Joachim Nielsen
Associate Professor in Muscle Physiology and Metabolism. University of Southern Denmark.
- Reposted by Joachim NielsenFor ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
- Reposted by Joachim NielsenMitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...
- Reposted by Joachim Nielsen📄 New preprint Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans. 👇 Link in first comment #Physiology #Diabetes #Mitochondria #Metabolism
- Reposted by Joachim NielsenAcute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis physoc.onlinelibrary.wiley.com/doi/10.14814...
- Reposted by Joachim Nielsen⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
- "We find that when glycogen stores are present, they provide remarkable resilience to dopamine nerve terminal function under extreme hypometabolic conditions, but ... impairment of access to glycogen, makes them hypersensitive to fuel deprivation." www.pnas.org/doi/suppl/10...
- Reposted by Joachim NielsenThis ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. buff.ly/hFHjKy9
- Reposted by Joachim NielsenSuper happy to share our latest study on muscle remodeling in human cachexia in patients with lung cancer: www.biorxiv.org/content/10.1...
- Reposted by Joachim NielsenFinally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
- Reposted by Joachim NielsenFirst post on Blue Sky New pre-print! Does muscle remember disuse muscle wasting? Our new study shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy. Aged muscle shows exaggerated susceptibility. doi.org/10.1101/2025...
- Reposted by Joachim NielsenExcited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...
- Reposted by Joachim NielsenIT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
- Reposted by Joachim NielsenHopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28... @jphysiol.bsky.social
- Reposted by Joachim NielsenThis article is a homecoming for me. As a PhD student, I focused on the growth-rate transcriptional regulation in yeast. Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues. www.biorxiv.org/content/10.1...
- Reposted by Joachim NielsenIs Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China. My slides can be viewed here: www.linkedin.com/posts/javier...
- Reposted by Joachim NielsenManuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit
- Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit biorxiv.org/content/10.1101/202…
- The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B) - Donoghue - 2025 - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Joachim NielsenNew #scisignal paper: Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke. #Myoblue tinyurl.com/bddss3j6
- Reposted by Joachim NielsenExcited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. www.nature.com/articles/s41...
- Our new preprint! Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density. www.biorxiv.org/cgi/content/... Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense. 🧵 Thread below…
- Until 2017, the prevailing consensus was that mitochondrial cristae density remained unchanged with training. However, in a cross-sectional study, we observed that endurance-trained athletes had a 25% higher cristae density compared to untrained individuals: 10.1113/JP273040
- At that time, we had biopsies before and after 10 weeks of aerobic training but found no effect of training on cristae density, raising questions about its plasticity.
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View full threadThe data show that eight weeks of HIIT training led to a 7% increase in mitochondrial cristae density, demonstrating cristae plasticity. Importantly, this plasticity was also observed in patients with type 2 diabetes, highlighting its relevance for metabolic health.
- Reposted by Joachim NielsenCheck out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake. www.biorxiv.org/content/10.1...
- Reposted by Joachim NielsenDoes biological sex impact the rate of intrinsic mitochondrial respiration in the presence of creatine in human skeletal muscle? Emily J. Ferguson (@queensuresearch.bsky.social) et al. investigate! 📜 buff.ly/46B6lzL
- Reposted by Joachim NielsenMechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism biorxiv.org/content/10.1101/202…
- Divergent Changes in Peak Fat Oxidation and Fatmax Following 3-Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge onlinelibrary.wiley.com/share/CDCGW2...
- Reposted by Joachim NielsenSarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...
- Reposted by Joachim NielsenCongrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic www.sciencedirect.com/science/arti...
- Reposted by Joachim Nielsen🚨 The last paper of my PhD is out in @MSSE Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners 🙏🏻 Rich Blagrove & Jonathan Folland Temporary free download. 🔗 journals.lww.com/acsm-msse/ab... 🧵 1/7
- Elegant study on glycogen using the one-legged exercise model: Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans Thomassen, McKenna, Olmedillas, Wyckelsma, Bangsbo, Nordsborg www.frontiersin.org/journals/phy...
- Reposted by Joachim NielsenCongratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science www.europeandiabetesfoundation.org/recipients/e...
- Join our PhD course in metabolism and EC coupling. November 10-15. University of Southern Denmark. Enrol here: www.sdu.dk/en/forskning...
- Reposted by Joachim NielsenNew paper! Do ketone esters affect post-exercise recovery? doi.org/10.1007/s003... #ketones #exercise #sports #nutrition #recovery
- Reposted by Joachim Nielsen“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...
- Reposted by Joachim Nielsen#Research by Léo Blervaque et al. examines #capillary-to-sarcolemma distance and location of cytochrome c oxidase, offering insights for maximal O2 uptake and muscle lactate release in trained athletes 🚴♂️ 🔎 📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
- Reposted by Joachim NielsenThe Hands-On Growth Laws Theory Cookbook doi.org/10.48550/arX...
- Reposted by Joachim NielsenMicrotubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Joachim NielsenStructure and function of the neuromuscular junction in health and myasthenia gravis www.sciencedirect.com/science/arti...
- Reposted by Joachim NielsenMorphological differences in myofibre size and shape: A comparative study of the soleus, gastrocnemius, triceps brachii and vastus lateralis in humans and mice onlinelibrary.wiley.com/doi/10.1111/...
- Reposted by Joachim NielsenI love the idea of "micropublications" www.micropublication.org (preparing one now)
- Reposted by Joachim NielsenCommentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science www.nature.com/articles/s41...
- Happy to share my article as part of the Journal Club series in @natrevendo.nature.com where I discuss about the emerging role of #glycogen #metabolism as an important #signaling molecule regulating energy homeostasis in adipose tissue. nature.com/articles/s4157…
- Reposted by Joachim NielsenOur department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!
- News from our lab: 4 weeks of altitude decreases skeletal muscle mitochondrial cristae density in humans (but mitochondrial respiration increased). Great work by Camilla Schytz, Carsten Lundby, and colleagues. doi.org/10.1152/japp...
- Capillary‐to‐sarcolemma distance and location of cytochrome c oxidase: Insights for maximal O2 uptake and muscle lactate release in trained athletes - Blervaque - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/abs/10.1...
- Reposted by Joachim NielsenThe Illusion of Simplicity in Therapeutic Exercise Therapeutic exercise requires personalization, supervision, and continuous adaptation. Read how we took this into account in our Nature Medicine paper www.nature.com/articles/s41...
- Reposted by Joachim NielsenAltered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise onlinelibrary.wiley.com/doi/10.1111/...
- Please consider to join us in Odense, Denmark, for this PhD course @myoblue.bsky.social
- PhD-course (Nov 2025) “Muscle metabolism and E-C coupling – role in performance, fatigue and disease”, covering aspects of regulation of muscle function at rest and during exercise. www.sdu.dk/en/forskning...
- Reposted by Joachim NielsenNEW: Statement from the PCI RR Managing Board on the withdrawal of Infant and Child Development as a PCI RR-friendly journal, and the decision by Wiley to refuse preprints that have been peer-reviewed by @peercommunityin.bsky.social / @pci-regreports.bsky.social Read here ➡️ osf.io/tn8mh
- Reposted by Joachim NielsenAn automated screening process provides new insights into the impact of abnormal structures known as micronuclei.
- Reposted by Joachim Nielsen“[Of] 25 replication studies, 7 (28%) studies demonstrated robust replicability, meeting all three validation criteria: achieving statistical significance (p < 0.05) in the same direction as the original study and showing compatible effect size magnitudes as per the Z test (p > 0.05).”
- New Replication Project in sport and exercise science shares it results: Out of 25 replication studies performed, 56% yielded significant results, but only 7 (28%) revealed a similar effect size. Several problems related to the quality of are discussed. link.springer.com/article/10.1...
- Reposted by Joachim NielsenFantastic demonstration of expansion microscopy in skillfully dissected human tissue structures. One more example proving what a versatile imaging method ExM is. 👇🏾
- Our latest: Quantitative details on lipid droplet-mitochondrial contact in human skeletal muscle doi.org/10.1152/ajpc...
- Reposted by Joachim NielsenThis great editorial clearly explains the Peer Community In (PCI) initiative. It’s from @psych.peercommunityin.org, but it applies to all PCI communities: doi.org/10.31234/osf...
- Reposted by Joachim NielsenA tour de force! Mouse, worm, and human data all telling the same story. Amazing! “microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism” www.sciencedirect.com/science/arti...
- Reposted by Joachim NielsenChronic resistance and endurance training alters the way in which motor unit discharge rates are modulated across contraction intensities, suggesting alterations in net excitatory synaptic input - another fun collaboration with @jskarabot.bsky.social and colleagues. www.biorxiv.org/content/10.1...
- Reposted by Joachim NielsenProud to share our work unraveling the cellular mechanisms of skeletal muscle regeneration in older adults. Using spatial and single-cell transcriptomics, we tracked human muscle biopsies post-injury and identified key cellular interactions in aged regeneration 📄 www.nature.com/articles/s41...
- Ever considered cardiovascular involvement in glycogen storage diseases? See our latest work (also with TEM images): rdcu.be/epzLd Grateful to Thomàs Pinós, Richard Cubbon, and Alejandro Lucia for leading this work — and thanks to co-authors, reviewers, and the editors at @natrevcardiol.nature.com
- Reposted by Joachim NielsenPreprint Alert We present the most comprehensive, time-resolved atlas of the human proteomic response to acute exercise. We mapped 10,000+ proteins across plasma, saliva & urine—3,000+ changed after just one workout. doi.org/10.1101/2025... Explore cbmr-rmpp.shinyapps.io/exerome/
- Reposted by Joachim NielsenHighlighting our latest research. Deconvoluting insulin signaling in human skeletal muscle. www.news-medical.net/news/2025052...
- Reposted by Joachim NielsenThrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell. @annakrook.bsky.social @juleenrzierath.bsky.social @cbmr.science doi.org/10.1016/j.ce...
- Comparison of Phasic Store‐Operated Calcium Entry in Rat Slow‐ and Fast‐Twitch Muscle Fibers - Lilliu - 2025 - Acta Physiologica - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
- Reposted by Joachim NielsenThe Influence of Sex on Fiber-Specific Indices of Oxidative Capacity in Human Skeletal Muscle journals.physiology.org/doi/abs/10.1...
- Reposted by Joachim NielsenOur new durability paper is out in SJMSS! We tested how endurance performance determinants change after heavy-intensity running (90 and 120 min) in well-trained marathoners. 📌Below details of what we’ve found. 🆓 Open-Access 📄 onlinelibrary.wiley.com/doi/10.1111/... 🧵1/14
- Reposted by Joachim NielsenMolecular machineries shaping the mitochondrial inner membrane.
