Peggy Goodell
The Goodell Lab. Hematopoietic stem cells, epigenetics, DNA methylation. Houston Texas. Posts are my own.
- Today's the print release of a #RibackLab and #GoodellLab collaboration— we’re excited to share the visual story behind the science, including the dramatic artwork that inspired how we thought about aberrant function of NPM1c - which occurs in about 1 in 3 adult acute myeloid leukemias (#AML).
- NPM1c comes from a tiny frameshift that creates a nuclear export signal in what is normally a nucleolar protein. In earlier work, we portrayed its HOX-activating force as a mischievous gremlin straining to escape the nucleus—an image that captured how disruptive this mutant is.
- Reposted by Peggy Goodell[Not loaded yet]
- Reposted by Peggy Goodell[Not loaded yet]
- Reposted by Peggy GoodellNew paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...
- Reposted by Peggy GoodellExcited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.
