- Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠 www.nature.com/articles/s41...
- Each day, humans shed billons of host cells from the gut lining out of the body (our "exfoliome") via our poop. Foli-seq unlocks this non-invasive exfoliome analysis to assess gut and immune functions, and links with the gut microbiome, all w/o colonoscopy or tissue biopsy. 💩🧬Nov 17, 2025 20:55
- In 💩 samples from patients with Inflammatory Bowel Disease (IBD) from the @crohnscolitisfdn.bsky.social, we can distinguish different patient cohorts with increase clinical severity of disease and stratifying biomarkers that associated with immune pathway involvement.
- We are excited for many apps of Foli-seq in academia & industry. Please reach out to collaborate! Lots of exciting projects in this space for students & postdocs. Led by Yiming @yiminghuang.bsky.social and Yiwei @yiweisun.bsky.social & thanks to all our collaborators! @columbiasysbio.bsky.social
