Andrii Bugai
Scientist at Aarhus University (DK).
Alumni of the University of Helsinki (FI) and Kharkiv University (UA).
I study how genes are regulated at the level of RNA.
- Triangle Galaxy
- Clear winter atmosphere, busy orbit.
- Reposted by Andrii BugaiIntrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.
- RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing biorxiv.org/content/10.64898/20…
- Full moon of 2026
- RP
- Onions Nebula finally back
- Reposted by Andrii BugaiThrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!
- Choose your cluster...
- October's colours of the Moon
- Check the highlights of our recent nuclear RNA sorting story here:
- How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
- Images from summer. Part 3.
- This one is prettier than Andromeda.
- Images of summer. Part 1.
- Reposted by Andrii BugaiLove RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
- PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...
- Check out our latest preprint, focusing on how nuclear decay and export compete for poly(A)+ RNAs utilizing the same biochemical mechanism.
- First #Moon shot of June
- Limited sleep on starry nights...
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- Different flavours of #eclipse
- Nebulae, Orion constellation
- Tiny Circle Nebula
- First attempts with new toys...
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- First auroras of the year!
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- At the right side of winter
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- Ghost
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- Great methodological preprint about performing #CRISPR knock-in. Basically, everything you need in one place.
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- Violent weather in #Aarhus today.
- The ultimate goal is to leave that another network, which still gets some of my screen time. Hope #BlueSky makes it. #HiSciSky #EduSky #AcademicSky
- I wish there will be more focused reviews like the one below: Noncoding snoRNA host genes are a distinct subclass of long noncoding RNAs And yes, I might keep here in #BlueSky my extremely nerdy #SciReadingClub #RNA #gene_regulation #EduSky www.cell.com/trends/genet...
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