The Interactive Fly
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
- Huang, Y. C., Costa, C. A. M., Ruiz, N. V., Wang, X., Jevitt, A., Breneman, C. M., Han, C., Deng, W. M. (2025). Polyploidy promotes transformation of epithelial cells into non-professional phagocytes. bioRxiv, www.biorxiv.org/content/10.1...
- Singh, J., Verma, D., Sarkar, B., Paul, M., Mutsuddi, M., Mukherjee, A. (2025). Notch and LIM-homeodomain protein Arrowhead regulate each other in a feedback mechanism to play a role in wing and neuronal development in Drosophila. Open Biol, 15(4):240247 royalsocietypublishing.org/rsob/article...
- Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...
- Zhao, Y., Alexandre, C., Kelly, G., Vincent, J. P., Perez-Mockus, G. (2025). HIF-1alpha-mediated feedback prevents TOR signalling from depleting oxygen supply and triggering stress during normal development. Nat Commun, www.nature.com/articles/s41...
- Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...
- Ahrentlov, N., Kubrak, O., Lassen, M., ...., Nagy, S., Imig, C., Richter, E. A., Texada, M. J., Rewitz, K. (2025). Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan. Nat Metab, 7(6):1223-1245 www.nature.com/articles/s42...
- Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 pubmed.ncbi.nlm.nih.gov/40178596/
- Hey, J., Pavinato, V. A. C. (2025). Isolating selective from non-selective forces using site frequency ratios. PLoS Genet, 21(4):e1011427 journals.plos.org/plosgenetics...
- Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 link.springer.com/article/10.1...
- Lai, W. Y., Hsu, S. K., Futschik, A., Schlotterer, C. (2025). Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation. Elife, 13 elifesciences.org/articles/102...
- Glaser-Schmitt, A., Lebherz, M., Saydam, E., Bornberg-Bauer, E., Parsch, J. (2025). Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster onlinelibrary.wiley.com/doi/10.1002/...
- Hey, J., Pavinato, V. A. C. (2025). Isolating selective from non-selective forces using site frequency ratios. PLoS Genet, 21(4):e1011427 journals.plos.org/plosgenetics...
- Audet, T., Wilson, A., Dukas, R., Dworkin, I. (2025). he role of resource defensibility in facilitating sexually-selected weapon evolution: An experimental evolution test. Evolution, academic.oup.com/evolut/artic...
- Arnce, L. R., Bubnell, J. E., Aquadro, C. F. (2025). omparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution. J Mol Evol, 93(2):278-291 link.springer.com/article/10.1...
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- Huang, Y. C., Costa, C. A. M., Ruiz, N. V., Wang, X., Jevitt, A., Breneman, C. M., Han, C., Deng, W. M. (2025). Polyploidy promotes transformation of epithelial cells into non-professional phagocytes. bioRxiv, www.biorxiv.org/content/10.1...
- Singh, J., Verma, D., Sarkar, B., Paul, M., Mutsuddi, M., Mukherjee, A. (2025). Notch and LIM-homeodomain protein Arrowhead regulate each other in a feedback mechanism to play a role in wing and neuronal development in Drosophila. Open Biol, 15(4):240247 royalsocietypublishing.org/rsob/article...
- Fujinaga, D., Nolan, C., Yamanaka, N. (2025). Functional characterization of eicosanoid signaling in Drosophila development. PLoS Genet, 21(5):e1011705 journals.plos.org/plosgenetics...
- Medina, A. B., Perochon, J., Tian, Y., Johnson, C. T., Holcombe, J., Ramesh, P., Polcownuk, S., Yu, Y., Cordero, J. B. (2025). Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila. Dev Cell, 60(22):3085-3101 www.cell.com/developmenta...
- Ahrentlov, N., Kubrak, O., Lassen, M., Malita, A., Koyama, T., ...., Nagy, S., Imig, C., Richter, E. A., Texada, M. J., Rewitz, K. (2025). Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan. Nat Metab, 7(6):1223-1245 www.nature.com/articles/s42...
- Evdokimova, A. A., Kolesnikova, T. D., Mazina, M. Y., ...., Vorobyeva, N. E. (2025). Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Nucleic Acids Res, 53(7) pmc.ncbi.nlm.nih.gov/articles/PMC...
- Evdokimova, A. A., Kolesnikova, T. D., Mazina, M. Y., ...., Vorobyeva, N. E. (2025). Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Nucleic Acids Res, 53(7) pmc.ncbi.nlm.nih.gov/articles/PMC...
- Dahn, S., Wagner, A. E. (2025). Drosophila melanogaster as a model organism to investigate sex specific differences. Sci Rep, 15(1):19648 www.nature.com/articles/s41...
- Sun, Y., Shui, K., Li, Q., Liu, C., Jin, W., Ni, J. Q., Lu, J., Zhang, L. (2025). Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep. PLoS Biol, 23(5):e3003173 journals.plos.org/plosbiology/...
- Fallacaro, S., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M. (2025). Transcription factor hubs exhibit gene-specific properties that tune expression. bioRxiv, www.biorxiv.org/content/10.1...
- Kemp, J. P., Jr., Geisler, M. S., Hoover, M., Cho, C. Y., O'Farrell, P. H., Marzluff, W. F., Duronio, R. J. (2025). Cell-cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes. Mol Biol Cell, 36(7):ar88 www.molbiolcell.org/doi/10.1091/...
- Chatsirisupachai, K., Moene, C. J. I., Kleinendorst, R., Kreibich, E., Molina, N., Krebs, A. (2025). Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II. Mol Syst Biol, 21(5):447-471 link.springer.com/article/10.1...
- Reposted by The Interactive FlyThe initiator #caspase Dronc can trigger compensatory #apoptosis -induced proliferation (AiP). This study shows that Dronc-dependent Ca2+ influx into the cytosol is an important contributor to AiP & DUOX activation in #Drosophila (& likely in vertebrates) @plosbiology.org 🧪 plos.io/4pNG4PK
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- Villalobos-Cantor, S., Arreola-Bustos, A., Martin, I. (2025). Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila. Genetics, 230(3) academic.oup.com/genetics/art...
- Adebambo, T. H., Medina-Flores, F., Zhang, S., Lerit, D. A. (2025). Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model. G3 (Bethesda), 15(5) academic.oup.com/g3journal/ar...
- Bhatnagar, A., Thomas, C. M., Nge, G. G., Zaya, A., Dasari, R., Chongtham, N., Manandhar, B., Kortagere, S., Elefant, F. (2025). Tip60 HAT activators as therapeutic modulators for Alzheimer's disease. Nat Commun, 16(1):3347 www.nature.com/articles/s41...
- Yan, J., Feng, C., Zhang, H., Luo, T., Chen, H., Chen, H. (2025). Dapagliflozin ameliorates intestinal stem cell aging by regulating the MAPK signaling pathway in Drosophila. Front Cell Dev Biol, 13:1576258 www.frontiersin.org/journals/cel...
- Philyaw, T. J., Titos, I., Cummins-Beebee, P. N., Rodan, A. R., Rothenfluh, A. (2025). Bitter Sensing Protects Drosophila from Developing Experience-Dependent Cocaine Consumption Preference. J Neurosci, 45(27) www.jneurosci.org/content/45/2...
- Macartney, E. L., Burke, S., Pottier, P., ...., Neely, G. G., Drobniak, S. M., Nakagawa, S. (2025). Sex-Specific Effects of Social Environment on Behaviour and Their Correlations in Drosophila melanogaster. Ecol Evol, 15(4):e71261 onlinelibrary.wiley.com/doi/10.1002/...
- Wu, Z., Wu, X., Wang, Z., Ye, X.,....,Drezen, J. M., Strand, M. R., Chen, X. (2025). A symbiotic gene stimulates aggressive behavior favoring the survi val of parasitized caterpillars. Proc Natl Acad Sci U S A, 122(18):e2422935122 www.pnas.org/doi/10.1073/...
- Vaxenburg, R., Siwanowicz, I., Merel, J., ...., Reiser, M. B., Botvinick, M. M., Branson, K. M., Tassa, Y., Turaga, S. C. (2025). Whole-body physics simulation of fruit fly locomotion. Nature, www.nature.com/articles/s41...
- Yoshino, J., Mali, S. S., Williams, C. R., ..., Ishii, K., Emoto, K., Bautista, D. M., Parrish, J. Z. (2025). Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. Elife, 13https://elifesciences.org/articles/95379
- Wang, C., Shen, J. (2025). From metabolism to lifespan trade-offs: polyethylene microplastics induce circadian disruption and sex-specific aging in Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol, 295:110214 www.sciencedirect.com/science/arti...
- Rossano, A., Zhang, L., ..., Mount, D., Romero, M. F. (2025). Ex vivo quantification of intracellular pH in Drosophila Malpighian tubule reveals basolateral HCO(3) (-)/oxalate exchange through a novel oxalate transporter "Neat". Front Physiol, 16:1468451 www.frontiersin.org/journals/phy...
- Rai, M., Li, H., Policastro, R. A., Pepin, R., Zentner, G. E., Nemkov, T., D'Alessandro, A., Tennessen, J. M. (2025). Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3. PLoS Genet, 21(5):e1011690 journals.plos.org/plosgenetics...
- Van De Poll, M. N., van Swinderen, B. (2025). Long-term multichannel recordings in Drosophila flies reveal altered predictive processing during sleep compared with wake. J Exp Biol, 228(11) journals.biologists.com/jeb/article/...
- Yu, G., Yang, Q., Wu, Q. (2025). Rapamycin Alters the Feeding Preference for Amino Acids and Sugar in Female Drosophila. J Gerontol A Biol Sci Med Sci, 80(7) academic.oup.com/biomedgeront...
- Subaric, D., Rastija, V., Karnas Babi , M., Agic, D., Majic, I. (2025). Structural Features of Coumarin-1,2,4-Triazole Hybrids Important for Insecticidal Effects Against Drosophila melanogaster and Orius laevigatus (Fieber). Molecules, 30(8 www.mdpi.com/1420-3049/30...
- Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
- Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
- Scudese, E., Marshall, A. G., Vue, Z., Exil, V., ..., Sharma, V., Mobley, B. C., Katti, P., Hinton, A. (2025). 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes. Aging Cell:e70054 onlinelibrary.wiley.com/doi/10.1111/...
- Tan, S. L., Neumann, D., Trim, P. J., ...., O'Keefe, L. V., Hemsley, K. M., Lau, A. A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Mol Genet Metab, 145(2):109112 www.sciencedirect.com/science/arti...
- Singh, K., Gupta, K., Shukla, S., Kumari, A. P., Kumar, A. (2025). Repurposing Oseltamivir Against CAG Repeat Mediated Toxicity in Huntington's Disease and Spinocerebellar Ataxia Using Cellular and Drosophila Model. ACS Omega, 10(15):14980-14993 pmc.ncbi.nlm.nih.gov/articles/PMC...
- Song, H., Kim, S., Han, J. E., Kang, K. H., Koh, H. (2025). PDH Inhibition in Drosophila Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models. Biomedicines, 13(4) www.mdpi.com/2227-9059/13...
- Serebryany-Piavsky, V., Egulsky, L., Manoim-Wolkovitz, J. E., Anis, S., Hassin-Baer, S., Parnas, M., Horowitz, M. (2025). The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease. Hum Mol Genet, 34(14):1184-1203 academic.oup.com/hmg/article/...
- Lee, U., Li, C., Langer, C. B., Svetec, N., Zhao, L. (2025). Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination. Proc Natl Acad Sci U S A, 122(18):e2425618122 www.pnas.org/doi/10.1073/...
- Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
