Zachary Compton
at the intersection of evolutionary theory and cancer biology
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- Reposted by Zachary ComptonEnjoyed this @natrevcancer.nature.com article on comparative oncology - how we can learn from other species 🐘🐋🦜🐍 about ways to prevent (& possibly treat) cancer. Both a review and a call to action for the research community. www.nature.com/articles/s41... @atjcagan.bsky.social @cmaley.bsky.social
- Just a few days left to apply for the Fall 2025 cohort of the Arizona Cancer Evolution Center Scholars program. Great training in comparative oncology, cancer evolution, and science communication! Open to all, not just Arizona State students.
- Our reply to Butler et al's recent @pnas.org paper on Peto's Paradox. www.pnas.org/doi/10.1073/...
- And their reply to our reply. I enjoyed their title. I propose that all future papers referring to Peto's Paradox must have a title playing on the word "paradoxical" www.pnas.org/doi/10.1073/...
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- Is cancer suppression in and of itself an adaptation? The full version of our The Elephant & the Spandrel is now online. academic.oup.com/emph/article...
- Reposted by Zachary ComptonBeata Ujvari, Andriy Marusyk and Aurora Nedelcu are organising a symposium on “Cancer in an evolutionary framework: across species and within individuals” at the @eseb2025.bsky.social conference in Barcelona this August. Abstact submission closes on Friday: eseb2025.com/call-for-abs...
- Reposted by Zachary ComptonChasing Perfection - previous work to optimize adaptive therapy schedules for cancer rely on monitoring the patient continuously. We find that accounting for discrete clinical appointments across multiple tumor models motivates patient-specific personalization in optimal tx! doi.org/10.1101/2025...
- Great interviews with so many awesome collaborators. One takeaway that is relevant given recent studies: Even if larger animals do in fact get more cancer, it does not falsify Peto’s Paradox. Large animals do not get orders of magnitude more cancer. www.the-scientist.com/peto-s-parad...
- Reposted by Zachary ComptonNew study on diet, plasma glucose, and cancer prevalence across vertebrates published in Nature communications (@naturecomms.bsky.social) www.nature.com/articles/s41...
- One more day to submit abstracts for ISEMPH talks! I am looking forward to hosting a symposium "The Future of Comparative Oncology" that will be paired with @evo-eco-onco.bsky.social's cancer evolution session.
- Reading Liam Revell & Luke Harmon's books on comparative phylogenetics, our team knew there would be important applications to comparative oncology --and the broader evolutionary medicine field. We explore these applications in our new preprint: www.biorxiv.org/content/10.1...
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- Walker Mellon getting ready to discuss some of the new comparative oncology projects we are focusing on this year! #SACB2025
- Reposted by Zachary ComptonThank you all for the suggestions, I compiled them all here for the time being (might try to make something more stable than a google doc later), in case it is useful for anyone else: docs.google.com/document/d/1... In the meantime, I will keep editing with new resources and recommendations!
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- Reposted by Zachary ComptonThe January issue of Cancer Discovery is now online! The cover features "Cancer Prevalance across Vertebrates" by @zacharytcompton.bsky.social and colleagues - read that and much more: aacrjournals.org/cancerdiscov...
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- @metzgerm.bsky.social wrote a wonderful Spotlight piece that accompanies the publication of our Cancer Discovery cover this morning. He highlights that our work opens as many exciting questions as it attempts to answer. aacrjournals.org/cancerdiscov...
- Next week I kick off the semester of Cancer Prevention & Control seminars! I will recap findings from our recent Cancer Discovery publication and focus on the exciting future research that needs to be done in comparative oncology
