Francesco Costa
- Reposted by Francesco Costa[Not loaded yet]
- ⚠️⚠️⚠️Preprint alert⚠️⚠️⚠️ We mapped intramolecular isopeptide bonds across the AlphaFold database and found that they are widely distributed in microbial surface proteins, such as fibrillar adhesins or pilins, suggesting new targets for broad-spectrum antimicrobial strategies.
- 📢 Just published! Introducing Isopeptor: a computational tool for detecting intramolecular isopeptide bonds in protein structures with high precision and recall. academic.oup.com/bioinformati...
- 🧬 Isopeptor enables reliable detection and geometry evaluation of these covalent links using a template-based strategy powered by pyJess. 🔍 The tool demonstrates a precision of 1.0 and recall of 0.947 in identifying incorrectly modelled isopeptide bonds in PDB structures.
- Check out this article about my research at @embl.org where I focus on protein modelling and on the study of fibrillar adhesins. Recently, we developed a method to detect isopeptide bonds, a key stabilizing feature in bacterial proteins. Thanks @oanastroe.bsky.social for putting this together!👇 👇 👇
- Reposted by Francesco Costa[Not loaded yet]
