Adrien Leger
Director of Modified Bases Research at @nanoporetech.com
EMBL-EBI alumni, keen cyclist and father of two.
Views are my own. Reposts are not endorsement.
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- Reposted by Adrien LegerOur paper using Oxford #Nanopore direct RNA sequencing to identify m6A modifications on RNA isoforms in human brain is now out in Science Advances. 🧪 www.science.org/doi/10.1126/...
- 🚨 We’re hiring ! 🚨 Join our cutting-edge research team as a molecular biologist at @nanoporetech.com HQ in Oxford. Perfect for a fresh PhD or MSc with a couple of years’ experience. Work at the interface of chemistry, molecular/synthetic biology and AI 👉 ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...
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- Reposted by Adrien LegerDorado is 1.0! 🎉 LC25 release adds v5.2 DNA/RNA models with a new suite of mod models that are higher accuracy, lower FP rates, and significantly faster. - Introducing dorado variant 👀 - HAC error rate is down over 25%. - New 2’Ome mod models - Hopper & Blackwell SUP speed ups #Nanoporeconf
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- Reposted by Adrien LegerReally pleased that this paper is out - academic.oup.com/neuro-oncolo... thanks to all our collaborators far and wide who have helped and of course @nanoporetech.com
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- Reposted by Adrien LegerLive from London Calling 2025! Speakers, attendees and the Oxford Nanopore crew are starting to fill into Old Billingsgate! Ready for Gordon to kick things off for the 11th time! Make sure you keep your posts coming using: #nanoporeconf
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- Reposted by Adrien LegerComputational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:
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- We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing. This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
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- Now that is #epigenetic at scale. I am very exited to see that this partneship with the @ukbiobank.bsky.social will be able to generate SOTA 5mC and 5hmC information with our latest chemistry and mod calling tools 💪
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- Reposted by Adrien LegerExcited to join the #Nanopore Community on BlueSky. Follow us for the latest updates and discussions about Oxford Nanopore and Nanopore Community. #WYMM
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- Reposted by Adrien LegerDespite a massive head start, BlueSky has now overtaken Threads in the US 👇
- Reposted by Adrien LegerNew preprint on our method aa-tRNA-seq: chemically capturing aminoacylated tRNA molecules & pulling them through nanopores. It’s been a blast working with my collaborator Aleks Radakovic to take this from idea to promising pilot data to some looking exciting biology to chase down in future work.
- Reposted by Adrien LegerWe strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
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- It's Christmas in advance with a very special @nanopore.bsky.social #opendata release ! 🎅 We are releasing our 5mC 5hmC 6mA DNA mod synthetic control datasets with each mods in all possible 5 mers contexts. All nicely wrapped in a nice validation blog post. labs.epi2me.io/mod-validati...
