Recently in
#Science #Immunology: researchers @ Weizmann & Tel Aviv Sourasky characterize synovial fluid immune compartment of
#PsoriaticArthritis patients.
#Immunoproteasome- &
#MHCI -related genes ↑ in patients w refractory disease. Targeting immunoproteasome may be possible therapeutic approach!
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance
Refractory PsA patients exhibit dysregulated immunoproteasome and MHC-I machinery, highlighting potential therapeutic targets.
