Georg Keller
Neuroscientist studying the mechanisms of psychiatric treatments.
apredictiveprocessinglab.org
- We think cortex might function like a JEPA. It looks like prediction errors in layer 2/3 are not computed against input (as is the idea in predictive processing), but against a representation in latent space (i.e. like in a JEPA arxiv.org/abs/2301.08243 or RPL doi.org/10.1101/2025...).
- Our work with @georgkeller.bsky.social on testing predictive processing (PP) models in cortex is out on biorvix now! www.biorxiv.org/content/10.6... A short thread on our findings and thoughts on where we should move on from PP below.
- We suspect, a model that combines the self-supervised learning of JEPA (@yann-lecun.bsky.social and team), the credit assignment and capacity to work on arbitrary graphs of predictive processing (work of the lab of Rafal Bogacz),
- Reposted by Georg KellerJoin leading scientists for a 3.5-day #LakeConference discussion on: "The Neurobiology of Mental Health" at the level of genes, cell types, organoids, circuits, networks and brain systems. Learn more & apply by January 31: lakeconferences.org/conf/1ed63fdb-de0c-…
- Reposted by Georg KellerJoin us this May to explore the biological mechanisms of mental health challenges and treatment strategies. Apply by January 31: lakeconferences.org
- Reposted by Georg Keller1/6 New preprint 🚀 How does the cortex learn to represent things and how they move without reconstructing sensory stimuli? We developed a circuit-centric recurrent predictive learning (RPL) model based on JEPAs. 🔗 doi.org/10.1101/2025... Led by @atenagm.bsky.social @mshalvagal.bsky.social
- One of the most promising approaches to making headway in understanding the cortical algorithm that I have seen in a long time! www.biorxiv.org/content/10.1...
- Reposted by Georg KellerIn this first-person account, FMI’s senior communications manager describes taking part in an early human trial that adapts previous experiments in mice to explore how the human brain responds when visual and auditory information suddenly fall out of sync. www.fmi.ch/news-events/...
- Reposted by Georg KellerApplications are open for the #LakeConference on the Neurobiology of Mental Health in Lake Thun, Switzerland. 📆 May 17-21, 2026 🏔️ All career stages welcome ⏳ Apply by January 31, 2026 Learn more and apply: t.co/WcuXHdWnFa @lakeconferences.bsky.social
- Reposted by Georg KellerVery much looking forward to this collaboration with @georgkeller.bsky.social at @fmiscience.bsky.social, using a cross-species approach in humans and mice to investigate the effects of antipsychotics on cortical circuit function.
- FMI’s Prof. @georgkeller.bsky.social and UPK Basel’s Prof. Philip Sterzer have been awarded a 1.5 M CHF @snf-fns.ch grant to study how brain circuit changes underlie schizophrenia — bridging fundamental neuroscience and clinical research from mice to humans 🧠 www.fmi.ch/news-events/...
- Reposted by Georg KellerJoin us for the second Neurobiology of Mental Health conference (May 2026) that will explore the biological mechanisms underlying mental health challenges and their treatment. Information and application on: lakeconferences.org. The deadline for applications is January 31st, 2026.
- Reposted by Georg KellerPlease share: Postdoc position available in a new collaborative SNSF project with @georgkeller.bsky.social at @fmiscience.bsky.social using a cross-species approach in humans and mice to investigate the cortical circuit mechanisms underlying schizophrenia. Apply at karriere.upk.ch/Postdoctoral...
- Reposted by Georg KellerI’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time! www.biorxiv.org/content/10.1...
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- Reposted by Georg Keller🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
- I often get asked “do you think visuomotor mismatch responses are a mouse thing?” – it looks like at least humans have them as well. very excited by this!
- Reposted by Georg KellerDitching months-long delays for fast, constructive feedback. This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.
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- Reposted by Georg KellerIn his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments. #neuroskyence www.thetransmitter.org/systems-neur...
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- Consistent with the work of @jeremiahycohen.bsky.social and @mishaahrens.bsky.social labs, we find that serotonin axons in mouse visual cortex appear to signal recent visuomotor uncertainty (and unlike norepinephrine axons, they have no visuomotor mismatch responses) www.biorxiv.org/content/10.1...
- Just in case you - as we did - were wondering whether humans would have any of these pesky visuomotor mismatch responses certain people have seen in mice...
- The answer is yes - awesome experiments by @solygamagda.bsky.social
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- In @elife.bsky.social: Multimodal mismatch responses in mouse auditory cortex doi.org/10.7554/eLif...
