- Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells @unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
- We constructed reporter poxviruses to track inflammasome assembly in human primary cells ....
- ... identified #nanobodies that block AIM2 inflammasomes by interfering with AIM2 Pyrin filament oligomerization (sequences deposited in nanosaurus.org data base) ...
- ... and engineered reporter poxviruses to impair AIM2 inflammasomes in human primary cells with inhbitory nanobodies, revealing that primary macrophages and keratinocytes assemble #AIM2 inflammasomes, while monocytes assemble #NLRP3 inflammasomes.Jan 21, 2026 01:59
- The reporter is described here: www.biorxiv.org/content/10.1...
