Xiaotian Liao
PhD student @sangerinstitute
- Reposted by Xiaotian Liao🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.
- Reposted by Xiaotian LiaoOur paper on myxozoan genomes is out now in G3! See thread below for a brief recap (slight change of title from the preprint, same content). Thank you also to @arunsethuraman.bsky.social for handling the manuscript and @joannamasel.bsky.social for helpful comments. academic.oup.com/g3journal/ad...
- Myxozoans are tiny parasitic animals whose closest free-living relatives are jellyfish. They also haven't been extensively sequenced. However, we were lucky enough to spot some sequences in data from infected fish. After some experimenting, we got two new genomes: www.biorxiv.org/content/10.1...
- Reposted by Xiaotian LiaoProud to have authored this review with brilliant people. Hope we inspire more attempts to sequence the #protist genomes that are within reach! Huge thanks to Alexandra Schoenle for leading. #ProtistsOnSky authors.elsevier.com/sd/article/S...
- Reposted by Xiaotian LiaoThe evolution of allostery in a protein family. Aina's new preprint containing seven complete comparative allosteric maps biorxiv.org/content/10.1...
- Reposted by Xiaotian LiaoNew preprint: Allostery is a widespread cause of loss-of-function variant pathogenicity by the great @xt117.bsky.social biorxiv.org/content/10.1...
- Reposted by Xiaotian LiaoAlzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 www.science.org/doi/10.1126/...
- Reposted by Xiaotian Liao1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules. www.biorxiv.org/content/10.1... With @benlehner.bsky.social [1/7]
- Reposted by Xiaotian LiaoGPCR-MAPS is now live! www.biorxiv.org/content/10.1... A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social
