did:plc:wwjkeu7psto3syi6ksimysoi
Neuroscience lab. We study decision making, exploration and addiction. We are interested in inter-individual variability.
- Congratulations Lauren
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi⚠️ New paper alert and what a way to end 2025! 🎉 Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience. Sleeping dragons 🦎 and functional ultrasound! Read the full paper here: rdcu.be/eWJHb 1/8
- Congrats, well deserve
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoiYou just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here: emploi.cnrs.fr/Offres/CDD/U...
- Big news for @laurenmac.bsky.social ! 2025 is quite a year: CNRS position + ERC Starting Grant Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood. @cnrs.fr @espciparispsl.bsky.social www.insb.cnrs.fr/fr/personne/...
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi[Not loaded yet]
- Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states. www.nature.com/articles/s41...
- A circuit-level explanation for nicotine’s dual impact: Nicotine activates VTA→NAc dopamine neurons (reward), but this comes at a cost: It triggers a GABAergic feedback loop that inhibits VTA→amygdala neurons (emotion). One drug, the dopaminergic circuits, 2 effects: reinforcement + negative affect.
- Our work on the role of the interpeduncular nucleus in nicotine reward ( www.cell.com/neuron/abstr... ) is featured in a Neuron Preview ! Brandon J Henderson highlights how a new regulatory circuit controlling nicotine reinforcement has been uncovered. www.cell.com/neuron/abstr...
- Yesss! So happy to see this, totally deserved!
- Thrilled to share that I have obtained a permanent position at CNRS 🎉🎉🎉 Thanks so much to everyone that supported me along the way, and especially @faurelab.bsky.social !
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi[Not loaded yet]
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoiNouvel article avec mes ami-es belges E. Chaves et A. de Kerchove où on décrit l'effet de l'activation de populations de neurones du striatum sur les stratégies de décision. On a essayé de sortir d'une définition "par l'expérimentateur" de la performance des souris. www.science.org/doi/10.1126/...
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoiHot off the press: The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience: rdcu.be/ek010
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoiI have an opening in my lab for a postdoctoral fellow to work on projects that relate to the mechanisms of neurotransmitter release by dopamine neurons and/or on how inflammatory signals infuence the functionning of these neurons. Please share.
- The interpeduncular nucleus (IPN) dampens nicotine reward via β4* nAChRs and IPN→LDTg projections. Blocking this pathway enhances VTA responses and CPP: A nicotine-specific brake embedded in the mesolimbic system. New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi[This post could not be retrieved]
- New preprint from the lab and @clementsolie.bsky.social on social organization & neuromodulation! Read the full preprint here: www.biorxiv.org/content/10.1... @espciparispsl.bsky.social @cnrsbiologie.bsky.social
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi[Not loaded yet]
- Superb study from Thomas Preat's team here @espciparispsl.bsky.social @cnrsbiologie.bsky.social , showing that astrocytes use redox H₂O₂ signaling to support memory in Drosophila. Amyloid-β disrupts this process, linking it to cognitive deficits in Alzheimer’s. www.nature.com/articles/s42...
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi#RésultatScientifique🔎Comment la dopamine peut-elle orchestrer à la fois l’apprentissage et la motivation ? @jeremie-n.bsky.social propose une réponse à cette question dans @naturecomms.bsky.social ⤵️ 🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi[Not loaded yet]
- "Dopamine builds and reveals reward-associated latent behavioral attractors". This study combines computational modeling and experimental work to reveal how DA not only teaches, but also motivates, i.e by creating and using pathways toward goals. www.nature.com/articles/s41...
- Reposted by did:plc:wwjkeu7psto3syi6ksimysoi[Not loaded yet]
