New preprint! A bold aspiration, to target and control genes as chromatin complexes, not as nucleotide strings. How it started: total noise. New resolution: fuzzy blobs coming into focus. Not perfect yet but a huge step.
khayneslab.wordpress.com/2025/11/27/r...
Research – bioRxiv – Decoding Gene Responsiveness to Synthetic Chromatin Reader-Actuators with Multi-Modal Epigenomic Profiling
Decoding Gene Responsiveness to Synthetic Chromatin Reader-Actuators with Multi-Modal Epigenomic ProfilingKim SH, Enwerem-Lackland I, Williams NL, Fisher R, Plaisier CL, Haynes KA. (2024) bioRxiv.D…