Miguel Angel Contreras Sieck💀🧬🦴🇵🇸
Antropólogo enfocado en evolución humana, genética cuantitativa de fenotipos complejos y el desarrollo de paleogenómica ética y sustentable en México. PhD Candidate en la UMN en el AnthGenLab!!
- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸Job alert! 3 year post doc in my research group at University College London working on Roman Leather via biomolecular archaeology. #ZooMS #stableisotopes www.jobs.ac.uk/job/DQJ187/r...
Research Fellow in Biomolecular Archaeology at UCL
Searching for an academic job? Explore this Research Fellow in Biomolecular Archaeology opening on jobs.ac.uk! Click to view more details and browse other academic jobs.jobs.ac.uk - Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸US higher ed is under attack. Harvard refusing Trump's unreasonable, lie-based, often illegal demands is making a difference. I especially appreciate how @ryanenos.bsky.social explains that research grants aren't favors, they're competitive contracts serving national priorities as set by Congress.
- "We are now in a system of competitive authoritarianism. And it’s just about whether we manage to take our democracy back from that." On the pod, @ryanenos.bsky.social is so good on Harvard pulling back from surrender to Trump, and on need for institutions to fight: newrepublic.com/article/2061...
Trump Spirals Into Crazed Fury After Harvard Humiliates Him Very Badly
As Trump rages at Harvard over leaks that he’s backtracking in his fight with the university, a Harvard political scientist explains why the stakes in this battle are far bigger than they seem.newrepublic.com
Genetic formation and regional disparities of Kra-Dai and Hmong-Mien speakers inferred from ancient genomes of cave burial populations in southwest China
Abstract. Cave burial is a funerary practice believed to be associated with modern Kra-Dai (KD) and Hmong-Mien (HM) speakers for thousands of years. Howeveacademic.oup.comHomo luzonensis and the role of homoplasy in the morphology of hominin insular species
Homo luzonensis lived during the upper Pleistocene in the northern Philippines, east of the Wallace line. The few specimens attributed to this species show a mosaic of plesiomorphies for the genus Ho...onlinelibrary.wiley.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸Replying to Catherine RampellFlorida is trying to do the same thing btw www.insidehighered.com/news/quick-t...
Florida Proposes H-1B Hiring Ban at All Public Universities
All Florida public universities would be banned from hiring foreign workers on H-1B visas under a policy change that the Florida Board of Governors will consider next week.insidehighered.com Whole-genome sequencing provides insights into the evolutionary adaptation and conservation of gibbons
Gibbons are small, arboreal apes that play a critical role in tropical biodiversity and ecosystem ecology. However, nearly all species of gibbons are …sciencedirect.com- Evaluating the effects of archaic protein-altering variants in living human adults | Science Advances www-science-org.ezp2.lib.umn.edu/doi/full/10....
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www-science-org.ezp2.lib.umn.edu Tracing the evolutionary histories of ultra-rare variants using variational dating of large ancestral recombination graphs
Ultra-rare variants dominate whole-genome sequencing datasets, yet their interpretation is limited by allele frequency, which provides little information at very low counts and is highly sensitive to ...biorxiv.orgThe primate Major Histocompatibility Complex as a case study of gene family evolution
The Major Histocompatibility Complex region evolves via gene birth-and-death, resulting in short-lived genes, rapidly expanding gene subfamilies, and many gene fragments.elifesciences.orgLeveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits
Zhu et al. present scalable approaches for leveraging genealogical graphs to study complex traits. They introduce ARG-RHE, a method for heritability estimation and gene-based association testing that,...cell.comHabitat Mosaic Limits Gene Flow and Promotes Morphological Adaptation in a Generalist Mammal
We investigated how fine-scale habitat heterogeneity influences genetic structure in the European wood mouse by sampling individuals across hedgerow, forest edge, and inner forest habitats in three N....onlinelibrary.wiley.comOptimising Genome‐Wide Detection of Runs of Homozygosity: Impacts of Reference Genome Quality and Sequencing Parameters on Inbreeding Assessment
Inbreeding and inbreeding depression pose a critical challenge to the persistence of small and isolated populations, driving the need for precise assessment of genomic metrics. Genome-wide runs of ho...onlinelibrary.wiley.comhttps://www.biorxiv.org/content/10.1101/2025.11.26.690513v1
biorxiv.org- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
The emergence and diversification of dog morphology
Dogs exhibit an exceptional range of morphological diversity as a result of their long-term association with humans. Attempts to identify when dog morphological variation began to expand have been con...science.org- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
A simple analytical model for Neanderthal disappearance due to genetic dilution by recurrent small-scale immigrations of modern humans - Scientific Reports
Scientific Reports - A simple analytical model for Neanderthal disappearance due to genetic dilution by recurrent small-scale immigrations of modern humansnature.comDeciphering the genetic diversity in the Arabian Peninsula and Africa: insights from Y-STR data - Forensic Science, Medicine and Pathology
Middle Eastern and African populations make up a significant portion of the global population and exhibit substantial genetic diversity. However, genetic studies on these populations have been largely...link.springer.com- Techbros and AI trying lo revive Phrenology??? I mean why not, every day seems like a worst Black Mirror episode on and on...
Lessons learned: Recommendations for reproducible paleogenomic data analyses
Souilmi et al. propose essential guidelines to improve the reproducibility of paleogenomic data analysis. As ancient DNA research often relies on the destructive sampling of finite resources, these re...cell.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Modelling approaches for meta‐analyses with dependent effect sizes in ecology and evolution: A simulation study
In ecology and evolution, meta-analysis is an important tool to synthesise findings across separate studies and identify sources of heterogeneity. However, ecological and evolutionary data often e...besjournals.onlinelibrary.wiley.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...journals.plos.orgAccelerated evolution increased craniofacial divergence between humans and great apes | Proceedings of the Royal Society B: Biological Sciences
The level of craniofacial diversity of hominids (the group that includes great apes and humans) is much higher than that of their sister group, the hylobatids (also known as gibbons or lesser apes), d...royalsocietypublishing.org- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸Aaaannnddd I messed up the link. Here it is. doi.org/10.1101/2025...
The inhibitory cascade model and evolution in segmentally organized tissues
The inhibitory cascade model (ICM) of morphogenesis is an effort to link development to the production of variation, which can influence evolutionary trajectories. The ICM proposes that serially devel...doi.org- Are you interested in tooth evolution and evodevo? Ben Auerbach and I would like to direct your attention to our new preprint “The inhibitory cascade model and evolution in segmentally organized tissues.” www.biorxiv.org/content/10.1... 🦴🐭🐒🧪🦷🧬 @nsvitek.bsky.social @kevinlala.bsky.social
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institutionbiorxiv.org
An early East Asian lineage with unexpectedly low Denisovan ancestry
Yang et al. study Denisovan ancestry in ancient and present-day humans. In contrast to other East Asians, genomic comparisons suggest that the Jomon derived most of their ancestry from a deep lineage ...cell.comA high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...biorxiv.orgLong shared haplotypes identify the southern Urals as a primary source for the 10th-century Hungarians
Genome-wide ancient DNA data from early medieval populations across the broader Ural region and adjacent areas identify the southern Urals as the primary ancestral source of 10th-century Hungarians.cell.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Client Challenge
nature.comMicrobiome characterization of a pre-Hispanic man from Zimapán, Mexico: Insights into ancient gut microbial communities
The research of microbiome derived from mummified human remains, coprolites and paleofeces has gained significant interest over several decades, aiming to elucidate the evolution of microbial interact...journals.plos.orgA cautionary note on using STRUCTURE to detect hybridization in a phylogenetic context
Using simulations, we provide the first systematic evaluation of the performance of STRUCTURE under a variety of cross-species hybridization scenarios. We find that STRUCTURE performs well in identif...onlinelibrary.wiley.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Deep history from the genomes of India
People carrying Neanderthal mixture entered the subcontinent after 50,000 years ago, meeting Denisovansjohnhawks.net- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)
The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies
Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correlaacademic.oup.com - Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Accelerated Bayesian inference of population size history from recombining sequence data - Nature Genetics
Population history learning by averaging sampled histories is a new Bayesian method for estimating historical effective population size from recombining sequence data that offers improved speed and ac...nature.comHomo sapiens, Neanderthals and speciation complexity in palaeoanthropology
Abstract. Tracking the origins of new species and delimiting taxa across space and time present well-trodden sources of controversy for palaeoanthropology.academic.oup.comResolving out of Africa event for Papua New Guinean population using neural network - Nature Communications
Here the authors reveal that a strong bottleneck and slow growth of ancestral effective population size in Papua New Guinean populations can be mistaken for admixture with an earlier out-of-Africa pop...nature.comVirtual Anthropology and the Subadult Virtual Anthropology Database |
The Subadult Virtual Anthropology Database (SVAD) is a unique repository of standardized data collected from digital images (e.g., CT scans, conventionaltaylorfrancis.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Mammoths in Mexico? Huge bone trove reveals giant beasts thrived in warmth, too
Fossils found while building airport contain first mammoth DNA from tropical locationscience.orgColumbian mammoth mitogenomes from Mexico uncover the species’ complex evolutionary history
Paleogenomic studies suggest that Mammuthus columbi derives from an ancient hybridization between Mammuthus primigenius and Mammuthus trogontherii. While its habitat spanned from North to Central Amer...science.orgPNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...pnas.orgThe genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility
Ancient DNA from the Southern Caucasus reveals remarkable genetic continuity, with some mixing from Anatolia/Iran and the Eurasian Steppe, and shows that even periods of urbanization and increased mob...cell.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Alcohol and the rise of complex societies
A cross-cultural study reveals how the consumption of wine and beer facilitated the evolution of human societiesmpg.de- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans
Ancient DNA has revolutionized our understanding of human evolutionary history, but studies focusing solely on genetic variation tell an incomplete story by neglecting phenotypic outcomes. The relatio...biorxiv.orgPhylogenetically informative proteins from an Early Miocene rhinocerotid - Nature
Protein sequences from fossil tooth enamel of a rhinocerotid from Canada’s High Arctic are used to develop phylogenetic frameworks from a specimen too old to preserve ancient DNA.nature.comHidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations
The extent to which genetic effects vary across ancestries remains a central question in human genetics, with direct implications for improving polygenic prediction. Recent studies have found that ave...biorxiv.orgWhole-genome ancestry of an Old Kingdom Egyptian - Nature
Whole-genome sequencing of an ancient male Egyptian revealed a mixture of North African Neolithic and eastern Fertile Crescent ancestry, suggesting human migration between Egypt and Mesopotamia by the...nature.comMetaGLIMPSE: Meta Imputation of Low Coverage Sequencing Data for Modern and Ancient Genomes
The advent of efficient and accurate imputation for low coverage sequencing offers an unbiased alternative to SNP array imputation, increasing the accuracy of rare variant imputation across all popula...biorxiv.orghttps://www.pnas.org/doi/10.1073/pnas.2503748122
t.coGenomic profiling of a six-generation patrilineal family of the Ming-Qing Dynasty in China
Family cemeteries from historical periods often follow structured burial patterns, but identifying these arrangements is challenging due to limited wr…sciencedirect.comGenetic Insights into Ancient Kinship and Human History: Methods, Applications, and Implications
Recent advances in ancient DNA analysis have transformed our understanding of kinship and underlying social structures in past populations. The application of next-generation sequencing technologies h...sciepublish.comFirst ever skull from ‘Denisovan’ reveals what ancient people looked like
Ancient proteins and calcified dental plaque identify heavy-browed fossil from China as a Denisovan.nature.comThe proteome of the late Middle Pleistocene Harbin individual
Denisovans are a hominin group primarily known through genomes or proteins, but the precise morphological features of Denisovans remain elusive due to the fragmentary nature of discovered fossils. Her...science.orgDenisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium
A mitochondrial genome from Middle Pleistocene hominin dental calculus from northeastern China clusters with mtDNAs of early Denisovan individuals in Siberia, linking a nearly complete cranium to Deni...cell.comMajor expansion in the human niche preceded out of Africa dispersal - Nature
Analysis of species distribution models in a pan-African database comprising chronometrically dated archaeological sites over the past 120,000 years shows major expansion in the human niche from 70 ka...nature.com- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸[Not loaded yet]
- Reposted by Miguel Angel Contreras Sieck💀🧬🦴🇵🇸📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
Males weren’t always bigger than females in this hominid species
Molecular evidence from a 2-million-year-old southern African hominid species indicates sex and genetic differences in P. robustus.sciencenews.org- Colossal scientist now admits they haven’t really made dire wolves www.newscientist.com/article/2481...
