Children's Hospital of Philadelphia Research Institute
Advancing the health of children by turning scientific discovery into medical innovation.
- See the five CHOP Research science stories that engaged you – our community of patient families, colleagues & collaborators – the most this year in our annual end-of-year Cornerstone roundup: ms.spr.ly/63322tar6y
- #ICYMI: Registration is now open for Cores Day on Thursday, September 11th!🥳🎉 @pennmedicine.bsky.social @chopresearch.bsky.social @PennVet @wistar.org -Free registration➡️ tinyurl.com/3bu5pjfd -Event website➡️ tinyurl.com/yc83cmj4
- Mark DeJesse, Senior Clinical Research Financial Analyst at CHOP, has participated as a Philly #Mummer since he was 5! As South Philly Vikings NYB treasurer, DeJesse continues a family legacy. Read our latest #CHOPOffCampus: ms.spr.ly/63320s560w
- Our Cardiac Center is leading research to transform care for children with the most complex heart conditions. With newly awarded grants from Additional Ventures' Single Ventricle Research Fund, CHOP teams are advancing science in key areas like prenatal therapies and AI-powered diagnostics.
- 🚨 NEW RESEARCH! ⚕️ 🩺 Kelchtermans et al. explore how being born early, air pollution, and genetic factors work together to increase asthma attacks in children. bit.ly/47DKjIg @chopresearch.bsky.social #PediatricHealth #AsthmaResearch
- New research out in @Structure_CP provides a structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens ft. @sagargupta.bsky.social (@pennmedicine.bsky.social) & @SgourakisLab (@BB_UPenn) @chopresearch.bsky.social www.cell.com/structure/fu...
- In a guest blog, the Center for Injury Research & Prevention's Associate Director Dr. Rachel Myers writes about 2 new studies on the value + long-term effectiveness of the CHOP Violence Intervention Program, a bridge from the hospital to the community: ms.spr.ly/63321spgQT
- We're inspired by the student trainees in the Center for Autism Research's STAR program, who signed off from their summers at @childrensphila.bsky.social by proposing unique potential research projects on autism spectrum disorder! Learn more about STAR: www.research.chop.edu/services/stu...
- #ICYMI: Registration is now open for Cores Day on Thursday, September 11th!🥳🎉 @pennmedicine.bsky.social @chopresearch.bsky.social @PennVet @wistar.org -Free registration➡️ tinyurl.com/3bu5pjfd -Event website➡️ tinyurl.com/yc83cmj4
- In a new Snapshot Science, learn about CHOP research published in the journal Blood that describes the recovery role of the cytokine tumor necrosis factor alpha (TNFα) for anemia of inflammation. ms.spr.ly/63329sJxiU
- In the journal Pediatrics, CHOP & Penn researchers identify & describe the potential factors that may contribute to eligible infants receiving, or not receiving, nirsevimab, a vaccine to prevent #RSV. ms.spr.ly/63325syk0W
- Researcher in CHOP's Bioengineering & Biomaterials Lab are evaluating different cartilage cell types to improve the current standard of care for #laryngotracheal reconstruction. Learn more: ms.spr.ly/63325sEDYl
- 👏 Congrats to CHOP's Executive Vice President & CSO Dr. Susan Furth on receiving the 2025 Corporate Leadership Award from the Philadelphia Business Journal! Learn more about Dr. Furth: ms.spr.ly/63323sEDcl
- In our latest #CHOPOffCampus blog, Ray Goodridge, Director of Clinical Trials Financial Management at CHOP Research, shares the lore behind his passion for race cars and need for speed: ms.spr.ly/63325sEDi5
- 😎 Meet the 2025 cohort of the Injury Science Research Experiences for Undergraduates (REU) program, a 10-week undergrad internship ft. unique hands-on research experience & mentoring: ms.spr.ly/63326S7DGk
- Researchers at CHOP and St. Jude Research find genetic ancestry influences how gene mutations impact cancer prognosis in patients with T-ALL. The study is the first to explore the impact of genetic ancestry on tumor genomics in T-ALL. Learn more: ms.spr.ly/63321SL0lN.
- Modeling the HLH immune synapse ft. @AFKamenetskii, Hannah Klinghoffer, @varghese_jemy, @DangitVinh, Jeremy Morrissette, @CarolineDiorio, @canna_lab (@chopresearch.bsky.social), @JoeFraietta (@PennMicro) & @JanKarlBurkhar1 (@PennNSG) ashpublications.org/blood/articl...
- In our latest #OffCampus feature, Dr. Valentina Graci, leader of the Sled Lab for Automotive Safety and Rehabilitation Biomechanic, shares how she resets after life in the lab by volunteering as a scuba diver at a local aquarium. Read the full story now: ms.spr.ly/63327SxJKX
- With funding from the Gates Foundation, CHOP's Infectious Diseases Chief Dr. Audrey Odom John + team are advancing the development of a 'malaria breathalyzer' to detect the malaria-causing parasite in asymptomatic patients & reduce transmission. Learn more: ms.spr.ly/63325SxyBS
- In a new Cornerstone blog, read about studies from CHOP's Dr. Bev Davidson & team highlighting how several AAV capsid variants could improve the precision of gene therapy for neurodegenerative disorders: ms.spr.ly/63328SWf56
- .@kiranmusunuru.bsky.social (@penngenetics.bsky.social/ @PennCardiology), @ahrensnicklas.bsky.social (@chopresearch.bsky.social) & colleagues raced against time to deliver a life-saving, 1st-ever personalized gene editing therapy for a 9-month-old patient with CPS1 deficiency tinyurl.com/3ncxd5ex
- For #MentalHealthAwarenessMonth, we're launching a story series focused on #BehavioralHealth research across the lifespan. Starting with #infancy, learn about Dr. Wanjikũ F.M. Njoroge's work studying the pandemic's effect on children + caregivers: www.research.chop.edu/cornerstone-...
- At the #PreschoolAge, children begin to make choices but also potentially display challenging behaviors. Our Where Discovery Leads series highlights a #PositiveParenting program led by @childrensphila.bsky.social PolicyLab's Dr. Joanne Wood about this stage: www.research.chop.edu/cornerstone-...
- Children often first encounter challenging interpersonal situations like #bullying at school. At @childrensphila.bsky.social , Dr. Tracy Waasdorp tests a #virtualreality program to help students & teachers improve social emotional learning: www.research.chop.edu/cornerstone-...
- CHOP researchers are partnering with the University of Pittsburgh to enhance the identification and management of #Depression & suicide risk in #Adolescents in primary care. Learn more: www.research.chop.edu/cornerstone-... #MentalHealthAwarenessMonth
- Congratulations to the 2025 winners of our Research Excellence at CHOP (RE@CH) Award: Katelynn Stanley (Genetics), Jamillah Millner (Injury Research), & Lauren Mitteer (Endo) for their valuable contributions as clinical research staff! ms.spr.ly/63326SiLnK
- To better understand why some #Neuroblastoma treatments fail, CHOP's Dr. Kai Tan + team created a first-of-its-kind longitudinal cell atlas. This multidimensional dataset illustrates how tumor microenvironments tumors evolved after chemotherapy: ms.spr.ly/63326SZC0G
- A new study from our Cancer Center features our patient Edie & her mom, Emily, who both have hereditary neuroblastoma. The findings demonstrate that ALK inhibition therapy is effective in managing the disease, which could help establish a new standard of care. More: ms.spr.ly/63326Sk9pu.
- Hello from #ASGCT2025! Visit our team at booth 1315 in the Exhibit Hall.
- CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments. Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
- A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F #ASGCT2025 #MedSky @asgct.bsky.social
- In a landmark scientific feat published in NEJM, a CHOP & Penn Medicine team treated the first patient with personalized #genetherapy, designed uniquely for newborn KJ, who was diagnosed with a rare #ureacycledisorder at birth. Learn more: ms.spr.ly/63327Sw92F
- Over 275 caregivers & community members currently participate in the CHOP Research Family Partners Program, working with investigators to ensure research is relevant, ethical, & impactful. Learn more from one family partner, Erica Evans: ms.spr.ly/63327SZt4J
- Today we celebrate our clinical research professionals at @childrensphila.bsky.social with the Annual Research Excellence (RE@CH) Awards and Recognition Event! Meet this year's nominees for the 2025 RE@CH Award and stay tuned for our three recipients: files.constantcontact.com/6e43b4a7201/...
- Our May featured #FacultySpotlight is Dr. Ana Cristancho, CHOP neurologist. In her Q&A, Dr. Cristancho discusses her work investigating the mechanisms underlying the long-term effects of early-life brain injuries. ms.spr.ly/63325SZSdd
- The @childrensphila.bsky.social & Penn community is invited to stop by our first PDSS 2025 event! From 2:30 to 4PM today in the CTRB Lobby, researchers will be sharing their scientific posters. Check out a full agenda for May 6, 7, & 8 here: pdss.research.chop.edu/agenda.php
- Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring ft. Wenbao Yu, Rumeysa Biyik-Sit, Chia-Hui Chen @KaiTanLab1 (@chopresearch.bsky.social/ @pennmedicine.bsky.social) & Yasin Uzun (Penn State) www.nature.com/articles/s41...
- A grant from the National Heart, Lung, & Blood Institute supports CHOP research to develop a #precisionmedicine approach to better match #SickleCellDisease patients with compatible blood donors. Read more on our Cornerstone blog: ms.spr.ly/63324SRnlK
- A pioneering #cancer treatment for solid high-risk tumors developed with CHOP researchers could overcome the disadvantages of traditional chemotherapy. Learn more about PEEL-224: ms.spr.ly/63320SKYgY
- To our CHOP research community: Join us May 6, 7, & 8 for our annual Research Poster Day and Scientific Symposium! 🧬 The entire CHOP community is invited to attend. Learn more: ms.spr.ly/63329SH1nF
- ft. G. Blizard, C. Hou, @etersque_jean, @RHMachLab, @sellmyerlab.bsky.social (@PennRadiology), G. Dwivedi, Y. Pan, H. Ni, B. Davis, @drewweissmanlab.bsky.social, M. Alameh (@penn-id.bsky.social), H. Said (@chopresearch.bsky.social) & Q. Cao (@dbei-upenn.bsky.social) www.nature.com/articles/s41...
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- A pioneering #cancer treatment for solid high-risk tumors in development with CHOP researchers could overcome the disadvantages of traditional chemotherapy. Learn more about PEEL-224: www.research.chop.edu/cornerstone-...
- Meet Dr. Jessica Foster, our April #FacultySpotlight. At CHOP, she studies the application of CAR T cell therapy for brain & spinal cord tumors in children. Read the full Q&A: ms.spr.ly/63325qFM63
- Could a genetic approach be viable for some #growthdisorders like #achondroplasia? CHOP's Lefebvre Lab studies the mechanisms of a gene responsible for skeletal growth. Learn more on Cornerstone: ms.spr.ly/63326qL5ZO
- 📽️ In our newest #LabLife video, step into the lab of Dr. Douglas C. Wallace, a @childrensphila.bsky.social geneticist & evolutionary biologist who founded the field of #MitochondrialMedicine 40 years ago. Watch the full video now: www.research.chop.edu/video/lab-li...
- Our 2025 CHOP #WomenInSTEM video gallery is live! On Cornerstone, read a summary of the advice shared by seven individuals nominated for their excellence + inspiration:ms.spr.ly/63326qWsQw
- This #WomensHistoryMonth, featured research trainee Dr. Rochelle Glover, a postdoctoral research fellow in the Zackular Lab, encourages celebration of women’s contributions to science. Read the full Q&A : ms.spr.ly/63323qYKtc
- Join @penncancer.bsky.social & @chopresearch.bsky.social April 30th-May 2nd for Cellicon Valley '25: The Future of Cell & Gene Therapies! Learn more & register➡️ www.med.upenn.edu/cellicon25/
- We've received a transformational gift from Aileen and Brian Roberts and their family to support the creation of Roberts Children’s Health at CHOP. The inpatient complex includes a 20-story tower and a revitalization of our existing hospital. More: ms.spr.ly/63323quD9f.
- Our CHOP Leukodystrophy Center of Excellence recently held its 2025 GLIA Scientific Meeting & Advocacy Workshop, bringing together clinicians, researchers, advocacy leaders, regulatory officials, & industry partners from around the world. Learn more: ms.spr.ly/63320q3Yt0
- Surprising insights from CHOP's John Lab show how a novel prodrug strategy for treating #malaria could help researchers design more effective drugs for the deadly disease. Learn more about the PNAS study in a new Snapshot Science blog: ms.spr.ly/63325qJHSW
- With new funding from the NIH & the Dravet Syndrome Foundation, CHOP's Dr. Ethan Goldberg and team are testing an advanced genome editing approach to treat #DravetSyndrome. Learn more: ms.spr.ly/63328qJHUu #GeneTherapy #Epilepsy #Seizures
- Vote for us now in STAT Madness 2025! The bracket-style contest captures the best innovation in science & medicine. This year, STAT selected CHOP research that could advance next-generation gene therapies for hemophilia: ms.spr.ly/63326qHfRy
- ✅ Day 1 of a #Postdoc recruitment summit hosted by CHOP's Office of Academic Training & Outreach + Talent Acquisition + Cell Biology/Genomics RAG is underway! Talented scholars join us on campus today + tmrw for talks, tours, & more. careers.chop.edu/us/en/event/... @childrensphila.bsky.social
- Our next #FacultySpotlight, Dr. Emily Kuschner, is dedicated to filling gaps in #autismresearch to ensure treatments & interventions can be tailored to each individual. Learn more about Dr. Kuschner's research in her new Cornerstone Q&A: ms.spr.ly/63324qEmxM
- 🦓 Today is #RareDiseaseDay & CHOP came together to #ShowYourStripes! DYK CHOP has discovered more than 50 genes associated with rare disease?! We'll be sharing pics of our stripes all day. Up first: Our Undiagnosed Disease Program ❤️ @chopcareers.bsky.social @childrensphila.bsky.social
- Our CHOP #ShowYourStripes showcase continues with members of our CHOP #Mitochondrial Medicine Frontier Program! Thank you for all that you do to advance rare & undiagnosed disease research. #RareDiseaseDay
- More #RareDiseaseDay support from folks at CHOP's IMGC Genetics team! Thank you for taking the time to #ShowYourStripes ❤️🦓
- This #BlackHistoryMonth, our featured #researchtrainee is Dr. Rasheed Sule, who studies Fontan-associated liver disease (#FALD) at @ChildrensPhila. In his Q&A, Dr. Sule describes his work, passion for mentoring, & "the beauty of diversity". ms.spr.ly/63327UCUrD
- New #FanconiAnemia research funded partly by CHOP's Cell & Gene Therapy Collaborative illustrates how a novel in vivo #GeneTherapy strategy could hold promise for patients. Learn more: ms.spr.ly/63323UfrHf
- Applications are now open for our CHOP-RISES High School #SummerInternship program providing #STEM pathways to Philly students! Apply before the deadline on Friday, March 28, 2025, at 11:59 PM. Learn more below and on our site: ms.spr.ly/63326UNWky
- Congrats, Dr. Corwin! At @childrensphila.bsky.social, Dr. Corwin studies pediatric concussion, particularly the diagnosis & initial management of concussions in kids using specialized exam techniques. Learn more: www.research.chop.edu/people/danie...
