ChemSyBio - Berteau Lab - Univ Paris-Saclay, INRAE
Enzyme mechanisms, Structural Biology, Microbiome - Université Paris-Saclay, @univparissaclay.bsky.social, INRAE, @inrae-france.bsky.social, MICALIS institue, ChemSyBio Laboratory
micalis.fr/equipe/chemsybio/
- From labeled CO2 to CN! Our approach towards electrophilic cyanation is out in @jacs.acspublications.org! Great collaboration with Fabien Caillé! Congrats Maxime Alexandre and all co-authors! 🍾👏 pubs.acs.org/doi/full/10.... #isotope #C14 #C11 #cyanation @agencerecherche.bsky.social @erc.europa.eu
- Registration is now open for @keystonesymposia.bsky.social "Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection." Deadline for scholarships and abstract selected short talks is Jan 7! Join us this May for an amazing meeting! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
- Prix Nobel de physique 2025 : décerné aux chercheurs britannique John Clarke, américain John Martinis & français Michel H. Devoret, qui a fait une partie de ses études & notamment son doctorat à l’UPSaclay (ex. UPSud), par l’Académie royale des sciences de Suède à Stockholm. 🔗 tinyurl.com/482fbw37
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- Unimolecular and Bimolecular Pathways in Bidirectional Redox Molecular Catalysis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
- ⚡🌩️ From molecular to flow-cell: Our latest paper shows cobalt(III)triphenylcorrole for CO2 reduction to CO and methanol now out in ACS Catalysis. In collaboration with ICMUB bourgogne congratulations @afrza686.bsky.social @ajeetsinghm.bsky.social Bishnu and Marcello @ipcm-sorbonne.bsky.social
- is the dimer core of the H-cluster of FeFe hydrogenase formed by rSAM chemistry in HydE? pubs.acs.org/doi/full/10....
- 💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve. Preprint 📝: biorxiv.org/content/10.1... 🧵 1/n
- 🦠🧍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...
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- We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design! github.com/martinpacesa...
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- Computer algorithms have designed highly efficient synthetic enzymes from scratch go.nature.com/43PmE5s
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- Radical SAM #enzyme & #antibiotic biosynthesis: ArsL, a novel [4Fe-4S] enzyme, cleaves the central S-adenosyl-L-methionine (SAM) cofactor to generate the 3-amino-3-carboxypropyl #radical instead of the 5′-deoxyadenosyl radical (5'-dA). Amazing team work! Check out: pubs.acs.org/doi/10.1021/...
- Our work on the synthesis of sceptrin, ageliferin, nigramide R, chabamide and others by photo(flow)catalysis are now on ChemRxiv. urlr.me/aJfu4r Congratulations to Mohammed Latrache & Amina Sesay @univparissaclay.bsky.social. Great collaboration with @arseniyadis.bsky.social @hiltonlab.bsky.social
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- Spectroscopic and Biochemical Characterization of the Noncanonical Radical SAM Enzyme ArsL, Involved in Arsinothricin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
- 💊 Researchers at Institut Curie, @cnrs.fr and @inserm.fr have developed a prototype drug that destroys refractory cancer cells by degrading their membranes. 🎥 Dr Raphaël Rodriguez tells us more on video ⤵️ ℹ️ Read the scientific publication in Nature: www.nature.com/articles/s41...
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- This is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.
- I'm truly excited to announce our new publication in @nature.com unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @rnfr2d2.bsky.social for the fantastic illustration! LINK: www.nature.com/articles/s41...
- Evolutionary-scale prediction of atomic-level protein structure with a language model | Science www.science.org/doi/10.1126/...
- Excited to share our new preprint: AI-guided Antibiotic Discovery Pipeline from Target Selection to Compound Identification! It includes a comprehensive benchmark of structure-based drug design (SBDD) methods and presents a full, practical pipeline for antibiotic discovery. arxiv.org/abs/2504.11091
- Curious about using artificial intelligence to boost your research? Here are the programs you shouldn’t miss go.nature.com/3RFlouC
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- SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx | mBio journals.asm.org/doi/10.1128/...
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- Save the date in Nashville!
- New review out in @NatureRevMicro on the complex rltnshp btween metabolism & AMR! A true labor of love from previous postbac Mehrose, grad students Varun & Zirui, and collaborator @drrobsmith.bsky.social (plus figures I'll likely use for many talks to come 😊) rdcu.be/eaES2
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- Finally out in #mBio, @asm.org ! Great collaborative work linking enzymes, microbiota and SARS-CoV-2 infectivity. #microbiota, #enzyme, #radicalsam journals.asm.org/doi/10.1128/...
