Marc Bühler
Research Group Leader at FMI, Switzerland | Expert in Gene Expression | Cycling Enthusiast & Rock Climber
Find me on X as @MarcBhler4 or instagram.com/maggi.buehler
- Job opening for one of the most important positions at our institute.
- 📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...
- We are hiring-join us!
- 🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
- preprint alert: www.biorxiv.org/content/10.1...
- The prevailing view is that chromatin remodelers promote transcription factor (TF) binding by making chromatin more accessible. However, this paradigm is reversed in the case of the transcription factor ADNP and the chromatin remodeler CHD4 within the ChAHP complex.
- ADNP binding to chromatin is independent of CHD4, and CHD4’s ATP-dependent remodeling activity is not required for its recruitment to these sites. Instead, CHD4 functions to restrict the access of other TFs, such as CTCF, to ChAHP target sites.
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View full threadKudos to @aheljo.bsky.social and the entire team for this important contribution to our mechanistic understanding of chromatin repression by the ChAHP complex. 🧬👏
- Novel insights into the silencing of an understudied transposable element - check out our latest preprint by @jakobschnabl.bsky.social and colleagues
- 📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:
- Reposted by Marc Bühler
This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!- www.sciencedirect.com/science/arti... I am very excited to share our latest work on the protein and chromatin interactomes of transcription factors! 🧬 Huge thanks to everyone who contributed, especially @csoneson.bsky.social and @mbstadler.bsky.social for driving this story with me! 🙌
- The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team! www.sciencedirect.com/science/arti...
- Reposted by Marc BühlerWe are super excited. The 1st #TriRhena Gene Regulation Club in 2025 will take place this Feb. 5th at @igbmc.bsky.social in Strasbourg. Organizer: @marcbuhler.bsky.social (@fmiscience.bsky.social), @tomsextonlab.bsky.social (IGBMC) & Nicola Iovino (MPI-IE): www.ie-freiburg.mpg.de/gene-regulat...
- Reposted by Marc Bühler📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
