Ming Lee
Cat dad. Sexual Health and HIV doctor. He/Him 🏳️🌈
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- Delighted to be able to present my PhD findings of bNAb in gut tissue, alongside the primary RIO trial findings at the Keystone HIV cure symposium in Durban! #KeystoneSymposium #HIVcure2025
- At the Keystone HIV cure symposium in Durban, South Africa. Looking forward to a great line up of talks and the chance to meet other cure researchers around the globe! Prof Ndung'u opens the meeting with a keynote talk on combination HIV cure approaches in resource limited settings.
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- 4mthly IV/SC N6LS with mthly CAB maintained viral suppression, but there were a small but significant group of people who experienced viral control failure. Like many other bNAb studies, these findings suggest we may have a while to go for the use of bNAbs as a direct antiviral. #CROI2025
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- Tecovirimat did not lead to faster clinical resolution, or reduction of pain, for clade 2 MPOX. We need new agents to treat MPOX. #CROI2025
- Ensitrelvir, a SARS-CoV-2 C3 like protease inhibitor reduced incidence of COVID-19 by two-thirds up to day 10 after exposure. #CROI2025
- Frailty was associated with an increased risk of MACE in the REPRIEVE study. However frailty did not seem to impact the effectiveness of pitavastatin on preventing MACE outcomes. Caveat limited sample size and events in this relatively young cohort assessed with low-mod CVD risk. #CROI2025
- Findings from the last gift cohort. Although total HIV DNA measures were similar in the spinal cord (SC) compared to the brain, there was higher HIV diversity seen in the SC. SC may be an important site of HIV dispersal. #CROI2025
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- Roger Paredes on Long COVID. Lots of evidence now that viral persistence seen up to 2yrs after initial infection is seen in people with long COVID. LC is associated with increased thromboinflammation. The way forward - greater pt involvement, adaptive RCTs, and vaccination! #CROI2025
- It's great to see two more people reported to be in remission from HIV after stem cell transplants at #CROI2025. But stem cell transplants remain a high risk procedure and not feasible for all, and we need safer, more scalable and accessible cure interventions for people living with HIV.
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- Really exciting data on once yearly Lenacapravir. Safe and well tolerated with little injection site reactions, pain reduced with with pre treatment ice. Trough levels higher than twice yearly formulations. Potentially helpful for pairing with other long acting rx eg. bNAbs in the future?
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- At the Stand up for science protest yesterday. There was anger, there was determination. As researchers, clinicians, and activists, we stand together as a community. And the crowd chanted: ACT UP, FIGHT BACK. #CROI2025
- Prof Sarah Fidler presents the long-awaited results of #RIOstudy of dual bNAbs vs placebo in people with early HIV. Pts receiving bNAbs were 91% more likely to experience viral suppression up to 20 weeks compared to placebo, and more than a third remained suppressed after two doses beyond 72 wks.
- A beautiful closing performance for the #CROI2025 opening session by the SF Gay Men's choir.
- Prof Adeeba Kamarulzaman shares how she sought allies, including a religious scholar, to successfully implement opoid replacement harm reduction programmes in Malaysia. However science isn't enough, and she shares the challenges and progress in changing drug policies and laws. #CROI2025
- A powerful talk by Rebecca Denison, founder of WORLD and woman living with HIV. We can't go back to the days without treatment access. Silence is death. And courage is a decision. The hall erupted in a standing ovation. #CROI2025
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- CROI chair Prof Havlir reaffirm the commitment of CROI to support scientific gatherings with free exchange of ideas, and condemns the censoring of science. She also highlights the response to US federal policy changes. #CROI2025
- Exciting talk on liver steatosis by Dr Khalili - a number of promising treatments for liver steatosis, including GLP1 agonists (yet another thing GLP1 is good for!) #CROI2025
- Dr Joseph Eron gives an excellent overview of cure research highlights at #CROI2025. Why a cure is still needed, and likely strategies including bNAbs cure strategies.
- Really powerful to hear video testimonies from people living with HIV to introduce each section in the new investigators workshop at #CROI2025. Particularly as the follow up questions highlight how the recent funding restrictions have affected HIV research, care delivery, and medication access.
- blogs.imperial.ac.uk/imperial-med... I can't not talk about the work we're doing in new HIV treatments and cure on #WorldAIDSDay. My supervisor, Professor Sarah Fidler, and Jonas Bergmann, from Amsterdam, share their thoughts on the evolution of HIV treatments and cure, and ongoing challenges.
- blogs.imperial.ac.uk/imperial-med... It's #WorldAIDSDay 2024. Professor Alan Winston, @imperialcollegeldn.bsky.social, shares how language contributes to stigma, and how we can reduce discrimination and empower people with person-centred language in medicine and research.
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- New to Bluesky? Check out the one-click starter packs by @positivelad.bsky.social to follow sexual health and HIV bluers!
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- If altmetric is here, the journals are hopefully soon to follow.
- Really helpful tips for those new to Bluesky like me!
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- Meet Sesame and Olive I also post cat pictures (for more reasons to follow me). #ragdoll #britishshorthair
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