Gokul Upadhyayula
Asst Prof of Molecular and Cell Biology, UC Berkeley
Scientific Director, Advanced Bioimaging Center
- Reposted by Gokul Upadhyayula🔬🔦Check out our ‘Imaging spotlight’ on Volumetric Imaging via Photochemical Sectioning (VIPS) from @ruixuan3.bsky.social, Srigokul Upadhyayula and colleagues. VIPS helps researchers scale super resolution imaging to large whole-mount tissues. focalplane.biologists.com/2025/12/02/i...
- Reposted by Gokul Upadhyayula(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
- Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
- www.science.org/doi/10.1126/... Cover: 3D WT bulb, wedge-out view; VIPS alternates light-sheet imaging & photochemical sectioning. #ExM #LLSM #imaging #neuroscience
- This work was made possible in part by support from @czbiohub.bsky.social @cziscience.bsky.social @sloanfoundation.bsky.social, @berkeleylab.lbl.gov, @hhmi.org, @nersc.bsky.social, Philomathia Foundation and NIH.
- Reposted by Gokul UpadhyayulaAdaptive optical vision Fourier transformer (AOViFT): a machine learning framework for inferring image aberrations and restoring diffraction-limited performance. www.nature.com/articles/s41...
- Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. MOSAIC captures everything from subcellular dynamics to neural activity in live mice. www.biorxiv.org/content/10.1...
