ivanraimondi
- Sharper footprints, cleaner insights? Yuxuan Lin at the University of Pennsylvania explores a new approach that corrects Tn5 bias for bulk & single-cell ATAC-seq, boosting the accuracy of transcription-factor binding 🔬 👉 www.biorxiv.org/content/10.1... #SingleCell #Epigenomics #ATACseq
- 🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.
- 🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
- 🧬 Why D&D-seq? Existing methods struggle to profile weak/transient DNA:Protein interactions in single cells. We engineered a cutting-edge approach combining nanobody-tethered cytosine base editing to fill this gap. #SingleCell #Innovation
- 🧬 By coupling D&D-seq with 10xGenomics scATAC assay, we were able to map transcription factor binding event in single cells. 🔬✨ D&D-seq achieves precise single-cell Protein:DNA profiling!
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View full thread🙏 A huge thank you to the incredible team behind this work—your dedication and brilliance made this possible! Special thanks @landau.bsky.social to for the opportunity to work in such an inspiring environment @nygenome.org @WeillCornell.
