Yoann Gonneau
Exploring Hox genes regulation in Stem Cell-Based Embryo Models at @college-de-france.fr | Duboule Lab | CDSN PhD Fellowship
- Reposted by Yoann GonneauDid you ever wonder how gene expression, once activated, it's maintained for a precise period of time before being decommissioned? Happy to present the final version of our manuscript on the discovery of regulatory trajectories, just published in Nat. Comms: www.nature.com/articles/s41... 1/14
- Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41... Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)
- Reposted by Yoann Gonneau
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔 We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns. buff.ly/w56OUJT - Reposted by Yoann Gonneau🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then! www.science.org/doi/10.1126/...
- Reposted by Yoann GonneauI do like the @dev-journal.bsky.social "Research Report" format for shortish papers This one is valuable. "Is it the N2B27?" is the stem cell biologist version of "Is it the magnesium?" Congrats Tina Balayo @dias-andre.bsky.social David Turner & all authors journals.biologists.com/dev/article/...
- Reposted by Yoann GonneauHappy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social. www.cell.com/cell-reports... Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
- Reposted by Yoann GonneauTranscriptional interferences ensure one olfactory receptor per ant neuron www.nature.com/articles/s41... Caviar for RNA-Seq nerds! Check this out
- Reposted by Yoann Gonneau🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...
- Reposted by Yoann GonneauFully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏 www.crick.ac.uk/careers-stud...
- Reposted by Yoann Gonneau🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/
- Reposted by Yoann GonneauAre digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust
- Reposted by Yoann GonneauEver wondered how to get a gastruloid to grow a head? The Bulut-Karslioğlu lab figured out that by growing different stem cell aggregates in high and low oxygen and later assembling them, you can get gastruloids with a fully formed neural tube. Check out our "In preprints": doi.org/10.1242/dev....
- Reposted by Yoann GonneauAfter nearly twenty years in the making, our attempt at understanding what makes the chaetognath phylum so unique has finally been published! www.nature.com/articles/s41... with #LauraPiovani @dariagavr.bsky.social @alexdemendoza.bsky.social @chemamd.bsky.social and others /1
- Reposted by Yoann GonneauHi bsky! Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity! w/ A. Delahaye & @bensteventon.bsky.social shorturl.at/v01DO
- Reposted by Yoann GonneauHow do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
- Reposted by Yoann GonneauOur work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
- Reposted by Yoann GonneauPaper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
- Reposted by Yoann Gonneau⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
- Reposted by Yoann GonneauIf you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc. app.beetween.com/WeaselWeb/p/... Don't hesitate to apply or share the post !
- Reposted by Yoann GonneauSpotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com! Since the pre-print, we have added many features, notably native 3D detection! @maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social Paper: rdcu.be/epIB7 (1/N)
- Reposted by Yoann GonneauIn which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...
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- Reposted by Yoann GonneauI’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
- Reposted by Yoann GonneauHere it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...
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- Reposted by Yoann GonneauA project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
- Reposted by Yoann GonneauJust in a week from now! Open symposium @collegedefrance.bsky.social in Paris 😎. The state of the art on enhancer sequences. Import tax-free (for everyone).
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- Reposted by Yoann GonneauDifficult to believe that such a community has emerged @ #gastruloids as a model system to explore many aspects of #DevBio. Great to see a room so full of people, curiosity and good Science @prbb.org @upf.edu Thank you to all that have made this possible & of course to the participants
- Reposted by Yoann GonneauSymposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘
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- Reposted by Yoann GonneauLatest from the lab! I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator. However, I was wrong. 1/ www.nature.com/articles/s41...
- Reposted by Yoann GonneauA great opportunity to start your own research group @pasteur.fr in Developmental Biology👇 research.pasteur.fr/fr/call/call...
- Reposted by Yoann GonneauFor some time now we’ve been aware that Chiron #gastruloids, while representing well axial elongation, exhibit a shortage of anterior fates. Here www.biorxiv.org/content/10.1... @Dias and colleagues uncover the reason and explain the implications for our understanding of mammalian gastrulation 🧵
