Climate Change and Maternal Child Health Lab
Laboratory of Srimonta Gayen, Associate Professor, IISc Bangalore.
Interests: DevBio | epigenetics | X-chromosome inactivation/upregulation | DNA/RNA modifications | environment-epigenome crosstalk | ageing
- Reposted by Climate Change and Maternal Child Health LabNew paper: Remodeling of XIST regulatory landscape during primate evolution We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells. urlr.me/eyG38M @manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social
- Fascinating story from Shiv and team!
- Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer 👉 nature.com/articles/s41586-025-09899-8
- Reposted by Climate Change and Maternal Child Health LabNow final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...
- Reposted by Climate Change and Maternal Child Health LabGlad to share our latest work that came out recently. We dive into the mechanisms of how Transcription Factors (TFs) like the nuclear receptor, ERα navigate the genome to find their targets.
- Reposted by Climate Change and Maternal Child Health LabEpigenetics Update - H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations bit.ly/459lS3k Robert Schneider (Helmholtz München) in Mol Cell #Epigenetics #Chromatin #Metabolism --- Discover the breakthrough at epigenometech.com
- Reposted by Climate Change and Maternal Child Health LabVery happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
- Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re... @isscr.org 🧵
- 🧵(1/n) Acknowledge IISC_Bangalore, @embo.org, @insdb.bsky.social ,ANRF_India, DBT_India for their support.
- 🧵(2/n) Key highlights of this work: 1. m⁶A is not essential for maintaining X-inactivation 2. X-linked RNAs carry less m⁶A than autosomal RNAs in embryonic lineages
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View full thread🧵(4/n) Thanks to other contributors of this work @amritesh-iisc.bsky.social and Murali. Special thanks to my collaborator Kartik Sunagar. Grateful to the reviewers and editors for their guidance throughout the process. #Epigenetics #StemCell #RNAmodification #m6A
- Elated to share that @sharmistasbio.bsky.social from our lab presented her work on #epigenetic regulation of neurodevelopmental disorders recently at the #BuildingBrains2025 workshop at @iBRIC-inStem. Acknowledge @iiscbangalore, @embo.org, @ANRF-India, @DBTIndia for the support.
- Reposted by Climate Change and Maternal Child Health LabWe are excited to share our new preprint: SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids. www.biorxiv.org/content/10.64898/2025.12.01.691499v1
- Reposted by Climate Change and Maternal Child Health LabSo exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...
- XCI-ited to share that @Runumi from our lab recently attended the Gordon Research Conference on "Epigenetic Variation: Mechanisms and Impact across Systems" held in Barcelona, Spain. She presented her work on role of #m6A-RNA in #embryogenesis and dosage compensation #X-inactivation.
- Special thanks to @Anusandhan National Research Foundation (ANRF), @Department of Biotechnology (DBT) Govt. of India, @Indian Institute of Science Bangalore, and @embo.org for the support.
- Thrilled to share that @Avinchal from our lab presented her work on effect of heat-humidity stress on fetal development and #epigenetic regulation in the recent #GordonConference on "Epigenetic Variation: Mechanisms and Impact across Systems" #ClimateChange #GlobalWarming #MaternalChildHealth
- Special thanks to @Anusandhan National Research Foundation (ANRF), @Department of Biotechnology (DBT) Govt. of India, @Indian Institute of Science Bangalore, and @embo.org for the support.
- Interesting study showing how H3K36me2 modulation is critical for post-implantation DNAme re-establishment. #epigenetics #histone #EarlyDevelopment
- Epigenetics Update – Reprogramming of H3K36me2 guides lineage-specific post-implantation de novo DNA methylation go.nature.com/43jkfzm #Epigenetics #DNAm #H3K36me2 #Development --- High-resolution insights without cell sorting; epigenometech.com
- Reposted by Climate Change and Maternal Child Health LabExcited to receive the Best Poster Award at the 9th Asian chromatin meeting 2025 in IISER Pune! Huge thanks to my mentor Srimonta for his guidance. Thanks to organizers of #ACM2025 for this wonderful opportunity! #iiscbangalore #EMBO
