José Aguilar-Rodríguez
Evolutionary systems/cell biologist. EMBO and SNSF Postdoctoral Fellow with Dmitri Petrov and Dan Jarosz at Stanford. PhD with Andreas Wagner at the University of Zurich. Studying how molecular and cellular systems shape, and are shaped by, evolution.
- Reposted by José Aguilar-RodríguezRegistration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social
- Reposted by José Aguilar-RodríguezSuper excited about our schedule for BAPG at stanford on Dec 6. bapg2025.github.io/bapg2025stan... Amazing talks, a fabulous keynote, a lively poster session. A brilliant and interactive community. What’s not to love? 1/2 @sophiejwalton.bsky.social
- Reposted by José Aguilar-RodríguezSubmit an abstract to our symposium "S20 Mapping fitness landscapes with mechanistic models, machine learning and experiments" 🧬 - organised with @meikewortel.bsky.social
- Abstract submission & Award applications for SMBE 2026 are now open! Submit your research and apply for SMBE awards via the submission portal. 📝 Read more & submit here: smbe2026.org/abstracts And symposium selection is now finalized! 👉 See all accepted symposia: smbe2026.org/programme #SMBE2026
- Reposted by José Aguilar-RodríguezI'm excited to present this new model to detect positive selection on regulatory sequences, which has been 3 years in the making! Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃 doi.org/10.1101/2025.11.26.… […] [Original post on ecoevo.social]
- Excited to co-organize with @weieli.bsky.social a symposium at SMBE 2026 on how synthetic & systems biology can illuminate the molecular mechanisms of evolution. Honored to have @christianlandry.bsky.social as invited speaker! Join us!
- SMBE2026 Symposium 6 | Synthetic and systems biology approaches to dissecting the molecular mechanisms of evolution 📨 Abstract submission smbe2026.org/abstracts 📋 Programme details smbe2026.org/programme #SMBE2026
- With recent advances in genome engineering, high-throughput fitness and phenotype assays, and experimental evolution, we’re entering an exciting new era of empirical evolutionary biology—one where evolutionary hypotheses can be tested with unprecedented scale, precision, and mechanistic depth.
- Reposted by José Aguilar-RodríguezThrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...
- Reposted by José Aguilar-RodríguezSuper excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n) www.biorxiv.org/content/10.1...
- Reposted by José Aguilar-RodríguezWe have an open PhD position (application deadline 9 January 2026) in "Theory of fitness landscapes" at @unibe.ch 🤓⛰️📊👩💻🎓: banklab.github.io/positions/ Please share widely! #QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
- Reposted by José Aguilar-Rodríguez
- Reposted by José Aguilar-RodríguezNew paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...
- Reposted by José Aguilar-RodríguezThis is a beautiful study. Congrats Jose and all authors!
- One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...
- Reposted by José Aguilar-RodríguezCheck out @jaguilarrod.bsky.social and @petrovadmitri.bsky.social thought provoking work! If like me, you feel this work may be out of your comfort zone, make sure to read Jose's bluetorial, clearly explained! Congratulations!
- One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...
- Reposted by José Aguilar-RodríguezMy lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
- Reposted by José Aguilar-RodríguezTerrific work! 👏👏
- Reposted by José Aguilar-RodríguezWow! Very impressive work 🤯
- Reposted by José Aguilar-Rodríguez1/5 🦖 Michael Crichton’s Jurassic Park (1990) turns 35 in November. In a new preprint, I argue that it was a prescient meditation on evolutionary genetics, complexity, & control. I also examine analogous efforts of today (e.g. “de-extinction.") Select points below: ecoevorxiv.org/repository/v...
- Reposted by José Aguilar-RodríguezA fun little side project I've been working on with @stepadenisov.bsky.social , Mato Lagator, and Andreas Wagner: "Strong promoters are mutationally robust". Briefly... www.biorxiv.org/content/10.1...
- Reposted by José Aguilar-RodríguezI am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social www.cell.com/cell/fulltex...
- Reposted by José Aguilar-RodríguezToday in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
- Reposted by José Aguilar-RodríguezThis paper is SO COOL! Congrats, and thanks for sharing!
- Reposted by José Aguilar-RodríguezI’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication. I’m recruiting PhD students to start in the first semester of 2026. Apply via EPFL PhD programs by Nov 1 drive.google.com/file/d/1cm-t...
- Reposted by José Aguilar-RodríguezWhat a cool paper. Also note that this very careful analysis does not support the majority of synonymous variants being non-neutral in yeast
- One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...
