JAMA Dermatology
JAMA Dermatology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
🌐 JAMADermatology.com
- 📄 This case report describes large areas of erythema on the face, chest, and back with relatively clear boundaries and swollen hands with scattered skin-colored papules and nodules. bit.ly/3ZgXYQe
- In a nationwide French cohort, antibiotic exposure was associated with an increased risk of discontinuation of biologic therapies in psoriasis. bit.ly/46mkYkA
- This systematic review and analysis of genotype-phenotype correlations in dystrophic epidermolysis bullosa reinforces known associations, identified novel variant hotspots, and highlights potential therapeutic targets. bit.ly/4tjXF4L
- This case report describes a patient with a history of refractory acute myeloid leukemia who presented with white, spiny hyperkeratotic papules on his face and neck, and was subsequently diagnosed with trichodysplasia spinulosa. bit.ly/4tjXhDl
- Agent Orange exposure was associated with increased risk of acral melanoma among US veterans, supporting the need for research into environmental factors in melanoma risk. ja.ma/46wY0Hw
- 💬 Editorial: A case-control study in US Vietnam veterans indicates a modest increased risk for #AcralMelanoma associated with presumptive Agent Orange exposure, but actual case numbers are low due to the cancer’s rarity. ja.ma/4r2Wq8E
- This case report describes a woman in her 30s with porcelain-white discoloration of all nails, which persisted under pressure, and a GJA1 mutation. ja.ma/4bAdsGh
- 💬 Editor's Note: Botulinum toxin injections appear safe and highly effective for acute digital ischemia and ulcers, particularly in systemic sclerosis and autoimmune vasculopathies, with minimal adverse events reported. ja.ma/4a7jTy3
- Patients with #acne were less likely to have a relapse if they received a higher total dose of #isotretinoin, while daily dose did not make a difference in recurrence rates. 📽️ Watch the video and learn more: ja.ma/3NU4lGH
- Use of immunostimulatory herbs prior to dermatomyositis onset is linked to lower rates of myositis-specific, myositis-associated, and antinuclear autoantibody positivity. ja.ma/4bP391p
- Among patients with juvenile localized scleroderma, mycophenolate mofetil and methotrexate showed comparable efficacy, but mycophenolate mofetil had improved tolerability. ja.ma/4rmmfAf
- Among patients with juvenile localized scleroderma, mycophenolate mofetil and methotrexate showed comparable efficacy, but mycophenolate mofetil had improved tolerability. ja.ma/46qcHvZ
- Among patients with chronic pruritus, sleep problems contributed more to daily functional impairment and were most significant in pruriceptive itch. ja.ma/4k2sXsC
- Botulinum toxin injections were associated with high complete response rates for acute digital ischemia (93.1%), ischemic ulcers (90.1%), and gangrene (87.5%), with minimal adverse events. ja.ma/4rqaCs9
- A neonate presents with a 1-day history of 15 discrete 2- to 10-mm tense and flaccid yellow vesicles and bullae on the chest, arms, and legs as well as subtle flexural erythema but is otherwise well appearing. What is your diagnosis? ja.ma/4bWqtdk
- Seven #HidradenitisSuppurativa–specific patient-reported outcome measures met COSMIN criteria for sufficient validity, with HiSQOL-17 rated strongest for reliability and responsiveness. ja.ma/46pSEhc
- In adults with biopsy-proven small vessel vasculitis of the skin, nausea/vomiting, abdominal pain, ulcerating/necrotic lesions, fatigue, & dipstick hematuria were linked to increased risk of systemic disease. ja.ma/3NWP4Vu
- Incidence rates of cutaneous squamous cell #carcinoma and carcinoma in situ increased in Denmark from 2005 to 2023, with sex and site-specific patterns and declining keratoacanthoma rates. ja.ma/3Ocv7di
- JAK2 fusions in cutaneous T-cell lymphomas are present in both aggressive and indolent disease, including patients with early-stage mycosis fungoides and CD30-positive lymphoproliferative disorders. ja.ma/4q1FVIv
- Among patients with juvenile localized scleroderma, mycophenolate mofetil and methotrexate showed comparable efficacy, but mycophenolate mofetil had improved tolerability. ja.ma/4q8QHge
- 💬 Editorial: Novel next-generation sequencing (NGS) techniques are transforming CTCL diagnosis and management, enabling more sensitive detection, quantification of clonal burden, and prognostic stratification beyond traditional PCR-based assays. ja.ma/4sX9FZQ
- Seven #HidradenitisSuppurativa–specific patient-reported outcome measures met COSMIN criteria for sufficient validity, with HiSQOL-17 rated strongest for reliability and responsiveness. ja.ma/4t12RdK
- Lupuslike manifestations associated with myelodysplastic syndromes or chronic myelomonocytic leukemia presented distinct features from idiopathic lupus, including older age, male predominance, and limited kidney or joint involvement. ja.ma/462GdYA
- Case report describes a patient with a postzygotic FGFR3 p.Ser249Cys variant presenting with acanthosis nigricans, generalized epidermal nevus, and features of severe achondroplasia with developmental delay. ja.ma/49KgOW4
- Survivors of Stevens-Johnson syndrome and toxic epidermal necrolysis reported long-term biopsychosocial impacts, including chronic physical symptoms, mental health challenges, and medical distrust along with critical gaps in care. ja.ma/3O5BQ8Q
- JAK inhibitor exposure was not associated with reduced height in children treated for atopic dermatitis, juvenile arthritis, or inflammatory bowel disease. ja.ma/4bAXdZN
- Among adults with #AtopicDermatitis, JAK inhibitor use was associated with more than double the 6-month risk of physician-recorded #Acne compared with Th2 cytokine inhibitor, with no difference seen for folliculitis or rosacea. ja.ma/4sYz6dt
- #Acne prevalence among transmasculine patients ranged from 29.6% to 61.9% depending on methodology. 📌 This Review aims to summarize current literature for prevalence and factors associated with acne in transmasculine patients. ja.ma/49D2xKz
- This case report describes a man in his 30s who was referred for the evaluation of a 3-month destructive process affecting the nail matrix and nail plate of the left thumbnail. ja.ma/3NssHat
- Seborrheic #dermatitis in adults is positively associated with a range of other epithelial barrier diseases, including atopic dermatitis, #psoriasis, #rosacea, #celiac disease, and dry eye. ja.ma/49Mg7dq
- Moderate to severe #Acne incidence was greatest within the first year after testosterone for transmasculine individuals vs cisgender comparators. ja.ma/3ZucdRy
- Specific T-cell receptor clonotypes, especially Vb20 and Vg8, were associated with advanced-stage disease and poor survival in MF/SS. ja.ma/4abQiE3
- Discordance between clinician- and patient-reported outcomes is common in Skin Chronic Graft-vs-Host Disease. Ade Adamson, MD, speaks with author Emily Baumrin, MD, MSCE, about how patient-reported measures may better predict survival. Listen now: ja.ma/49M1vdV
- In cutaneous cutaneous chronic graft-vs-host disease, discordance in clinician vs patient treatment response was common, especially in sclerotic disease; both measures were independently associated with survival. ja.ma/3LEPsY4
- Once-daily oral ICP-332, a tyrosine kinase 2 inhibitor, showed favorable safety and significantly improved disease severity versus placebo in adults with moderate to severe #AtopicDermatitis. ja.ma/45ZPrET
- In this episode of the JAMA Dermatology Author Interviews podcast, Arash Mostaghimi, MD, MPH, discusses trends in advanced practice clinician involvement and specialty drug spending in dermatology with host Ade Adamson, MD, MPP. 🎧 Listen now: ja.ma/3LR4Ssa
- Between 2013 and 2022, the share of #Dermatology specialty drug spending by advanced practice clinicians rose from 10% to 31%, driven by a faster increase in APC numbers and prescribing intensity compared to physicians. ja.ma/3NmRblg
- Activating #EGFR variants were identified in early-onset, severe generalized #AcanthosisNigricans with pulmonary nodules; EGFR inhibitor therapy improved both skin and lung disease. ja.ma/4bw0Rnp
- Once-daily oral ICP-332, a tyrosine kinase 2 inhibitor, showed favorable safety and significantly improved disease severity versus placebo in adults with moderate to severe #AtopicDermatitis. ja.ma/4qRwGeK
- Eosinophilic fasciitis (EF) is a rare disease in which the fascia, the tissue that covers the muscles, becomes inflamed. 📄 This Patient Page describes the symptoms, diagnosis, and treatment of eosinophilic fasciitis. ja.ma/456KTwd
- Case report describes a patient in his 50s with immunoglobulin A vasculitis with monoclonal B-cell lymphocytosis who was successfully treated with zanubrutinib after failure of multiple treatments. ja.ma/49HVRuF
- An adolescent female presented with 3 days of progressive abdominal pain and reported that a rash first appeared nearly 1 year earlier on her left wrist and gradually spread over several weeks. What is your diagnosis? ja.ma/4qItEcH
- Transcutaneous auricular vagus nerve stimulation improved facial erythema, flushing, and related systemic symptoms among patients with patients with erythematotelangiectatic #rosacea compared to sham treatment. ja.ma/3Z01e20
- Systematic review: Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. ja.ma/4qANZRk
- Among bionaive patients with #Psoriasis in Denmark, ustekinumab had superior drug survival compared with adalimumab and secukinumab over 5 years. ja.ma/45kP3AP
- A woman in her 70s presented with a 5-year history of pruritic, thickened plaques involving the trunk and extremities. Despite intermittent treatment with antihistamines and glucocorticoids, the condition progressed. Read the full case report: ja.ma/49kbXJD
- Psoriasis patients treated with ustekinumab had a lower five-year risk of developing cancer (excluding nonmelanoma skin cancer) compared to those on adalimumab, while risk for secukinumab was similar but limited by small sample size. ja.ma/49ooiMZ
- Acne keloidalis nuchae (AKN) is a chronic skin condition characterized by inflamed hair follicles that can cause hair loss and substantial scarring. This Patient Page describes the symptoms, diagnosis, and treatment of AKN. ja.ma/4bfbuuD
- Lamellar ichthyosis (LI) is a rare autosomal recessive disorder characterized by widespread, thick, platelike scales. This case report describes 2 siblings in their 20s with lamellar ichthyosis treated with acitretin and dupilumab. ja.ma/45mH99S
- The EBSdart scoring tool reliably measures disease severity in epidermolysis bullosa simplex across age groups, showing strong interrater agreement and generalizability, and may aid future clinical trials and therapy development. ja.ma/49j9KhF
