Kejia Li
Postdoc in Savitski lab, EMBL, Heidelberg. Interested in functional proteomics, microbiology, metabolism, and drug target discovery.
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- Reposted by Kejia LiIn this month's Editorial, we highlight some of the Nature Methods editorial team members' favorite papers we published in 2025! www.nature.com/articles/s41...
- After working on proteomics for eight years, first time to present a poster but at an AI symposium😅 Happy to know, always happy to learn #AI in drug discovery & development
- A Very comprehensive study! Some previous studies have used drug-induced changes in target abundance to identify targets; although it’s not always the case.
- Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...
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- Joined a conference talk a week ago in EMBL, which introduced how mammal cells detoxify m6A and how the accumulation influences metabolism. Was wondering how about bacteria. What’s the function of m6A or m6dA in Ecoli. Very in-time preprint 👋
- Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides tinyurl.com/ch3damp We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity Revealed by the amazing Ilya Osterman. See his thread below👇
- Finally out! 🤩 Check out our HT- PELSA for high throughput screening！
- Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️
- Reposted by Kejia LiHT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊 🔗 www.embl.org/news/science...
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- Cool!
- Congrats!
- New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...
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- Wow!
- Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
- Reposted by Kejia Li‘Solar-powered’ sea slugs have specialized depots in their cells that store photosynthetic equipment looted from algae go.nature.com/4l27lMN
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- Not directly relevant to the paper: pick up your chemistry as it will definitely help you to better understand many cellular biological processes.
- Good to know which metrics should be evaluated from a quantitative perspective
- Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists www.biorxiv.org/cont... --- #proteomics #prot-preprint
- Good to learn how metabolites influence the protein complex formation and the multifaceted functions of metabolites in different processes!
- Reposted by Kejia LiNew work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...
- Reposted by Kejia Li🚨Our new paper is online🚨 We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics www.cell.com/cell/fulltex...
- Reposted by Kejia LiWant to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...
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