Brian Clark
Assist. Prof - WashU - Ophthalmology. Dev biologist studying regulation of retinal cell fate specification - Epigenetics and non-coding RNAs
- Reposted by Brian Clark[Not loaded yet]
- Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
- TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
- Identifying genome-wide locations of active DNA demethylation. Studies were performed in an ongoing, fruitful collaboration with John R Edwards and Alaina Urman, helping us integrate the new methylation profiling with previous studies from the Dyer and Nathans labs.
- Reposted by Brian ClarkWell, the Biology and Development of the Eye (BDE) study section has been postponed (previously scheduled for Thurs/Fri). I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.
