Gabriel Aughey
Neurobiologist at UCL. Interested in neurological disease, genetics, behaviour, and development.
- Started my fellowship in January - just gearing up to submit my first independent grant and everything has been cancelled! This letter provides no reassurance for ECRs in my position. And why was there no consulation or warning that this was going to happen!? www.ukri.org/news/open-le...
- Does anyone have a protocol for homebrew HCR in situ probes? I've seen several published protocols for designing inititators to use with molecular instruments amplifiers - but it looks like they wont share their sequences anymore!?
- Always shocking to see these kinds of data collected together. "[publishers made]US$12 billion in profits between 2019 and 2024" - That's $12 billion diverted away from actual research or materially supporting the community - these are disgusting numbers.
- Really confused about what problem LLMs like qed are meant to be solving? Is it meant to be for people writing papers - in which case we already have well established mechanisms for feedback (i.e. speaking with human colleagues), or for reviewers - obviously problematic for so many reasons!?
- Reposted by Gabriel AugheyPREACH! www.nature.com/articles/s41...
- Reposted by Gabriel AugheyWe currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
- URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
- Reposted by Gabriel AugheySUSTAINABILITY & #DROSOPHILA - If you keep flies & have tried to re-use containers but then given up on it, please could you let us know & tell us the reasons? We urgently need statements for a publication about sustainability in fly labs. Please, contact Andreas.Prokop@manchester.ac.uk
- Reposted by Gabriel AugheyURGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
- My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate. www.philanthropy.cam.ac.uk/give-to-camb...
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- Reposted by Gabriel Aughey1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
- Reposted by Gabriel AugheyWhy academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...
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- I've been a bit slow to post about this, but our work on RBL2-linked disease is now available online in #Brain. We provide a comprehensive characterisation of clinical phenotypes, and explore the neurological function of the #Drosophila orthologue, Rbf. (1/2) doi.org/10.1093/brai...
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- Was wondering what had been going on. Please stop this - flybase is my emotional support database - I need to visit several times just to get through the day!
- Reposted by Gabriel AugheyIf anyone happens to need it this week for...reasons...this is the best graphic on the complexity of human sex determination I've ever seen. I use it in an undergrad course on gene regulatory mechanisms. Shoutout to @unamandita.bsky.social! www.scientificamerican.com/article/beyo...
- Reposted by Gabriel AugheyThe birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging. www.nature.com/articles/nbt...
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- Reposted by Gabriel AugheyOur new preprint is out - please share! We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals. Grab a ☕ and let’s dive in. 🧵🧪 1/n #CRISPR #geneediting
- Reposted by Gabriel AugheyWould you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
- Reposted by Gabriel AugheyThrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵
- A (lightly) paraphrased sample of recent feedback from a failed fellowship application: Strength - The project was important and ambitious. Weakness - While the project was interesting and important, it was too ambitious to fund. ...not really sure what to take from this experience!🤔
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