Prof Deepak Modi
Faculty at ICMR-NIRRCH 🇮🇳 Developmental biologist, embryo implantation, placentation and sex determination
We also develop organ on chip and organoids models of ♀️ rep tract and placenta
#womenshealth #gender #hoxgenes
🏳️🌈
- 2 new studies from the lab show that early pregnancy needs inflammation but only briefly. When uterine inflammation does not activate in time, implantation fails and if prolongs pregnancy is lost. Links doi.org/10.1093/reprod… doi.org/10.1016/j.lfs.��� Super proud of my team
- Republic Day Greetings
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- Regulation of embryonic ploidy by meiotic recombination.. expected ? Unexpected? www.nature.com/articles/s41...
- WHO statement on notification of withdrawal of the United States share.google/nfdhuCJAQrzW...
- Elated to share the publication of our paper on how HOXA10 controls NLRP3 to drive #hybridEMT and pyroptosis for embryo implantation #Inflamation #pregnancy #reproduction academic.oup.com/reproduction...
- Reposted by Prof Deepak ModiWoolly Rhino was not experiencing population decline prior to its rapid extinction ~14,000 years ago, based on DNA recovered from mummified wolf stomach in Siberian permafrost. Instead, extinction likely due to rapid environmental change. 🧪🌎🧬🖥️ #EvoSky #Genomics pmc.ncbi.nlm.nih.gov/articles/PMC...
- Reposted by Prof Deepak ModiTylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring A new review of the evidence just out www.thelancet.com/journals/lan...
- The serenity of the city called Bhubaneswar
- Reposted by Prof Deepak ModiInterested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
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- Indias position statement on the use of niPGT for clincial use is published in JHRS and covered by the media #ivf #fertilityclinic #embryo #genetics www.ndtv.com/health/india...
- The year 2026 opens with a bang Thrilled to share the publication from the lab showing that an inflammation is essential for embryo implantation #fertility #miscarriage #uterus #infertility www.sciencedirect.com/science/arti...
- The year closes with a key policy paper. India issues its position statement on non-invasive PGT (niPGT). Based on available data of 3000 embryos an expert review panel concludes that niPGT is not ready for clinical use for embryo selection. journals.lww.com/jhrs/fulltex...
- Techniques, methods papers and software papers are bound to be higher on scoreboards and there are no prizes for guessing that. For which direction the science is moving .. ideal would be to look at highly cited original papers and look at field normalised citations. www.nature.com/articles/d41...
- The sun kissed evening. Chasing the sun across the horizon. Watching the world trade its gold for midnight sapphire at 30,000 feet. There’s a certain kind of magic between sun, clouds and the sky. #WindowSeatViews #DuskTillDawn #SkyAesthetic #GoldenHourMagic #HorizonLines
- Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR @osvaldoics.bsky.social #INSDBISD2025
- Elected at the executive council of Society for Reproductive Biology and Comparative Endocrinology #SRBCE Looking forward to ser6ve the society and taking Indian science to the international map
- Batch 1 and batch 2 to off to IISER Bherampur for the coveted and much awaited meeting of the Indian Society of Developmental Biologist #InSDB 2025 Excited to present our groups work on embryo implantation and placental organ on chip and placentoids models
- Some beautiful insights into the genomics of #Preterm births. Key SNPs in the maternal genome are strongly associated with Preterm delivery in the Indian population. Dr Arindam Mitra BRIC-NIBMG at #ReproNext2025 #SRBCE2025 #prematurity
- A phenomenal keynote address by #padmashree Dr Neerja Bhatla on cervical cancer screening and prevention at the #ReproNext2025 and 42nd annual meeting of #SRBCEn2025
- The inauguration of ReproNext 2025 begins It's also the 42nd annual meeting of SRBCE #ReproNext2025 #SRBCE2025
- Hot from the lab Our #preprint describing how #inflammation is controlled at #embryo implantation and it's defect leads to placental dysregulation and #miscarriage www.biorxiv.org/content/10.6...
- We need to make a framework for both preclinical and clinical testing of drugs in pregnancy
- Reposted by Prof Deepak ModiCan't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄 Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...
- Reposted by Prof Deepak ModiAttending #Cellbio2025? I am presenting two posters, stop by if you are interested in epithelial dynamics. Looking forward to all the amazing conversations and feedback!!
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- Thrilled to share our review on predicting endometrial receptivity non invasively link.springer.com/article/10.1...
- Our work on genetic switch in embryo implantation covered by Indian news media The Times of India timesofindia.indiatimes.com/city/mumbai/...
- Thrilled to share our discovery on the genetic switch that creates a hybrid EMT state for embryo implantation. This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles www.nature.com/articles/s41...
- Super tired after a 3 day long marathon meeting ... But it's satisfying when the job gets done
- An AI based tool that predicts assisted reproduction outcomes in infertile men with a genetic cause #infertility #ivf #male link.springer.com/article/10.1...
- This is super amazing. The choices that we make are innate to us, social determinants shape that further. This study in show that genes influence the tendencies, which through social and structural context, determine our educational choices and outcomes. www.nature.com/articles/s41...
- Organ on chip require close coordination of engineers & biologists. Discussed the evolution of this collaboration leding to placenta on chip development with Prof Abhijit Majumder at IIT B. Keeping attention of engeneering and getting them interested in biological nuances is a challange but exciting
- I hate mondsys to begin with but the end of the day is satisfying as I spend the rest of the day looking the work done by my labmates and help them to make the plan for the comming week.
- I am sure the Indians will get this joke It doesn't matter what you eat between Dhanteras and Bhai Dhooj What matters is what you eat between Bhai Dhooj and Dhanteras #DiwaliMasti 😬😬😀😀 Ps Copied as recived
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- We wrote this review for medical students to summarise the diagnostic criteria and pathophysiology of #endometriosis fertilityscienceresearch.org/a-primer-on-...
- A lazy sunday and a talk on genetics of infertility is both exciting and boring
- Reposted by Prof Deepak ModiSuccess. Nearly 259 Foldscope deployed in hands of unsuspecting candy crazy kids. Halloween is always more colorful with the microscopes - specially in a few weeks they could look at the micro-fauna of the teeth with so much sugar consumption.
- Science needs to be part of our day to traditions. For many years - I have continued to give Foldscope @teamfoldscope.bsky.social with the candy on Halloween. Try it out and surprise the kids with the capacity to see and discover real #microMonsters crawling on our planet. 🎃👻 #FoldscopeHalloween
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- Look who called me 🤣🤣🤣
- Reposted by Prof Deepak Modi📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social! We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos. Check out the 🧵 👇 @mpi-cbg.de @poldresden.bsky.social
- Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...
- Here is a review, where we summarised role of HOX genes in adult tissue From it's role in segmentation, in adult uterus it acts like a signalling regulator and its disruption is associated with endometrial pathologies like #endometriosis and endometrial #cancer. link.springer.com/article/10.1...
- Genetically controlled induction of menstruation in the mouse is a game changer for both basic and applied research in endometrium and it's disorders. A really amazing model and a great resource Kudos @cagricevrim.bsky.social and team for this. Very excited www.biorxiv.org/content/10.1...
- Reposted by Prof Deepak ModiMy institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15. www.mskcc.org/research/ski...
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