Francoise Helmbacher
Developmental Biologist, #CNRS researcher, studying morphogenesis, muscle regeneration and pathologies, and curious for all life sciences.
Lab website: helmbacherlab.org
- Reposted by Francoise HelmbacherTumours aren’t just a messy mix of cells—they’re highly organised and hierarchical societies! Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. 🧵👇
- Reposted by Francoise Helmbacher#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.
- Reposted by Francoise HelmbacherNow live, and thanks to @erictopol.bsky.social for organising this!
- Reposted by Francoise Helmbacher📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
- Reposted by Francoise HelmbacherHuge congrats to the team of project "PatCorg" for the prestigious ERC Synergy grant dedicated to studying organoids to uncover mechanisms underlying cortical development: A Pierani (@ipnp.bsky.social), S Nedelec (Institut Monod), S Descroix and B Sorre (Institut Curie), and A Baffet (Inst Curie).
- Reposted by Francoise HelmbacherDan Perez founded the #FSHD Society to foster research & help patients w this painful & debilitating muscular dystrophy. It was a privilege to have known this brave, caring, smart person who was instrumental in getting research money for FSHD, a strange epigenetics-related disease. Melanie Ehrlich
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- Reposted by Francoise HelmbacherHow do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
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- Reposted by Francoise HelmbacherSo sad to hear the news - John truly was an inspiration to so many, and one of a kind. www.cam.ac.uk/research/new...
- Establishment of a mouse hepatocellular carcinoma tumoroid panel recapitulating inter- and intra- heterogeneity for disease modelling and combinatorial drug discovery biosignaling.biomedcentral.com/articles/10.... another big milestone from the Maina lab @crcm.bsky.social ! Contratulations!
- Reposted by Francoise HelmbacherVentricle position can be remodeled after heart looping! In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers. So grateful to all the authors for their expertise and input during this long (but fun) ride 💪 Read more here ⬇️
- New publication | Science Advances www.science.org/doi/10.1126/...
- Reposted by Francoise Helmbacher✨ Post-doc opportunity in axon biology, funded by #ATIP-Avenir! 👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches. Apply at: emploi.cnrs.fr/Offres/CDD/U... Thank you for sharing! 👋 🙏
- Reposted by Francoise HelmbacherThrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"! We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost. www.cell.com/iscience/ful...
- DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophy skeletalmusclejournal.biomedcentral.com/articles/10.... #FSHD, #DUX4, #Myoblue #SkeletalMuscle
- The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active www.nature.com/articles/s41... Fantastic new paper from Flavio Maina, Celia Sequera, Margherita Grattarola and colleagues at the @crcm.bsky.social #CancerResearch, #CRCM, #LiverCancer
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- Reposted by Francoise HelmbacherKicking off the lab BlueSky with this picture of a happy hairy growing #axon! Looking forward to connecting with science chats and to growing research ideas 🧠🔬✨
- Reposted by Francoise HelmbacherSARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...
- Reposted by Francoise Helmbacher🚨 PLF : Les préconisations de l’IGF/IGESR menacent directement notre santé et celle de nos enfants ! 📣 Les principales fondations et associations de recherche biomédicale expriment leur profonde inquiétude bit.ly/44u3aSR
- Reposted by Francoise HelmbacherPostdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
- Reposted by Francoise HelmbacherTextbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22
- Reposted by Francoise HelmbacherThe amazing organization team of #ShapingLife3 meeting of @sfbd.bsky.social in sunny Cassis! Thanks to the great scientists for sharing their passion for embryos, and the beauty of life ! @maitrejl.bsky.social @cedricmaurange.bsky.social @maevalux.bsky.social @ibdm.bsky.social and others
- The tumor suppressor FAT1 controls YAP/TAZ protein degradation and tumor cell proliferation through E3 ligase MIB2 journals.plos.org/plosone/arti... This work from Rui Li, Stefan Offermanns, and colleagues, extends the role of this FAT1-MIB2-YAP axis to the control of tumour growth
- Reposted by Francoise HelmbacherDo you want to join us to work in neurodevelopmental biology? Please apply 👇 #SEBD
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- Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits www.biorxiv.org/content/10.1... Beautiful new preprint from the Tschopp lab
- Reposted by Francoise HelmbacherVery excited to share our latest work revealing a prominent role for LADs in commisioning cell fates in mouse organ & tissue development, particularly of the limb. Amazing work by Isabel and Samy together with @stemundi.bsky.social & @drmrobson.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Francoise HelmbacherIn the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors. 🧠📈
- Reposted by Francoise HelmbacherOne thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
- Reposted by Francoise HelmbacherCheck out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!
- New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium. 🧠🔧 Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt... Explore the full issue here: www.cell.com/neuron/current
- Congrats @frankschnorrer.bsky.social and all involved ! Beautiful work ! 👏🎉
- Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social www.science.org/doi/epdf/10....
- Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression. New preprint from Helen McNeill and colleagues doi.org/10.1101/2025...
- Reposted by Francoise HelmbacherNew lab paper out! 😀 We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
- Reposted by Francoise HelmbacherCongrats to @columbiauniversity.bsky.social scientists Gary Struhl & Iva Greenwald for winning the @gairdnerawards.bsky.social Award for their research yielding critical insights on how cells communicate with their neighbors during development. Read: zuckermaninstitute.columbia.edu/columbia-gai...
- Reposted by Francoise Helmbacher🚨 Save the date 🚨 🧬 Shaping Life 3 is back! 📆 Join us June 3-6, 2025, in Cassis, France, for cutting-edge talks on stem cells, morphogenesis, gene regulation & more! 🌊 Organized by @sfbd.bsky.social & IBDM at the stunning Oustau Calendal. More info 👇
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- Reposted by Francoise HelmbacherIf you’re curious about why lymphatic endothelial cells have their jigsaw puzzle-like shape, check out our paper @Nature rdcu.be/eejhZ
- Reposted by Francoise HelmbacherExcited to share that the preprint of my Ph.D. work is now available! 🎉 Huge thanks to my amazing co-authors for their support and collaboration: @gaellel.bsky.social, H. Varet, V. Laville, J. Fernandes, @tajbakhshlab.bsky.social, @brendan-evano.bsky.social. @devstempasteur.bsky.social @pasteur.fr
- Reposted by Francoise HelmbacherDo not miss this great opportunity to present your work to the Neuroscience community in a stimulating and friendly environment 🤗 We are looking forward to welcome you in our beautiful and vibrant city of #Montpellier! See you soon @socneuro.bsky.social @fens.org @inserm.fr @cnrs.fr
- 🔴 New deadline! You have until March 27 included to submit an abstract for a poster presentation at #NeuroFrance2025 Don't miss this great opportunity to present your research to a broad multidisciplinary audience Registration & abstract submission: www.neurosciences.asso.fr/SN25/
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- Reposted by Francoise HelmbacherExcited to share today, a whole new chapter in my scientific journey. TAPELab( @christophertape.bsky.social) latest review on ‘High-dimensional signalling analysis of organoids’ is now online. Full review available here: www.sciencedirect.com/science/arti...
- Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reporters www.biorxiv.org/content/10.1... Fantastic preprint from Joriene de Nooij and colleagues
- Reposted by Francoise HelmbacherPlease repost - some places available for students who desire to learn all about stem cells, and then some, in a great environment with leading experts in the respective fields.
- Reposted by Francoise HelmbacherSpatial transcriptomics in fly brain and body. Wonderful collaboration with @steinaerts.bsky.social led by @jasperjanssens.bsky.social @pierremangeol.bsky.social Nikolai Hecker & Gabriele Partel - look at mRNA patterns in muscles and brains spatialfly.aertslab.org elifesciences.org/reviewed-pre...
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- Another amazing milestone from Flavio Maina & Colleagues Floriane Cannet and Celia Sequera et al. 🎉👏 ! Tracing specificity of immune landscape remodelling associated with distinct anticancer treatments: iScience www.cell.com/iscience/ful... @crcm.bsky.social @borgjp.bsky.social
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- Reposted by Francoise HelmbacherDelighted to showcase our atlas for the inference of ligand-receptor mediated interactions between neuronal subtypes during mouse cortex development. Herculean endeavor by former PhD student Rémi Mathieu (now @alleninstitute.bsky.social) and team, in collaboration with @LudovicTelley Thread 🧵
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- New review on FAPs by @jyotijaiswal.bsky.social and colleagues Exploring the therapeutic potential of fibroadipogenic progenitors in muscle disease journals.sagepub.com/doi/full/10....
- New review on FAPs by @jyotijaiswal.bsky.social and colleagues Exploring the therapeutic potential of fibroadipogenic progenitors in muscle disease journals.sagepub.com/doi/full/10....
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- Reposted by Francoise HelmbacherWe are looking for a new Executive Editor on the journal, with @katherine-brown.bsky.social taking on a new role at @biologists.bsky.social. If you're an experienced editor with a love of developmental biology and its community, this could be the job for you. Full details in the link below.
- Reposted by Francoise HelmbacherAnd I am still looking for a technician... help!! #MyoBlue
- Reposted by Francoise HelmbacherCongrats to #StainierLab and colleagues for this interesting new @Nature manuscript: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. #DMD #MyoBlue tinyurl.com/4ky93z67
