Emil Marklund
Assistant Professor at @scilifelab.se and @stockholm-uni.bsky.social. Intrigued by what makes life work at the molecular level.
- 📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social www.cell.com/cell/fulltex... Key findings in a thread (1/6):
- 🧬 Differences in DNA binding affinity are driven by differences in motif recognition. This is the same binding mechanism that we previously found for the bacterial TF l𝘢𝘤 repressor, which is structurally dissimilar to KLF1, implying a universal mechanism across domains of life and TF types. (2/6)
