David Solecki
Posting our lab life studying the neuronal cytoskeleton and chromatin with cool microscopes🔬Proud #GenX, #firstgen college, #intj @RITscience @stonybrooku Alum
Verified: orcid.org/0000-0001-8481-0403
- Viruoso snow shoveler reporting for duty ❄️🔥 You can take the boy out of #Buffalo, but you can't take the Buffalo out of the boy….even in #Memphis. Not sure what’s more annoying: the plastic shovels sold here or the cat overlord side eye 😒
- Mind blown 🤯 from Chris Laumonnerie's talk at our Department seminar! Newborn neurons in the developing brain aren't just cholesterol consumers... they're active PRODUCERS too! 💥 Paired with a brand-new biosensor that lets us watch this cholesterol economy in real time: slick data incoming 🤩
- In uncertain times, it’s grounding to be reminded what still works. 💪 A strong score doesn’t drop alone. It reflects: team that execute, collaborators elevating the work & peers valuing rigorous work Surrounding yourself with phenomenal people + doing work you actually care about… is what’s needed
- Me: Scores won’t post for 2 business days (Tuesday next week). Also me: refreshes eRA Commons every 7 minutes 🫠 Curse you, random SRO who posted early that ONE time. #science #grantlife #pilife
- Reposted by David SoleckiNew on bioRxiv! 🧠🧬 Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly #Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
- Today felt like a marathon I didn’t sign up for… and then the sky handed me a gold medal for finishing anyway. 🌅✨ #SunsetHealing #LifeLately #YouAreEnough #DecemberVibes
- Reposted by David SoleckiRivero-Ríos, Sutton, Weisman and colleagues show that PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025
- Parked my vehicle in the loading zone for 45 minutes and STILL no ticket 😂💀 When you absolutely, positively have to be 0.3 seconds closer to the door. #thursdayvibes #thursdayfun #BringYourOwnTraffickCones
- Reposted by David SoleckiHelp chromatin friends! Looking for a paper and AI is failing. Study used CRISPR tech to perturb a variety of chromatin regulators to determine their functional importance on a number of different TFs. Main outcome was that different TFs = different chromatin regulators
- Thanksgiving update: Turkey’s brined. Pie’s baked. Pickle slice just hit metaphase. Breaks from cutting edge science? Never heard of ’em. Happy Thanksgiving y’all 🥒🔬🦃 #Thanksgiving #CellBiology #NerdHumor #Science
- Reposted by David SoleckiThrilled to share the first full paper from @AntLabUNAM! 🐜💥 Our paper examines how queen and worker harvester ants differ in ovarian morphology and gene expression, shedding light on the ovary as a hub for multiple physiological systems, not just reproduction. Check it out! rdcu.be/ePNP8
- Reposted by David SoleckiThis work is now out @pnas.org. Result of fantastic collaborations with @so-lets-kilab70.bsky.social and Jason vevea @St Jude. Look out for two cool fluorescent ligands.
- 🧵Prepint alert! Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling | tinyurl.com/3n55hvsc. With Jason Vevea, Ed Chapman, and @so-lets-kilab70.bsky.social, we combined dye chemistry, HaloTag, microscopy and cell biology to make protein purification and manipulation tools.
- Reposted by David SoleckiCool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
- #ThoughtfulThursday Why does my AVATAR outside the lab have MORE GREY HAIR than real-life me? 😳 Is it: ✅ The avatar actually wrote ALL th3 grants? ✅ It’s aging in DOG YEARS from reviewer feedback? ✅ Or is it secretly running experiments at 3 AM? What’s your theory?👇 #ScienceLife #LabHumor
- Someone fixed my “Dorian Gray” avatar lol #sharpie
- Y’all microscopy nerds will understand my evening’s drink….its a StayGold
- 🚨 GOVERNMENT SHUTDOWN? NO PROBLEM! 🇺🇸 Petroglyph National Monument is WIDE OPEN & the ancient trials are CALLING! 🔥 Epic fall vibes leg flexing in the desert 💪 #LandofEnchantment #Petroglyph #NewMexico #Hiking
- ZOINKS! 🐕💨 The lab just unmasked the real ghost haunting our data... it was LIAM all along! 👻🔬 Repost if this Mystery Machine rolls harder than your feed! 🚐🎃 #Halloween #FluorescenceFriday #Halloween2025 #ScoobyDoo
- When chemistry meets neurons! Game-changing paper on multifunctional fluorescent ligands. Luke and Pratik built the nerdy toys; we got to play! Jason Vevea nailed biotin-HTL for mito magic. My lab rocked the JQ1 HTL to shuffle chromatin in mins. 1st collab win for our Neuronal Cell Biology Division.
- A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
- 🤯 Wait, BRD4 just got “dragged” into nucleoli by JQ1-HTL in under an hour?! This is one of the most crazy aspects of this paper…..condensate sorcery. Mind blown. 🔥
- Reposted by David SoleckiA new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
- Kirby Campbell just dropped a mind-blowing presentation at #KIDS25! Using cutting-edge FIB-SEM & super-resolution datasets, he’s unveiled how neurons condense chromatin. AI + data science reveal new “flavors” of heterochromatin. Shoutout to the Abbas Shirinifard and NIAL #microscopymonday
- Forget #MicroscopyMonday or #FluorescenceFriday — it’s #TrailblazingTuesday! The lab’s latest flex: a live-cell imaging probe catching Ser2-phosphorylated RNA Pol II CTD in real time Watch transcriptional elongation light up living nuclei! What’s the coolest thing you’ve seen under a microscope?
- 18 YEARS AGO, I kicked off a wild chase after the brain's biggest secrets, like it owed its blueprint to how it builds itself from scratch 🧠 Me + my fearless lab family turned curiosity into a powerhouse, probing frontiers. Shoutout to the St. Jude's vibe fueling breakthroughs over copycat science.
- 🚨 Mind-blowing Brain Club alert! Liam Hallada just dropped a 🔥 stellar talk that hits pause on your brain mid-thought. He transformed heavy tech lifts into pure gold: revolutionary new imaging pipelines, bold fresh questions, and razor-sharp methods to decode how neurons wire up #scicomm #CellBio
- Reposted by David SoleckiHalfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones. If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
- #HappyFluorescenceFriday! #microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications! Learn more & sign up: buff.ly/esGIotD
- Reposted by David SoleckiField notes from a weekend PI at the #microscope: vesicle cargo lanes lighting up in real time like @FedEx. This is the ML1N PX domain in a fibroblast. Hot damn, there’s mind-blowing action under the surface of cells: this video shows 2 min of time 🤯 #Cellbio #MicroscopyMonday #SciArt #SciComm
