- Cytoarchitecture matters. Brodmann was right. I made a quick post about it: labrigger.com/blog/2026/01... and here's a quick summary thread of the quick post. (1/4)
- 𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...
- The best neuroanatomists reveal order in the brain, where it previously looked like spaghetti wiring. They use cytoarchitecture to do this. Like this amazing work from Andreas Burkhalter. If you want to question the relevance of cytoarchitecture, you better be as precise as they are. (2/4)
- It's not precise enough to use a rigid atlas or skull landmarks. When you get functional landmarks in individual animals like Andreas et al. do, the boundaries are sharp. 2p calcium imaging data, pooled across animals AFTER precision mapping in individuals. elifesciences.org/reviewed-pre... (3/4)
- The paper claims that it challenges "the traditional emphasis on cytoarchitecture, instead pointing to intrinsic connectivity” False dichotomy. Of course connectivity matters. The paper (which has value in other parts) doesn't provide evidence for the irrelevance of cytoarchitecture. (4/4)
