Cathryn Lewis
Genetics - Statistics - Psychiatry.
Depression pharmacogenetics.
SGDP Centre, King’s College London. Psychiatric Genomics Consortium.
- Reposted by Cathryn LewisIn today’s article, @kingsioppn.bsky.social Professor Cathryn Lewis @cathrynlewis.bsky.social discusses current evidence on the efficacy of #antidepressants and how research should move forward to support #precisionmedicine approaches in #mentalhealth. www.inspirethemind.org/post/underst...
- Autumns has arrived - the @kingsioppn.bsky.social campuses are buzzing with new students but still sunny and mild enough for an early morning coffee outside at Ortus.
- If your Monday morning is challenging, this post is a reminder of positive changes over the last 10 years. From cancer treatment to music access to dresses-with-pockets Hang in there amid the turmoil.
- 🚨Come work with us!🚨 Open post for Clinical Psychology Lecturer, combining NHS clinical work with research and education at the SGDP Centre.
- Delighted to be hiring a new Clinical Psychology Lecturer to come and join our vibrant environment at the SGDP Centre @kingsioppn.bsky.social @kingscollegelondon.bsky.social please share! my.corehr.com/pls/coreport...
- Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social 🔗 Paper: lnkd.in/evJ9daBF 🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ www.linkedin.com/posts/oliver...
- Reposted by Cathryn LewisWe're back, with a fresh new lineup of talks and workshops! Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud! This event is free and open to all: tinyurl.com/3ewaduvm
- Reposted by Cathryn Lewis🎉(1/4) Excited to share that our latest paper is now published! We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP. www.nature.com/articles/s41...
- This morning's email had *four* paper review requests - again. Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers. Suggestions for short-term fixes to help this broken system? #academia #publishing
- At @edinburghup.bsky.social University for two day AMBER team meeting. @wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
- Reposted by Cathryn Lewis(1/2) Only one-third of people taking antidepressants for depression respond to the first drug they are prescribed and we know little about WHICH drug will work for each patient.
- Reposted by Cathryn LewisWomen make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM We want to change it, through targeted editorial policies & outreach. But change will take everyone! 🧪 www.nature.com/articles/d41...
- Reposted by Cathryn Lewis"This work is a first step in using health records to define and predict SSRI drug responses." - Professor Cathryn Lewis @cathrynlewis.bsky.social is Deputy Lead of our Trials, Genomics and Prediction theme, and the research was supported by @nihr.bsky.social and @wellcometrust.bsky.social 👇
- Who benefits from antidepressants? New research from IoPPN ( @cathrynlewis.bsky.social) and University of Edinburgh shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others www.kcl.ac.uk/news/who-ben...
- Our new paper assessing switching between antidepressants as a measure of non-response is now out in BPGOS. Genetic studies show prediction from polygenic scores of remission from clinical studies. Paper: www.sciencedirect.com/science/arti... @kingsioppn.bsky.social Webstory ⬇️
- Who benefits from antidepressants? New research from IoPPN ( @cathrynlewis.bsky.social) and University of Edinburgh shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others www.kcl.ac.uk/news/who-ben...
- Congratulations to Lachlan Gilchrist for his successful #PhD viva on Friday. He even admitted to enjoying the discussion! Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social. @kingsioppn.bsky.social
- The SGDP Centre Atrium bookshare captures so much of our work culture. From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas. Books in English, Chinese, French. Suggested donations supporting local charity. All welcome to donate & borrow, @kingsioppn.bsky.social
- #IoPPNFestival Fran Denk @denklab.bsky.social, winner of @kingsioppn.bsky.social Dean’s award for Research Integrity highlighting the importance of statistical understanding and application to support good research practices - honest, rigorous, open, respectful. #statistics rocks!
- Reposted by Cathryn LewisThe #IoPPNResearchFest is here! Join us for rapid-fire talks by IoPPN staff on the latest research in psychiatry, psychology + neuroscience, from the power of belief, neurotrauma and more. Follow us and @thementalelf.bsky.social for highlights and key messages. #AcademiaSky
- #BNA2025 Great addition to a conference- a Reading Room - with a view. Thanks to The Queen’s Reading Room for funding and interesting sessions on reading + neuroscience
- #BNA2025 Ekta Patel from the Psychiatry Consortium, part of @md-catapult.bsky.social launches our Academia - Industry symposium. Strengthening collaborations through grand challenges, target validation and engagement
- Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
- 📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social #depression #statistics #genetics #pharmacogenetics #antidepressants my.corehr.com/pls/coreport...
- Reposted by Cathryn Lewis(1/1) 🧠🌎 Just published in Nature Genetics: “Psychiatric genetics in the diverse landscape of Latin American populations” A comprehensive review of progress, challenges, and future directions. 🔗 www.nature.com/articles/s41... #PsychiatricGenetics #GlobalGenomics
- 📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social #depression #statistics #genetics #pharmacogenetics #antidepressants my.corehr.com/pls/coreport...
- Reposted by Cathryn LewisJoin us for the ISPG Members' Meetup on March 26th! Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline. Don't miss out: us06web.zoom.us/meeting/regi... #ISPG #Genetics #PolygenicScores #Bioinformatics
- Paper published: first output from our Wellcome Trust Mental Health Award, AMBER, on how UK Biobank participants report on whether antidepressants helped their depression. tl;dr 75% said SSRI antidepressants helped them feel better ➡️ Paper in Psychological Medicine bit.ly/4ifjcWC 🧵
- Thanks to all co-authors - Michelle Kamp, Chris Lo, @alex-gillett.bsky.social @mcintosh2001.bsky.social @oliverpain.bsky.social & all - Funder, @wellcometrust.bsky.social - @ukbiobank.bsky.social participants and - @kingsioppn.bsky.social 2/n
- 75% of UK Biobank participants said "Yes" antidepressants helped them feel better Likely reflecting a reduction in depression symptoms and improved day-to-day functioning, offering a broader perspective on treatment impact beyond clinical remission 3/n
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View full threadAntidepressants are widely prescribed - Potential for more personalised prescribing - Building on clinical and patient perspectives for more effective treatment. - Stronger research base needed Paper covered in @theipaper.com inews.co.uk/news/health/... 8/end
- Reposted by Cathryn LewisThree quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research. Read more➡️ www.kcl.ac.uk/news/three-q... #SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social
- Reposted by Cathryn LewisThe Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues: github.com/Ripkelab/ric... Any feedback is highly welcome! @pgcgenetics.bsky.social
- Reposted by Cathryn LewisIn 2016, TV reporter James Longman met with IoPPN researchers Profs @cathrynlewis.bsky.social & Roland Zahn on BBC Two to understand how #depression can run in families. His new memoir #TheInheritedMind documents his personal investigation into mental illness. www.theguardian.com/books/2025/f...
- Reposted by Cathryn LewisNEW research by IoPPN (@cathrynlewis.bsky.social) and @edinburghuni.bsky.social (Andrew McIntosh) researchers have identified new genetic risk factors for #depression across all global populations for the 1st time, in study in Cell Read more: www.kcl.ac.uk/news/global-...
- To start 2025 on a cheerful note, the SGDP Centre, @kingsioppn.bsky.social are 'dopamine dressing'. Today - 🟥red, 16th Jan -🟦blue, 23rd Jan - 🟩green, 30th Jan - 🏳️🌈any bright colour. Even socks count!
- Dopamine dressing is from the fashion industry "bright colours brighten mood" Weak scientific support (0 pubmed articles). Placebo effect: people talk to each other more, and smile as they walk into a colourful seminar or meeting. Works online, too 💚
- Reposted by Cathryn LewisNew research (Julian Mutz, Raquel Iniesta, @cathrynlewis.bsky.social) has evaluated AI-based metabolomic 'ageing clocks', which predict health and lifespan using data from blood. It was published in Science Advances, with support of the @nihrmaudsleybrc.bsky.social www.kcl.ac.uk/news/researc...
