Hamilton Lab @ VCU
Using synthetic biology to reveal how the brain adapts to drug use and stress experience.
hamilton-lab.weebly.com
- In a recent pub, grad students Kijoon and Corinne co-led a study where we made molecular tools to manipulate transposable elements (TEs) in mouse prefrontal cortex. We saw that transcriptional escape of brain TEs uniquely impaired complex social behavior. Read it here: www.pnas.org/doi/10.1073/...
- Reposted by Hamilton Lab @ VCU[Not loaded yet]
- Reposted by Hamilton Lab @ VCU
[This post could not be retrieved] - In a new paper, we analyze published RNAseq and discover impact to the expression of transposable element transcripts in the brains of people with major depressive disorder. Natalie Truby, a recent-grad from the lab, spearheaded this work. Read about it here: doi.org/10.1016/j.ja...
- In this preprint, grad students Kijoon Kim and Corinne Smith re-programmed the function of the KZFP-interacting protein TRIM28. We discover that TRIM28 disfunction in mouse PFC releases TEs and impedes complex social behaviors. The work is an ode to community. Read about it below!
