Stoyo
Neuroscientist at the Gogolla lab, Max Planck Institute of Psychiatry. Trying to understand emotions. Doing optical things in the insula.
- Reposted by StoyoOur work with @georgkeller.bsky.social on testing predictive processing (PP) models in cortex is out on biorvix now! www.biorxiv.org/content/10.6... A short thread on our findings and thoughts on where we should move on from PP below.
- Reposted by StoyoExplicit and implicit modularity that emerges in simple neural network models even in the absence of anatomical constraints. Whether modularity emerges or not strongly depends on the geometry of the inputs and other factors. Extensively revised article with many new results. With @wjj.bsky.social
- When and why do modular representations emerge in neural networks? @stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)
- Reposted by StoyoFacial expressions may involve an “everything, everywhere, all at once” type of coding in the brain, a new study suggests. By @natmesanash.bsky.social #neuroskyence www.thetransmitter.org/emotion-proc...
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- Recently published: The Study of Emotion in Other Animals - a primer on affective neuroscience in “nonhumans”. Framework and case studies for probing emotions in the brain. Cambridge Handbook of Human Affective Neuroscience. Thanks to @gogolla.bsky.social! www.cambridge.org/core/books/a...
- Reposted by Stoyo"My New Year's Resolution is to find a principled way to think about all those cell types in the brain" Why friend, you are in luck, because @rgast.bsky.social has just the perspective for you: www.sciencedirect.com/science/arti...
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- Reposted by StoyoNew Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵 rdcu.be/eVZ1A
- Reposted by Stoyolab preprint! Interopceptive predictions are central to many brain-body interactions theories, but it's unclear if/how they affect bodily physiology. We (fearless Einav Litvak et al) show that insular cortex predictions are essential for glucose homeostasis-THREAD.. www.biorxiv.org/content/10.6...
- Reposted by StoyoNew review out! 🔥🧊 We break down how rodents, primates & insects encode temperature in Nature Reviews Neuroscience. Paper: www.nature.com/articles/s41... View-only: rdcu.be/eThU1
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✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡 www.biorxiv.org/content/10.1... 1/13 🧵 - Reposted by Stoyo[Not loaded yet]
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- Reposted by StoyoExciting new work from former team members Eric Romero, Cwyn Solvi, Fei Peng and colleagues makes the cover of Science: affective contagion in bumblebees! www.science.org/doi/10.1126/...
- Reposted by StoyoCorrection for multiple comparisons should be ubiquitous www.nature.com/articles/s41... 👍👏
- Reposted by StoyoReally interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine: www.nature.com/articles/s41... I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
- Reposted by StoyoCome be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far!
- During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756
- Reposted by StoyoAll-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: www.biorxiv.org/content/10.1...
- Reposted by StoyoFinally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain. A brief rundown... www.nature.com/articles/s41...
- Reposted by StoyoCharacteristic facial features in mice simultaneously encode not only currently used decision variables but also independent and unexpressed ones, and these features partially originate from neural activity in the secondary motor cortex @fannycazettes.bsky.social www.nature.com/articles/s41...
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- Reposted by StoyoAnd we are live! Excited to announce the 2025 Multi-Agent Behavior Challenge on cross-lab supervised action recognition in mice 🐁🐀🖱️ Running on Kaggle until December 15th, with a $50,000 prize pool going to the top five submissions! www.kaggle.com/competitions...
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- Reposted by StoyoThrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
- Reposted by StoyoExcited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
- Reposted by StoyoWe're going to see a lot of bullshit in the coming days and weeks about "causes of autism", and most will be based on flawed, over-interpreted observational studies (1/n)
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- Reposted by StoyoNew Open dataset alert: 🧠 Introducing "Spacetop" – a massive multimodal fMRI dataset that bridges naturalistic and experimental neuroscience! N = 101 x 6 hours each = 606 functional iso-hours combining movies, pain, faces, theory-of-mind and other cognitive tasks! 🧵below
- Reposted by StoyoMy new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight. These disputes are multidimensional, principled and fascinating. Here, I unpack them. www.thetransmitter.org/the-big-pict...
- Reposted by StoyoFinding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection. When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.
- Sad day for peope who still believe brain areas are the primary organizational units of function in the brain. www.nature.com/articles/s41...
- Reposted by StoyoExcited to share our new preprint on the brain-wide organization of intrinsic timescales at single neuron resolution. Work w/ @roxana-zeraati.bsky.social, @intlbrainlab.bsky.social, Anna Levina, @engeltatiana.bsky.social : www.biorxiv.org/content/10.1...
- Reposted by StoyoNew preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12
- Reposted by StoyoI still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...
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- Reposted by StoyoProposal recommended for funding! Which means we have a fresh, 3-year-funded position available for a computational postdoc interested in studying dynamics of social interactions in rats, with simultaneous Neuropixels data to follow 🐀🐀🐀 Proper job ad pending, but email me if interested!
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- Reposted by Stoyo📅 Next week, we are excited to welcome Dr. @yoavlivneh.bsky.social from Weizmann Institute of Science. He will share his research on the #insular #cortex. 🥳 As always, everyone is welcome to join us at our Institute, and registration is not necessary! All info here: www.psych.mpg.de/events/40140...
- Reposted by StoyoThe firing of neural populations is high-dim even if their subthreshold activity is low-dim! This work by @bio-emergent.bsky.social and @haydari.bsky.social shows how, with a solvable model, a data analysis technique, and data from mouse visual cortex: www.biorxiv.org/content/10.1...
- Reposted by StoyoIs it finally time for systems neuroscience to take hormones seriously? OMG YES! @meenakshiasokan.bsky.social and I share some of our thoughts about recent work in this review www.sciencedirect.com/science/arti...
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- Reposted by StoyoCongratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...
- The HNC (Human Neural Circuitry) team at our launch celebration at Stanford! Story here: med.stanford.edu/news/all-new...
- We got to write a short perspective piece for a very impressive paper published today in @science.org "Conserved brain-wide emergence of emotional response from sensory experience in humans and mice". Congrats to the team! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
- Reposted by Stoyo🧠What do random neural networks have in common with the motor cortex? Turns out, a lot! Both exhibit similar low‑dimensional dynamics across sensorimotor tasks.👇🧵
- Reposted by StoyoI’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8) rdcu.be/el19t
- Reposted by Stoyo🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n
- Reposted by StoyoMy lab has several postdoctoral fellow and software engineering positions available. Please email me if you’re interested.
- Reposted by StoyoDoes your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/
- Reposted by StoyoContrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...
- This is great! Would love to see similarly structured and rigorous quality controls for calcium imagining data
- Reposted by StoyoKilosort4 detects a LOT of neurons, I recorded 15k neurons in one year 🤯 Traditionally, one would curate these detected units to see if they are well isolated single neurons. This is not feasible anymore, so today let's look at three options that are out there to automate this process! 🤖👇
