dennis hernaus
Associate prof @ Maastricht University. Neuroscience, drums & hardcore punk.
- Reposted by dennis hernausOnline Now: Pharmacological enhancement of fear extinction
- Reposted by dennis hernaus𝗳𝗠𝗥𝗜 (𝗕𝗢𝗟𝗗) 𝘁𝗿𝗼𝘂𝗯𝗹𝗲𝘀 𝗮𝗴𝗮𝗶𝗻? Something that everyone using fMRI will be hoping is not very solid, please please... Please BOLD don't go down if oxygen metabolism (neurons?) goes up... And it had to affect "default" regions??? doi.org/10.1038/s415... #neuroskyence
- Reposted by dennis hernausThis is an important study but psilocybin potentially promoting brain tumor growth is consistent with human studies suggesting SSRIs may worsen survival outcomes in glioma
- Reposted by dennis hernausYou will find this paper interesting and relevant too: www.biorxiv.org/content/10.1...
- Reposted by dennis hernausNew ENIGMA-CHR study examining network topology differences in 1282 controls and 1582 individuals with clinical high risk for psychosis, led by Drs Siwei Liu, Helen Juan Zhou, Jimmy Lee with @dhernaus.bsky.social, Maria Jalbrzikowski and colleagues. Link to article: www.nature.com/articles/s41...
- Reposted by dennis hernausA new take on the limitations of "psychometric networks" now out in Nature Human Behavior. You don't want to put too much confidence in individual edges. Something we cautioned against in 2017. 1/2 www.nature.com/articles/s41...
- Reposted by dennis hernausPublished now (after long last & 10 citations). Although tVNS does not alter food reward ratings in healthy people, it acutely improved liking ratings in patients with MDD (also correlated with anhedonia). #neuroskyence 🩺 Work w/ @akuehnel.bsky.social www.sciencedirect.com/science/arti...
- Reposted by dennis hernausWith over 7000 participants @ecnp.eu annual meeting in Amsterdam is kicked off by President @martienkas.bsky.social - Congrats to program chair Barbara Franke on an excellent program starting with an impactful keynote from Eveline Crone on the mysterious adolescent brain. #ecnp2025
- Reposted by dennis hernausThis one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯 #neuroskyence #compneurosky doi.org/10.1038/s415...
- Reposted by dennis hernaus'Memento', but it's every plot you make in R
- Reposted by dennis hernaussomehow I missed this! Dopamine represents a domain-general teaching signal: www.science.org/doi/full/10....
- Reposted by dennis hernausLab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n
- Reposted by dennis hernausNew preprint...and this one is truly EPIC 🚨. Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify! Led by @glassybrain.bsky.social #neuroskyence 🩺 osf.io/preprints/ps...
- Reposted by dennis hernausDiscovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice www.cell.com/cell/fulltex...
- Reposted by dennis hernausThis was a fun piece to write
- In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4) #neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
- We used the Maastricht Acute Stress Test to assess cortisol reactivity (peak, turnover, responder status) and measured affect (PANAS), traits (BIS/BAS) and biological & contextual covariates Then we used LASSO regression to find the most robust predictors of cortisol stress reactivity. 🤠 (2/4)
- Findings: 🔽 Positive affect during stress → very modest but consistent predictor of cortisol reactivity. 🔼 Negative affect → only linked to one cortisol metric, not robust. BIS/BAS traits → no association. (3/4)
- We think these results highlight how cortisol stress reactivity is shaped by small distributed contributions across states, biology, and context. No single psychological variable dominates in our sample. This raises questions re psychological interpretations of cortisol reactivity (caution!). (4/4)
- Reposted by dennis hernausHello hivemind! I haven't seen one of these in a while but I know that back-in-the-day they were all the rage: does anyone have a funky spreadsheet of MH/psych/neuro-relevant grants/fellowships for ECRs that they wouldn't mind me sharing with my lab?
- Reposted by dennis hernauscheck out Jake Russin's new paper on how the interplay between in-context and in-weight learning in neural nets can explain tradeoffs in human learning! pnas.org/doi/epdf/10....
- Reposted by dennis hernausMy latest: a short review on latent variable models to help uncover trial-to-trial structure in perceptual decision-making strategies authors.elsevier.com/a/1lMiv4sIRv...
- Reposted by dennis hernausI am delighted to announce registration and abstract submission is open for "The Mechanistic Basis of Foraging 2025" to be held at the Edgbaston Park Hotel, University of Birmingham, UK on 3-5th November 2025. uobevents.eventsair.com/the-mechanis...
- Reposted by dennis hernausAlert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...
- Reposted by dennis hernausOur big behavioral precision mapping preprint is out. Based on 1,486,950 observed choices in a reward learning task, we show that BMI is associated with higher and more variable learning rates. Binge eating was associated with lower reward sensitivity. #neuroskyence 🩺 www.medrxiv.org/content/10.1...
- Reposted by dennis hernausAn Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications. www.nature.com/articles/s41...
- Reposted by dennis hernausWhen I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
- Still open for expressions of interest until June 15th! Do reach out directly (or see link) if you're interested in developing an MSCA-Postdoc. Fellowship application on the (cognitive) neuroscience of motivation/goal-directed behaviour 🧠 👇 #cognitiveneuroscience #Neuroscience #postdoc #cogsci
- Reposted by dennis hernausA Reinforcement Learning and Decision-Making framework for understanding Mental Disorders: osf.io/s58jh
- Reposted by dennis hernausTranscutaneous auricular vagus nerve stimulation (taVNS) and fMRI: a great combination to test the mechanism of action driving stimulation effects 🧠 But how to use the stimulation safely within the magnetic field? We looked into this! #neuroskyence doi.org/10.31234/osf...
- Reposted by dennis hernausSerotonin neurons are known for their puzzling responses to rewards and punishments that don't quite fit with simple theories based on reward, punishment, surprise, salience, or uncertainty. Theories of serotonergic function seem to be diverging over time. efharkin.com/blog/2024-07... 3/6
- Reposted by dennis hernausOut today in American Journal of Psychiatry: psychiatryonline.org/doi/10.1176/... @kurtfraser.bsky.social and I evaluate the Aberrant Salience hypothesis of psychosis in light of the work it inspired over the last 20 years. We still find it ambitious and beautiful, but the devil is in the details
- Reposted by dennis hernausInterested in dopamine? Have fMRI data? We’ve identified a temporal BOLD feature that carries rich information about dopamine physiology. This measure, obtainable from resting-state and task fMRI, opens new ways to indirectly probe dopamine’s role in cognition and disease. 1/n tinyurl.com/bddyz67b
- Reposted by dennis hernaus🥂 IT'S A WRAP !!! 💡ENIGMA's 2024 End-of-Year VIDEO ( youtube.com/watch?v=lJ9E... ) highlights discoveries by 2,000+ scientists from 45 countries, investigating 30+ brain diseases through brain mapping, genomics, environmental studies, treatments, neurostimulation, prevention across cultures (1/n)..
- Reposted by dennis hernausA detailed new look at dopamine signaling suggests neuroscientists’ model of reinforcement learning may need to be revised. #MIT "Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations" #NatureCom www.nature.com/articles/s41...
- Reposted by dennis hernausNothing says cozy reading by the fireplace like our new review, “Molecular heterogeneity and development of the VTA” Thanks @bensaunders.bsky.social and @bellonec.bsky.social for the invitation to contribute to this special issue on #Dopamine! authors.elsevier.com/a/1kIwj8MqMi...
- Reposted by dennis hernausOK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)
- Reposted by dennis hernausMy paper is out!! 🎉 "Opponent control of reinforcement by striatal dopamine and serotonin", @Nature Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain THREAD ⬇️ 1/n
- First pre-print thread here on bsky! We investigated how the acute stress response impacts the allocation of resources (energy) towards safety-related goals. osf.io/preprints/ps... #neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky (1/6)
- We developed a task in which people could choose to exert effort (grip force) to avoid a chance of experiencing an aversive electroshock. Participants were able to trade off the level of physical effort against the likelihood of shock when deciding if they should exert effort. (2/6)
- The acute stress manipulation also seemed to have successfully increased physiological and subjective stress. (3/6)
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View full threadOne of the funnest expts we did in a while. Great to see this out in Communications Psychology now: Acute stress promotes effort mobilisation for safety-related goals. Thanks for the kind and helpful comments from all reviewers 🙏 #neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
- Reposted by dennis hernaus🚨Out in Nature Human Behaviour!🚨 Effort is costly - how can we learn to value doing effortful things? Reward effort, not outcomes/performance! Registered report led by the incomparable Hause Lin shows people can learn to prefer doing effortful tasks doi.org/10.1038/s415...
- Reposted by dennis hernausDynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons https://www.biorxiv.org/content/10.1101/2024.02.22.581563v1
- Reposted by dennis hernausHow do the LC and VTA systems respond to rewards and valence? Our study used high-res fMRI to explore their activation during a reward-emotion recognition task www.biorxiv.org/content/10.1...
- Reposted by dennis hernausWe submitted a revised version today, thanks to @akuehnel.bsky.social's work. I hope it will be published soon. #neuroscience 🩺
- Reposted by dennis hernausI'm elated to share my PhD keystone paper published @PNAS www.pnas.org/doi/10.1073/... I've poured my heart & soul into this project since 2016 (8 yrs!) & I'm happy to introduce the Effort Foraging Task to the world #CognitivePsychology #Motivation #Effort #Foraging #DecisionMaking 🧵
- Reposted by dennis hernausNew paper day! "Multiband acquisition sequences for fMRI: Proceed with caution" apertureneuro.org/article/9129... VERY proud of this one as it's my first editorial piece. Big thanks to @layerfmri.bsky.social and @fmri-today.bsky.social for asking me to do it. #neuroskyence
- Reposted by dennis hernausNew paper out led by Xavier Job at @elife.bsky.social !!! elifesciences.org/articles/90912 We tested two opposing hypotheses of how action influences somatosensory perception! We show that action does not enhance but attenuates self-touch compared to identical touch in the absence of action
- Reposted by dennis hernausLocus Coeruleus Norepinephrine Neurons Facilitate Orbitofrontal Cortex Remapping and Behavioral Flexibility https://www.biorxiv.org/content/10.1101/2023.12.15.571858v1
- Reposted by dennis hernausAnxiety researchers - has anyone tried to recruit hypo-anxious population? (people with very low anxiety) If so, what were your selection criteria? Is there a specific diagnostic tool for this?
- Reposted by dennis hernausThe Drive to Survive: Acute Stress Promotes Aversive Motivation: osf.io/yhqbt/
- Reposted by dennis hernausAfter months of piloting and optimization, we are finally seeing high-quality recordings of tVNS-induced pupil dilation. @akuehnel.bsky.social also set up an automated QC report with several plots and is too humble to brag about it. Work w/ @cecivez.bsky.social #neuroscience
- Reposted by dennis hernausIs the vagus nerve primarily regulating 'rest & digest'? In our new TiCS review, we outline that it is time to expand our perspective on vagal signaling to include 'strive to survive' as a second survival mode. Work w/ @glassybrain.bsky.social #neuroscience authors.elsevier.com/a/1iALr4sIRv...
- Reposted by dennis hernausquick q for universities that require you to sign up to a website to submit your letter of rec: (1) how dare you
- Reposted by dennis hernausGreat open access textbook on experiment design! (h/t @mcxfrank.bsky.social) experimentology.io
