Portugues Lab
Official account of the Portugues Lab @Cornell (previously @TUM), studying all things sensorimotor in larval zebrafish.
- Reposted by Portugues LabNature research paper: Plastic landmark anchoring in zebrafish compass neurons go.nature.com/4qP4HwB
- 1/6: New publication from the lab: “Plastic landmark anchoring in zebrafish compass neurons” by Ryosuke Tanaka (@ryosuketanaka.bsky.social) and Ruben is available here: rdcu.be/eX1L4
- 2/6: This study shows that the heading direction (HD) network in larval zebrafish can use visual cues, both landmarks and optic flow, to track orientation in visual environments. Landmark tracking requires an intact projection from the “visual” habenula to the interpeduncular nucleus (IPN).
- Reposted by Portugues Labwww.cell.com/cell/fulltex... We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -
- 1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.
- 2/n: Heading direction networks (HDNs) are biological instantiations of ring attractors (RAs), but there are different classes of RAs that incorporate angular velocity signals in different mechanistic ways.
- Reposted by Portugues LabAdam Kampff’s passion for understanding and explaining the world was unmatched. Living by example and not ever compromising on his dreams, Adam was uncanny in making people realize they can learn and understand anything and everything. Keep his dream alive! In his own words: tinyurl.com/ye29csw3
- Reposted by Portugues Lab*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️
- (1/n) We are excited to share our new paper in Nature Communications, by Hagar Lavian (@hlavian.bsky.social) and team, revealing how the zebrafish brain integrates visual navigation signals! www.nature.com/articles/s41...
- (2/n) We discovered that navigationally relevant visual signals are topographically organized in the interpeduncular nucleus (IPN) and aligned with the heading direction signal.
- Reposted by Portugues LabThrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
- Reposted by Portugues LabPreprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...
- Reposted by Portugues LabApplication is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!
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- @natrevneuro.nature.com just published a beautiful cover for the issue that includes the recent review on analogies in the visual system of vertebrates and invertebrates (@ryosuketanaka.bsky.social). Read it here doi.org/10.1038/s415... Science and Art, what could be better?
- Reposted by Portugues LabLet's share @etlunsford.bsky.social's work : to survive, animals avoid drifting involuntarily in their environment. While humans rely on visual & vestibular cues, birds & fish need to sense complex flow changes of the external fluid (air/water) around them to select motor actions. How do they do?(1)
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- Are you interested in visual systems? How are they similar or different across species? Read the review by Ryosuke @ryosuketanaka.bsky.social and Ruben published today in @natrevneuro.nature.com. It is available here: rdcu.be/enlpC
- Reposted by Portugues LabIntroducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...
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- 1/3 Starting this summer, and after 11 wonderful years in Munich, the Portugues Lab will be starting a new adventure at the Department of Neurobiology and Behavior (NBB) (nbb.cornell.edu) at Cornell University in Ithaca, NY.
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- Reposted by Portugues LabNew preprint: a simple method (ADePT) for optical control and recording of activity by axially-decoupling the focal planes for widefield patterned photo-stimulation and two photon imaging. Proof-of-principle analysis of functional connectivity in the olfactory bulb. 1/7 #neuroscience
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- Reposted by Portugues LabHere it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. @portugueslab.bsky.social. 1/3
- Reposted by Portugues LabWe’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin
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- Interested in research in freely-moving mice? Apply for a PhD or postdoc in the lab of Weijian Zong @weijianzong.bsky.social in beautiful Trondheim, Norway, to use the miniature two-photon microscopes he developed. Exciting research, wonderful environment, great PI. www.jobbnorge.no/en/available...
- Reposted by Portugues LabCalling all neuroscientists! 🧠 The MBL's 2025 Neural Systems & Behavior course is accepting applications until February 1. Don't miss your chance to apply! Read more: bit.ly/4jetcAc #ScienceStartsHere
- Reposted by Portugues LabInterested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th!
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- 1/3 How does visual input affect the heading direction (HD) network? In our latest lab preprint, Ryosuke presents "visual landmarks" to larval zebrafish and shows that the HD network tethers to the visual environment. The experiments are again inspired by the beautiful recent work in Drosophila.
- 2/3 The study shows that: - the same HD neurons track two different visual scenes - introducing two identical visual landmarks "confuses" the network => plastic - optic flow can affect the representation of heading - the visual information is conveyed to the network from the dorsal habenula
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- Is your summer 2025 looking boring and monotonous? Apply to the Neural Systems and Behavior course (www.mbl.edu/education/ad...) at MBL in Woods Hole for an 8-week experience that will change your (scientific) life. Deadline: Feb 1st, 2025.
