Mikel Lavilla-Puerta
Oxygen, yeast, SynBio and sometimes, plants. Postdoc at Oxford Biology, PhD at Scuola Superiore Sant'Anna.
I also sing and am very fond of my village.
- Reposted by Mikel Lavilla-Puerta#ThrowbackThursday to last week Thursday at #ISPLORE2025JP where we took a group picture of our fantastic community. Missing those conferences vibes? Scroll back through the #ISPLORE2025JP hashtag for some of the best moments 🌱🌊
- Reposted by Mikel Lavilla-Puerta#ISPLORE2025JP is over.. but not before a comedy performance and closing ceremony by the organizers Mikio Nakazono and Moto Ashikari 😆 Thanks so much to all organisers and sponsors for making this edition possible. It was truly amazing! Next edition reveal by @djgibbs.bsky.social: #ISPLORE2028UK
- Reposted by Mikel Lavilla-PuertaComing to you live from #ISPLORE2025JP Fresh preprint from my lab showing that leaves progressively oxygenate and how this is important for their morphogenesis.Thanks to our collaborators from @Fra_LicO2si lab. #plantscience www.biorxiv.org/content/10.1...
- Reposted by Mikel Lavilla-PuertaWe finish this #ISPLORE2025JP session with exceptional talks by @mikellavi.bsky.social, Daai Zhang, @vinayshukla.bsky.social and Lina Zhou 🌱🌊 Check out @beagiuntoli.bsky.social's recent preprint #plantscience www.biorxiv.org/content/10.1...
- Reposted by Mikel Lavilla-PuertaThe speed of hypoxia: great talk by @mikellavi.bsky.social at the @isplore.bsky.social conference in Nagoya!
- Reposted by Mikel Lavilla-PuertaA synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
- Preprint alert! 🗞 We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄. We can now control yeast growth through oxygen! But most importantly, Here's a very short recap of what we understood thanks to it: biorxiv.org/content/10.110…
- The Cys N-Degron Pathway (which controls plant responses to hypoxia) works in coordination with many, many other processes that finely tune low O2 responses. We took it. Put it in yeast, where no such regulation exists. And it still works! So the Cys-NDP is self-sufficient...
- Thanks to this yeast system we understood: 1] The Cys-NDP is responsible for these responses in plants happening in only 5-10min. 2] HRPE elements (in hypoxic promoters) compete for ERFVII TFs when these are limited. The more HRPEs, the faster the response!
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- Reposted by Mikel Lavilla-PuertaHonoured & excited that ‘Breathing Underground’ has been funded by the ERC! This will let me explore one of the most fundamental questions of plant life: how roots breathe underground? @erc.europa.eu
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- The real deal on the topic of plant hypoxia, SynBio and orthogonality. How to use these three concepts to build new oxygen-sensitive circuits? Don't miss the thread below!
- Reposted by Mikel Lavilla-PuertaPreprint alert, please share!! With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
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