermediate-, high-, or very high-risk prostate cancer, the ideal duration of ADT with radiotherapy demonstrated nonlinear benefits, with diminished gains after 12 months and variation in benefit by risk group. ja.ma/4ppJBUq
- Ocular toxic effects including keratopathy, blurred vision, cataract progression, and uveitis were common but generally reversible during mirvetuximab soravtansine therapy for FRα-positive gynecologic cancers. ja.ma/49mr6tQ
- Sarcomas comprise a heterogeneous group of malignant neoplasms that include genomically simple and genomically complex subtypes. This consensus provides guidelines for efficient, rational use of next-generation sequencing in their clinical management. ja.ma/3MWrtE9
- A 52-year-old woman had presented with persistent inflammatory edema of the lower limb and a history of squamous cell #carcinoma. What is your diagnosis? ja.ma/4bmRVAC
- Editorial: MELATORCH trial supports PD-1 blockade as standard care over chemotherapy for advanced acral melanoma, yet limited long-term benefit signals the need for novel therapeutic strategies. ja.ma/4jejiyP
- In a phase 3 trial, toripalimab improved progression-free survival over dacarbazine as first-line treatment in advanced #melanoma predominantly of acral subtype, with an acceptable safety profile. ja.ma/4pkD2Ci
- Sarcomas comprise a heterogeneous group of malignant neoplasms that include genomically simple and genomically complex subtypes. This consensus provides guidelines for efficient, rational use of next-generation sequencing in their clinical management. ja.ma/4pir6Rs
- Dexrazoxane use in pediatric AML rose from 0.5% to 98.5% between 2010 and 2021, coinciding with a 50% reduction in ICU-level cardiovascular care, supporting rapid adoption of dexrazoxane for cardioprotection with intensive chemotherapy. ja.ma/4bdtHc4
- Cribriform morphology predicted 15-year metastasis in #ProstateCancer, with radiotherapy plus neoadjuvant ADT reducing this risk, while cribriform-negative patients did not benefit from early radical treatment for metastasis prevention. ja.ma/4pm5W5h
