Carlo Camilloni
Associate professor at the University of Milano.
Biophysics and computational structural biology.
http://compsb.unimi.it
Developer @plumed.org
orcid.org/0000-0002-9923-8590
- Reposted by Carlo CamilloniNo joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...
- Reposted by Carlo CamilloniCan proteins fold and function with half of the amino acid alphabet? Using only 10 residues, we designed stable, mutation-resilient structures—no aromatics or basics involved. A minimalist foundation for ancient biology and synthetic design. tinyurl.com/37t8br4v #ProteinDesign #OriginsOfLife
- Download it here: www.tandfonline.com/eprint/DUBR5...
- Electric field-induced destabilization and surface modulation of Aβ42 fibrils in molecular simulations: theoretical implications for direct current stimulation in Alzheimer’s disease www.tandfonline.com/doi/full/10....
- Electric field-induced destabilization and surface modulation of Aβ42 fibrils in molecular simulations: theoretical implications for direct current stimulation in Alzheimer’s disease www.tandfonline.com/doi/full/10....
- Reposted by Carlo CamilloniExcited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors. ter.li/of4cgh
- Targeting the histone‐fold dimerization interface of oocyst rupture proteins from Plasmodium berghei for antimalarial inhibitor discovery - Ballabio - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/full/10....
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- Reposted by Carlo CamilloniI just published: ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building. medium.com/p/erc-plus-j...
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- Reposted by Carlo CamilloniNew preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
- Reposted by Carlo CamilloniI fully endorse this. Political leaders are falling prey to AI hype, and seem to lack any kind of help from reputable sources who could counter the false claims of tech CEOs. Where are their science advisers???
- In a short piece for @techpolicypress.bsky.social, @abeba.bsky.social and I write #AIHype Is Steering EU Policy Off Course. Stop peddling in unscientific discourse about “AGI” and “superintelligence.” Serve citizens. Don't cater to the whims of tech CEOs. www.techpolicy.press/ai-hype-is-s...
- Reposted by Carlo CamilloniThe idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
- Reposted by Carlo CamilloniA new tutorial manuscript is out! 🚀 Making @plumed.org fly: a tutorial on optimizing performance, by Daniele Rapetti, @bonomimax.bsky.social @carlocamilloni.bsky.social @bussigio.bsky.social and Gareth Tribello. arxiv.org/abs/2511.02699
- Reposted by Carlo CamilloniIt’s official: ChatGPT can't draw a GPCR, but you’ll master them in the Filizola Lab 😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research
- Reposted by Carlo CamilloniI'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se
- We asked what a strong static EF may do to AB42 fibril, we saw a marked perturbation of the fuzzy coat and increase fluctuations of the fibril core
- Reposted by Carlo CamilloniApple is entering the protein folding arena. SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
- Reposted by Carlo CamilloniRFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders. Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others! Check it out: lnkd.in/eiUFfJaM.
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- Reposted by Carlo CamilloniRosettaFold 3 is here! 🧬🚀 AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release! Congratulations @simonmathis.bsky.social and team!!! ❤️ bioRxiv preprint: www.biorxiv.org/content/10.1...
- Reposted by Carlo Camilloni🚀 Super excited to share our new work, led by @vschnapka.bsky.social bAIes, a Bayesian framework for generating accurate atomic-resolution ensembles of IDPs using #AlphaFold info! Now on @biorxivpreprint.bsky.social → feedback welcome! @pasteur.fr @erc.europa.eu www.biorxiv.org/content/10.1...
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[Not loaded yet] - Reposted by Carlo CamilloniChoose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF
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- onlinelibrary.wiley.com/doi/10.1002/... Federico did some modeling to make some hypothesis on the interaction of anthocyanin with glucose transporter
- Protein folding, binding and redox conditions by Stefano Gianni team in Rome the super productive Valeria Pennacchietti, doi.org/10.1016/j.ij...
- Very proud of Amit Kumawat, Elisa Tavazzani and all coworkers for this work on hERG K+ channel rescue mechanism by ICA. Now published here: jbiomedsci.biomedcentral.com/articles/10....
- Amit Kumawat, Elisa Tavazzani and all collegues from Silvia Priori group combined in vivo, in vitro and molecular dynamics to show how some severe LQT2 mutations in hERG potassium channel can be rescued using ICA, a potent hERG activator. www.biorxiv.org/content/10.1...
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- Very true!
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- Reposted by Carlo CamilloniRun BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations. Thanks @jjimenezluna.bsky.social for the help! 🌐 colab.research.google.com/github/sokry... 📄 www.biorxiv.org/content/10.1...
- Reposted by Carlo CamilloniWe’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk. @bindresearch.org is hiring across the board: bindresearch.org/careers/ #compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
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- Reposted by Carlo CamilloniChimeraX can run Foldseek to find similar structures, such as distantly related homologs, and analyze the results, for example, mapping all ligands onto your query structure. Here are ligands mapped onto Nipah virus G protein. www.rbvi.ucsf.edu/chimerax/dat...
- Reposted by Carlo CamilloniThe paper describing our community effort to collect and organize #plumed tutorials has been published in the Journal of Chemical Physics, as part of the Michele Parrinello Festschrift! doi.org/10.1063/5.02...
- Reposted by Carlo CamilloniIn this world of shrinking research budgets, academic layoffs and failing universities, Elsevier is still making an obscene profit. If anything has radicalised me to green it's these numbers. www.researchprofessionalnews.com/rr-news-worl...
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- Reposted by Carlo CamilloniWe’re thrilled to announce the launch of Bind Research, the UK’s first not-for-profit Focused Research Organisation, with long-term support from the Department for Science, Innovation and Technology’s Research Ventures Catalyst Programme, industry, and charities.
- Published in JCIM, #compchem pubs.acs.org/doi/full/10....
- Estimation of ligand binding free energy using multi-eGO. | ChemRxiv - go.shr.lc/46lUbUl atomistic, accurate, and fast, what else? Super work from Bruno Stegani, Emanuele Scalone, Fran Bacic Toplek, Thomas Löhr, Stefano Gianni, Michele Vendruscolo and Riccardo Capelli
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- Reposted by Carlo Camilloni📢 New #preprint describing our community effort to share #plumed tutorials arxiv.org/abs/2412.03595 ! Explore the tutorials at www.plumed-tutorials.org
- Stefano Gianni in Rome has led this cool protein folding work that shows a complex relationship between folding of multiple domains and binding of an autoinhibitor element doi.org/10.1002/pro....
- Reposted by Carlo CamilloniWe strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
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- Bluesky now has over 10 million users, and I was #2.246.645!
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- British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/... we contributed to this work with some molecular insight
- Estimation of ligand binding free energy using multi-eGO. | ChemRxiv - go.shr.lc/46lUbUl atomistic, accurate, and fast, what else? Super work from Bruno Stegani, Emanuele Scalone, Fran Bacic Toplek, Thomas Löhr, Stefano Gianni, Michele Vendruscolo and Riccardo Capelli
- Light chain dimers in native conditions are not all the same, check what we found! #alAmyloidosis
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- Amit Kumawat, Elisa Tavazzani and all collegues from Silvia Priori group combined in vivo, in vitro and molecular dynamics to show how some severe LQT2 mutations in hERG potassium channel can be rescued using ICA, a potent hERG activator. www.biorxiv.org/content/10.1...
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- Reposted by Carlo CamilloniCASP16 will start later this year, so to celebrate that here is a short thread on the uncanny valley separating experimental structures & computational models of proteins. Even though the latter are extremely accurate, there are still some weird differences that are hard to pin down. 🧪🧶🧬🧵
