Intensive Care Medicine Journal
Intensive Care Medicine serves as the premier publication platform facilitating the communication and exchange of cutting-edge research and ideas within the field of intensive care medicine on a comprehensive scale. This platform is designed for profession
- Acute kidney injury biomarkers can increase diagnostic granularity, refine risk and support a more personalised approach to acute kidney injury. zurl.co/Q3k9z
- Canadian RECOVER participants showed higher ICU mortality in males, while female ICU survivors had lower functional independence and more frequent and severe depression over 1-year follow-up. zurl.co/UGuZp
- Potential organ donors outside intensive care create a further ethical challenge when ICU transfer is pursued mainly to enable planned circulatory-death donation. zurl.co/Tn4tp
- #VisualAbstract An international Delphi consensus standardised definition, sampling, treatment and prevention of peripheral ECMO cannula-site infection, including suspicion criteria and dressing recommendations. zurl.co/cgb5n
- Perioperative ECMO supports selected cardiac, lung transplant, airway and organ donation care. zurl.co/WhU0z
- The authors call for nuanced guidance on extracorporeal blood purification in severe pharmaceutical poisoning. zurl.co/eOgnM
- Intraoperative ventilation should be tailored to minimise lung injury and postoperative pulmonary complications. zurl.co/3BMgl
- #VisualAbstract Daily family-completed FAM-CAM delirium screening increased ICU caregiver satisfaction in English and Spanish speakers, with higher overall FS-ICU-24 scores than controls and mitigation of lower scores linked to delirium. zurl.co/USs6X
- Sepsis-induced DIC in septic shock showed impaired fibrinolysis with reduced plasmin generation despite elevated D-dimer. zurl.co/Zliks
- In sepsis, about three-quarters of crystalloid volume moves into the interstitial space, and a positive fluid balance may independently predict mortality. zurl.co/QkQN6
- Survey respondents reported positive experience and educational value for a large-scale online simulation programme in mechanical ventilation. zurl.co/cspF2
- #VisualAbstract In the Cis-A-Rein multicentre double-blind randomised trial, cyclosporine pretreatment of brain-dead kidney donors did not significantly reduce delayed graft function after transplantation. zurl.co/4BqvX
- Professional negotiation techniques are adapted for ICU family meetings to reduce conflict and support patient-centred decision-making. zurl.co/uE2yl
- Higher time-varying dynamic driving pressure during the first 14 ICU days was associated with increased mortality in mechanically ventilated adults with acute brain injury. zurl.co/y8PKq
- Rapid ICU workforce upskilling through C19_SPACE demonstrated cost-effective expansion of safely staffed ICU capacity during the COVID-19 crisis. zurl.co/pCEZt
- #ICM-Quizz #MedEd CT showed umbilical herniation of the gastric antrum and duodenum with vomiting-related metabolic alkalosis, hypochloremia and hypokalemia. NG decompression and IV saline with potassium corrected these before repair. zurl.co/7DFnU
- In 839 mechanically ventilated acute brain injury patients, spontaneous breathing trial mode and duration were not associated with extubation failure. zurl.co/kICes
- Mechanical ventilation may alter lived breathing experience and self, supporting a more ethically respectful approach to patient care. zurl.co/h5qNe
- #VisualAbstract Older adults have accounted for more than half of ICU patient-days for the past 25 years. Frailty, disability in functional activities and multimorbidity are more strongly associated with ICU and post-ICU outcomes than chronological age. zurl.co/rzjjW
- GERDA integrates ICU procurement, admission days and environmental data to track product use per patient day and associated CO₂, land and water impacts. zurl.co/LAnDp
- Severe community-acquired pneumonia remains high-risk in ICU care, with early risk screening, prompt pathogen-appropriate antibiotics, rapid de-escalation and tailored supportive care central to management. zurl.co/KqoSM
- Fulminant myocarditis requiring temporary mechanical support carried 36% mortality at 1 year. zurl.co/FGZAD
- #VisualAbstract ARDS care centres on early recognition, lung-protective ventilation with individualised PEEP and prone positioning, with close monitoring and selective use of non-invasive supports, neuromuscular blockade, steroids and conservative fluids. zurl.co/vyrez
- Daily family-completed FAM-CAM delirium screening increased ICU caregiver satisfaction in English and Spanish speakers, with higher overall FS-ICU-24 scores than controls and mitigation of lower scores linked to delirium. zurl.co/G76bI
- Intensive care staff play a decisive gatekeeping role in controlled donation after circulatory death, shaping consent, processes, and ethical integrity across end-of-life care. zurl.co/5i26O
- Diagnostic uncertainty in ICU pneumonia persists, as infectious and non-infectious conditions overlap and no single test reliably resolves complexity in management decisions. zurl.co/qTZey
- #VisualAbstract Randomised cross-over trial in CVVH with regional citrate anticoagulation: low-bicarbonate replacement fluid reduced pH and bicarbonate excursions vs high-bicarbonate, with similar pH normalisation in acidotic patients. zurl.co/k36jW
- The alveolar gas equation estimates PAO2 and, with the A–a gradient, helps distinguish ventilation problems from impaired gas exchange in hypoxemia. zurl.co/N3auG
- An international Delphi consensus standardised definition, sampling, treatment and prevention of peripheral ECMO cannula-site infection, including suspicion criteria and dressing recommendations, and excluding routine antibiotic prophylaxis. zurl.co/Xhxr9
- Positive end-expiratory pressure influences recruitment, airway patency, haemodynamics and organ perfusion beyond oxygenation. zurl.co/cIQtq
- #ICM-Quizz #MedEd Septic shock due to Streptobacillus moniliformis rat-bite fever with spondylodiscitis and epiduritis. Diagnosis from anaerobic blood cultures and 16S rRNA PCR underlines socioeconomic exposure and the need for rapid, targeted antimicrobials. zurl.co/ietiG
- #ICM-Quizz #MedEd A 59-year-old homeless man presented with septic shock and extensive C3–C4 and L5–S1 spondylodiscitis. Anaerobic blood cultures turned positive after 70 hours and TEE showed aortic valve thickening. What's your diagnosis?
- Bedside PEEP titration in spontaneously breathing ARDS was compared across 12 variables during a decremental PEEP trial in 30 intubated patients, highlighting overdistension–collapse and end-expiratory transpulmonary pressure as most PEEP-sensitive. zurl.co/PX92b
- A first national UK effort standardises management of cardiocirculatory emergencies in adult patients supported with ECMO using a simplified ALS-style pathway. zurl.co/Zf2t8
- European Medicines Agency guidance advises avoiding polyacrylonitrile membranes for continuous kidney replacement therapy during caspofungin treatment, following reports of membrane adsorption despite negligible clearance by diffusion or convection. zurl.co/mXDzS
- #VisualAbstract Biomarker-based immune profiles in sepsis show frequent reclassification within hours, challenging the reliability of discrete endotypes for targeted treatment. zurl.co/v2eqr
- A multinational survey of 256 clinicians found heterogeneous practices for monitoring respiratory effort during invasive mechanical ventilation. zurl.co/faLwn
- Critical appraisal of observational studies depends on assessing confounding, mediation, collider bias, missing data, overfitting, model assumptions and generalisability. zurl.co/Sp5PO
- In the Cis-A-Rein multicentre double-blind randomised trial, cyclosporine pretreatment of brain-dead kidney donors did not significantly reduce delayed graft function after transplantation. zurl.co/wR9hK
- #VisualAbstract In French ICUs, use of renal replacement therapy for acute kidney injury declined over 12 years, while overall ICU mortality fell and practice shifted from intermittent to continuous modalities. zurl.co/wJcyJ
- Major bleeding in critical care has a reported incidence of 5% to over 50% and is linked to high morbidity and mortality. zurl.co/aikW7
- Care for very old critically ill patients spans pre-ICU assessment through long-term follow-up, with priority on quality of life and independence after discharge. zurl.co/gVGAt
- #VisualAbstract Thoracic ultrasound improves diagnostic accuracy in shock and acute respiratory failure, helping identify hemodynamic profiles and respiratory conditions while supporting rapid bedside decisions. zurl.co/cdgQ5
- Recent data suggest immunocompromised ICU patients are not at higher overall risk of ICU-acquired infections or multidrug-resistant bacteria, but remain prone to opportunistic viral and fungal infections. zurl.co/QKo1C
- An ICU sustainability bundle was associated with lower per-patient-day resource consumption for medication and medical devices and a 14% reduction in costs. zurl.co/6ScdC
- Global efforts to standardize undergraduate ICU education and curricula are needed, and planetary health, mitigation and adaptation to the environmental crisis should be introduced earlier in training, well before residency. zurl.co/PMYcK
- #VisualAbstract Machine-learning analysis of the TEAM trial identified varying individual responses to enhanced early mobilisation, showing potential benefit for some ICU patients and possible harm for others based on baseline characteristics. zurl.co/2i5XG
- An international ESICM-endorsed survey of 303 responses found wide variation in veno-venous ECMO weaning, with readiness and sweep gas-off success judged mainly by arterial gas exchange and pH. zurl.co/OrKoe
- In PEEP-PIC data, similar PEEP increases were linked to smaller ICP rises in traumatic brain injury than in non-traumatic acute brain injury. zurl.co/sdS1h
