Meghan Morrissey
Interested in how macrophages count and measure, and macrophage-cancer interactions. Assistant prof at UCSB morrisseylab.mcdb.ucsb.edu
- Reposted by Meghan MorrisseyCongratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
- Reposted by Meghan Morrissey[Not loaded yet]
- We have TWO papers out in @jcb.org this month! 🎉 First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social doi.org/10.1083/jcb....
- Second, Wyatt Miller clarifies the downstream signaling pathway that the "Don't Eat Me" signal CD47 uses to stop phagocytosis. A very satisfying answer to a major question we've had since I started my postdoc, with lots of interesting implications doi.org/10.1083/jcb....
- Reposted by Meghan Morrissey[Not loaded yet]
- Reposted by Meghan Morrissey[Not loaded yet]
- Could not agree more 😁
- Reposted by Meghan Morrissey@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...
- Reposted by Meghan Morrissey#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...
- Reposted by Meghan Morrissey[Not loaded yet]
- Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...
- Excited to share @kirstin-rollins.bsky.social thesis project! 🥳Why do macrophages sometimes eat a whole cell, and sometimes just nibble off pieces? We found that if the target cell is stuck to a substrate or part of a 3D tissue, the macrophage nibbles instead of phagocytosing the whole cell.
- Reposted by Meghan MorrisseyTrump & Musk are making massive cuts to the National Institutes of Health. I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
- Extremely grateful to Damon Runyon for this funding, especially with todays news on NIH grants. See a green macrophage nibbling on a pink cancer cell 👇
- @mmorrissey.bsky.social is investigating how immune cells known as macrophages might be induced to “nibble” cancer cells to death through a process called trogocytosis.
- Reposted by Meghan Morrissey@mmorrissey.bsky.social is investigating how immune cells known as macrophages might be induced to “nibble” cancer cells to death through a process called trogocytosis.
- Reposted by Meghan MorrisseyCongratulations to the recipients of the 2025 Damon Runyon-Rachleff Innovation Award! Five exceptional scientists received initial grants, and three previous awardees were given Stage 2 support to continue their critical work. Read more: www.damonrunyon.org/news/entries...
- Reposted by Meghan Morrissey[Not loaded yet]
- Reposted by Meghan Morrissey[Not loaded yet]
- Macrophages need to adjust their appetite based on whats happening around them... but how to make a macrophage hungrier? Annalise Bond assembled a list of biophysical and biochemical parameters that can tune phagocytosis. @jcellsci.bsky.social @biologists.bsky.social doi.org/10.1242/jcs....
- At #Ascb? Check our Wyatt Millers poster on CD47 today at 1:30 (b696) or his talk Monday at 5:30 p in the immune cell biology subgroup!
- Reposted by Meghan Morrissey[Not loaded yet]
- Reposted by Meghan Morrissey[Not loaded yet]
- Such a great study showing that target biophysics govern the decision to trogocytose (nibble) vs phagocytose
- Do you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior. www.biorxiv.org/content/10.1...
- Reposted by Meghan MorrisseyDo you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior. www.biorxiv.org/content/10.1...
