Sharper footprints, cleaner insights? Yuxuan Lin at the University of Pennsylvania explores a new approach that corrects Tn5 bias for bulk & single-cell ATAC-seq, boosting the accuracy of transcription-factor binding 🔬
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www.biorxiv.org/content/10.1...
#SingleCell #Epigenomics #ATACseq
Robust footprinting with sample-specific Tn5 bias correction for bulk and single cell ATAC-seq
Footprint analysis of assay for transposase-accessible chromatin via sequencing (ATAC-seq) enables base resolution mapping of regulatory elements but is often underpowered and prone to false positives...
