Guillaume Thibault
Associate Professor www.thibaultlab.com at Nanyang Technological University Singapore 🇸🇬. Endoplasmic Reticulum Stress and Unfolded Protein Response in health and diseases • Co-PI Mechanobiology Institute • MBoC Assoc Editor • University of Toronto alumni
- Help shape the @ascbiology.bsky.social #CellBio2026 program! The official call for session proposals is now open! We are looking for innovative ideas for Minisymposia and Special Interest Subgroup meetings for next year’s meeting. Submit your proposal by February 22 www.ascb.org/cellbio2026-...
- So glad to see this paper out! A small but rewarding contribution from our side. It was a fantastic experience collaborating with @kimingeneva.bsky.social, @ronni.bsky.social, and this great global team on such an interesting manuscript.
- Lactic acid lover? Check out @ronni.bsky.social 's new work in @cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo. www.sciencedirect.com/science/arti...
- Reposted by Guillaume ThibaultEnterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.
- We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297
- We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297
- Most bacteria generate ROS inside their cell but E. faecalis generates ROS outside its cell. Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
- The evidence is in the movement (or lack thereof). 👇 Left: Uninfected cells closing the wound. Middle: Infected cells paralyzed by the bacteria. Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
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View full threadExcited to see our work covered by The Straits Times ! A great summary by Judith Tan 👇 www.straitstimes.com/singapore/he...
- Reposted by Guillaume ThibaultWe’re hiring! @jcellsci.bsky.social is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves #cellbiology and wants to stay connected with the field. A great chance to work for an organisation that believes in helping the community! Details below👇
- Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb. More at: www.biologists.com/about-us/wor...
- Reposted by Guillaume ThibaultIssue 24 is complete Marking the end of @biologists.bsky.social 100-year anniversary celebrations, our cover features members of the JCS community, including some researchers from our ‘First Person’ & ‘Cell Scientists to Watch’ interviews. Explore our ToC: journals.biologists.com/jcs/issue/13...
- Reposted by Guillaume ThibaultWhat's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
- Reposted by Guillaume ThibaultOur Editors will be attending #CellBio2025 @ascbiology.bsky.social @embo.org. Reach out to @seemagrewal.bsky.social and Amelia Glazier to discuss JCS, @focalplane.bsky.social and our other @biologists.bsky.social initiatives.
- Ready for a transformative research journey? 🚀 Join the vibrant, interdisciplinary PhD programmes at NTU College of Science in Singapore! We offer fully funded scholarships. Hear from our students and faculty in the video below 👇 youtu.be/JeZHiXu3fgE
- Our application portal is open until 31 January 2026. Learn more and apply here: www.ntu.edu.sg/science/admi... #NTU #NTUScience #PhD #GradSchool #Scholarships #STEM #Singapore
- Thank you @jcellsci.bsky.social! It was so much fun chatting with Editor @seemagrewal.bsky.social about my journey, research, and advice for junior scientists. It’s great that it reads just like our conversation flowed. I sincerely hope it resonates with trainees out there! Read the interview 👇
- Interview with Guillaume Thibault @gthibault.bsky.social – President of the Society for Cell Biology Singapore We chatted about Guillaume’s route into academia, his research and his advice for junior scientists. journals.biologists.com/jcs/article/...
- Reposted by Guillaume ThibaultInternal documents reviewed by the New York Times reveal Amazon's goal to replace 600,000 jobs with robots. When we support our local businesses, we create a more stable economy—one not at the whim of billionaires. Support your indie bookshop today and every day 💓
- Reposted by Guillaume ThibaultAs part of our commitment to Open Access, we support libraries, consortia and researchers. For #OAWeek, we share a recent webinar that includes tips and recommendations for navigating the editorial process and publishing #OA youtu.be/PjD5QQ-p0Xg #OAWeek25
- Reposted by Guillaume ThibaultSuper interesting! I’m curious what’s considered a “high-fiber” diet for people. Looks like the mice were tested on either no fiber or all carbs replaced with fiber? 🌾VS🍞 #microbiomesky 🧪🦠
- Reposted by Guillaume ThibaultCampus housing 🏡 a big bonus! Plus more than 10 canteens 🥡(we haven't cooked a single meal for a year haha)! My American husband also likes it here :)
- 🚨 JOB ALERT! Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
- Reposted by Guillaume ThibaultEspecially this AI4X postdoc fellowship! ✨🤖 www.ntu.edu.sg/research/res...
- Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs Register 👇 forms.office.com/r/HYfKgmcAa0
- Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs Register 👇 forms.office.com/r/HYfKgmcAa0
- 🚨 JOB ALERT! Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
- What does our start-up package mean in US terms? It's equivalent to $3.8M package at a top US university. Why? We fully cover PI salary costs and 5 PhD scholarships, so your research grant is for research.
- And salary? Due to low taxes & subsidized housing, our offer provides a quality of life comparable to a US$215k - $300k salary in major US academic hubs like NYC or the Bay Area. A great deal for your science and your life.
- Reposted by Guillaume ThibaultExciting news — I am super honored to receive the 2025 MBoC Early Career Paper Award 🎉 My very first award 😊 www.molbiolcell.org/doi/10.1091/... Couldn’t imagine a better send-off as I just wrapped up my postdoc at UNC and get ready to start a lab in Münster this fall 😃
- Reposted by Guillaume ThibaultMIT News: news.mit.edu/2024/human-g... — Sharing our new publication in Cell Genomics: cell.com/cell-genomic... about why our human gut microbiome rarely updates its CRISPR defense systems!
- Pleased to welcome my new colleague from SBS @ NTU Singapore, Anni Zhang @annizlab.bsky.social, to the platform. She is a dynamic addition to our school, and it's always a pleasure to discuss science with her. Looking forward to her contributions here. Find more about her lab 👇
- Hi everyone, I'm a bioinformatician & microbiologist. My new lab @Nanyang Technological University uncovers diverse microbial mechanisms (regulatory networks, selective sweeps, host-microbe interactions, ...) via machine learning! genomiverse.net
- Reposted by Guillaume ThibaultVery honored to receive the Royal Society Research Culture Award - this represents the work of a great team who've worked non-stop since we launched bioRxiv in 2013 royalsociety.org/news/2025/08... www.cshl.edu/inglis-and-s...
- Reposted by Guillaume ThibaultThe endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand. Learn more in a new #SciencePerspective: scim.ag/45GWQrS
- 📣 Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs Register HERE: lnkd.in/gFsquxHe
- 📣 Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up package. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack Register HERE: lnkd.in/gSy5qpA7
- Reposted by Guillaume ThibaultAre you an ambitious, creative researcher keen to investigate neurodegeneration & ageing diseases? Come and join @annebertolotti.bsky.social’s interdisciplinary group, using innovative approaches to tackle protein misfolding in mouse models. www.nature.com/naturecareer... Closes 10 OCT #PostdocJobs
- Reposted by Guillaume ThibaultNature research paper: Quantitative imaging of lipid transport in mammalian cells go.nature.com/4mmSygd
- Reposted by Guillaume ThibaultPrecise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates - @ethz.ch @uzgent.be go.nature.com/41GoBiX
- Reposted by Guillaume ThibaultProteins must be folded into their correct shapes to function properly. @hillerlab.bsky.social discovered tiny “folding factories” in cells that enable efficient and accurate protein folding. @unibas.ch @snsf.ch @natcellbio.nature.com www.biozentrum.unibas.ch/news/detail/...
- Reposted by Guillaume ThibaultOur latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!⚡️Which in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are 🤩!
- 📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!
- The key mechanism? 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴's EET pathway produces a burst of reactive oxygen species (ROS). This, in turn, hyperactivates the unfolded protein response (UPR) in the host's epithelial cells, causing them to stall and even retract from the wound edge. doi.org/10.1101/2025.08.07.669218
- This direct link between bacterial metabolism and host cell stress is a new paradigm for understanding how chronic wounds fail to heal. By targeting this pathway, we might be able to develop new therapies to promote tissue repair. #microbiology #woundhealing
- A huge thank you to the incredible team: @aarontan.bsky.social , @cenkcelik.bsky.social , Stella Yue Ting Lee, Mark Veleba, Caroline S. Manzano, Rahim MK Abdul, and my co-corresponding author @kimingeneva.bsky.social . #teamscience
- Reposted by Guillaume ThibaultDid you know that JCS publishes Tools & Resources articles? These articles describe a new tool, technique or resource that will have a significant impact on #cellbiology research. Tell people about your latest tool/resource and send your article our way! journals.biologists.com/jcs/pages/re...
- Very happy to see how this project turned out. It was an awesome collaboration with Marek Mutwil and I learned so much along the way.
- PlantConnectome: A knowledge graph database encompassing >71,000 plant articles (Shan Chun Lim , Manoj Itharajula , Mads Harder Møller , Rohan Shawn Sunil , Kevin Fo , et al) doi.org/10.1093/plce... #PlantScience
- Reposted by Guillaume ThibaultHard at work here in Singapore with @gthibault.bsky.social
- Reposted by Guillaume ThibaultWe have some news! We find that the post-synaptic Homer proteins coordinate YAP and Wnt signaling in epithelial cells, downstream of the Crumbs polarity complex. They do so by sequestering YAP and beta-catenin in biomolecular condensates, and by suppressing a FRYL/NDR complex. Check it out!
- Reposted by Guillaume ThibaultAre you a PI in a biology field looking for students to join your lab as a PhD student? I made a Starter Pack to help PIs and potential PhD students connect! If you would like to be added to this pack, please let me know! go.bsky.app/EFj87fiat://did:plc:hsnbex4tim4ajhv3dmgr4x5a/app.bsky.graph.starterpack/3lu4sd3bklb24
- Reposted by Guillaume Thibaultgo.bsky.app/8zZNEGV Great resource to connect early career folks with more senior scientists looking to hire postdocs! 🧪at://did:plc:hsnbex4tim4ajhv3dmgr4x5a/app.bsky.graph.starterpack/3lu4ibqptju2g
- Reposted by Guillaume ThibaultExcited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way! #notforprofit
- Reposted by Guillaume ThibaultResearchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels go.nature.com/4nNF3ri
- Reposted by Guillaume ThibaultThe "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field? That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience A 🧵 1/n
- Reposted by Guillaume Thibault🧵1/ New preprint out! We reveal that ERAD, a protein degradation pathway, selectively targets intracellular PILS auxin transport facilitators to control growth. This expands ERAD's role beyond protein quality control, right into developmental regulation. www.biorxiv.org/content/10.1...
- 🌿 Check out Jan Hübbers’s In Brief article on our PlantConnectome, just accepted at The Plant Cell! @theplantcell.bsky.social 📄 t.co/qHrRaq0Sx9 Thrilled to have teamed up again with Marek Mutwil on this and other Connectome projects! Explore the PlantConnectome 👇 plant.connectome.tools
- Reposted by Guillaume ThibaultKnown in-house as ‘the owl issue’ 😁 🦉
- Congratulations @vjrubenstein.bsky.social
- Microtubules do more than move chromosomes—they help clean up cellular messes too. 🧹 Eric Rubenstein of Ball State University shows Kar3 and Vik1 are key to protein quality control via ER-associated degradation. 📖 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology #ERAD #Proteostasis
- Reposted by Guillaume ThibaultJoin a global community of cell biologists! ASCB offers memberships for every career stage — students, postdocs, educators and industry pros. Access resources, events and expert networks. 👉 www.ascb.org/membership/ #ASCB #CellBiology #ScienceCommunity #CareerGrowth
- Reposted by Guillaume ThibaultHuge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social
- Reposted by Guillaume ThibaultJun #SGBUG with Aaron Tan from the groups of @kimingeneva.bsky.social and @gthibault.bsky.social talking about exciting findings on E. faecalis pathogenesis, and @weeboont.bsky.social from our lab sharing his newest work on phospholipid transporters in E. coli! @scelse.bsky.social Awesome crowd!
- Reposted by Guillaume Thibault"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
- Reposted by Guillaume ThibaultOur ‘Cell Scientist to Watch’ is Francesca Bottanelli @franbottanelli.bsky.social. We discover more about Fran’s career path, her approach to scientific mentorship and her dream to start a band! journals.biologists.com/jcs/article/...
- Reposted by Guillaume ThibaultOur Journal Meetings return in 2026. Find out more and sign up for registration and abstract updates: biologists.com/meetings/ #Biology #Research #AcademicJournal #Academia #Communication #Science #Collaboration
- Reposted by Guillaume ThibaultNew capabilities! SCELSE has installed a new isothermal microcalorimetry system (Symcel CalScreener) to track microbial metabolism in real-time — including responses to antibiotics, phage; and in biofilms and during transitions to alternate lifestyles. Pix (R): Prof Whitchurch - cwhitch.bsky.social
- Reposted by Guillaume ThibaultThe copyright statement of Elsevier now includes AI training.
- Reposted by Guillaume ThibaultStepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 www.nature.com/articles/s41...
- Reposted by Guillaume ThibaultNon-profit journals are on the critical list. The cause: academics obsession with the Nature brand, coupled with the APC $ model. Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
- Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is: “…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
- Reposted by Guillaume ThibaultI hope you are attending Worm2025 in June. Please consider submitting to our awesome Worm Art Show. It is as good as the science. Submissions accepted till June 27, 2025. Started by Ahna Skop @ahnaskop.bsky.social the event continues to enrich our community. genetics-gsa.org/worm-2025/wo...
- Reposted by Guillaume ThibaultA large-scale genomic study in Science of over 1500 individuals from 139 underrepresented Indigenous groups across northern Eurasia and the Americas sheds new light on the ancient migrations that shaped the genetic landscape of North and South America. Learn more: scim.ag/4mi1yUf
- Reposted by Guillaume ThibaultThere appears to be a new wave of scientists and medics joining @bsky.app, so am resharing these starter packs. Let me know if you’d like to be added. ISR & UPR cell biology go.bsky.app/8VzRKLW NHS respiratory go.bsky.app/B9XSgP1 Mesothelioma research go.bsky.app/EvS1KrKat://did:plc:iabqmvcjaa4fkabcfquwltjt/app.bsky.graph.starterpack/3lboon5s7jg27
- Reposted by Guillaume ThibaultMore than 100 higher education institutions and funders have publicly endorsed eLife, stating the journal is still considered in hiring, promotion and funding decisions despite losing its impact factor #AcademicSky #EduSky
- Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇 www.ntu.edu.sg/science/rese...
- Reposted by Guillaume ThibaultTMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5
- Reposted by Guillaume ThibaultDid you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...
- Reposted by Guillaume Thibault🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast! Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social #FASEB2025 #ERSRC
- 🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking. Check out the program and register here 👇 events.faseb.org/event/endoplasmic-reticulum-function-disease
