Florian I. Schmidt lab
Cell Biology meets Immunology and Virology, spiced up with nanobodies
- Early weekend read: Our new review on #antiviral #inflammasomes spearheaded by Jennifer Wuerth with some recommendations for inflammasome detection is out! @unibonn.bsky.social @immunosens.bsky.social www.mdpi.com/1999-4915/18...
- Reposted by Florian I. Schmidt labCryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
- Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells @unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
- We constructed reporter poxviruses to track inflammasome assembly in human primary cells ....
- ... identified #nanobodies that block AIM2 inflammasomes by interfering with AIM2 Pyrin filament oligomerization (sequences deposited in nanosaurus.org data base) ...
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View full threadThe reporter is described here: www.biorxiv.org/content/10.1...
- Reposted by Florian I. Schmidt labLooking for passionate candidate to apply to PhD fellowship to University of Murcia call: www.um.es/documents/d/... Interested students contact me!
- Reposted by Florian I. Schmidt lab🚨 New in The EMBO Journal! Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins. 🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social 📄 www.embopress.org/doi/full/10....
- Thrilled to start the 2nd Bonn #Organoid Day with more than 100 participants at @unibonn.bsky.social!
- First talk by Christian Liemersdorf from @dlr-de.bsky.social about organoid in space - great fun at full house (first time I have seen every single spot of the lecture hall taken)
- Reposted by Florian I. Schmidt lab[Not loaded yet]
- Reposted by Florian I. Schmidt labDavid Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...
- Reposted by Florian I. Schmidt labHurray! ImmunoSensation will go on! 🥳 The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded! Let us #celebrate 7 more years of #immunology in #Bonn 🎉 www.immunosensation.de/news/immunos...
- Reposted by Florian I. Schmidt labWant to live a longer and better life? Give creative people resources to make your life better. Harvard.edu
- This work was spearheaded by @florianngohr.bsky.social at @unibonn.bsky.social. He is an outstanding immunologist/virologist currently looking for #postdoc opportunities!
- Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...
- Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...
