I am just going to plug-in the latest paper from our lab, wherein we show that treatment with the chemotherapy agent 5-Fluorouracil (5-FU) induces ribosome collision and that RQC pathway mitigates the 5FU-induced cytotoxicity.
#RNA,
#RNASky,
#Cancer
academic.oup.com/nar/article/...
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Abstract. Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5
