Farshid Guilak
@ShrinersStLouis @wustlortho @washubme @washudevbio @wustlCRM @theNAMedicine @theNAEng @AcadofInventors @cytexortho @MyAOCConnect #racquetball
- Sleep matters for joint health! In our new paper led by Dr Liz Rowlands, we studied sleep habits of 500,000 people. Osteoarthritis risk was highest with <6 hours of nightly sleep and significantly increased by shift work. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Farshid GuilakHonored to share our new paper, Osteoarthritis as a Systemic Disease, in @natrevrheum.nature.com, out today: rdcu.be/eSXLW - thanks to Ida Haugen, @tuhinaneogi.bsky.social and @farsh-g.bsky.social for your input on gaps and opportunities.
- Reposted by Farshid Guilak[Not loaded yet]
- Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...
- Huge congrats to Dr. Amanda Cimino for an outstanding presentation and defense - her committee said it was time for a "PhD+" degree. Amazing work!
- Chronotherapy in Rheumatoid Arthritis Treatment: Tantalizing but Understudied www.medscape.com/viewarticle/...
- Reposted by Farshid Guilak[Not loaded yet]
- Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....
- Reposted by Farshid Guilak[Not loaded yet]
- Congrats to Amanda Cimino for her latest paper creating a chronogenetic gene circuit that automatically delivers anti-inflammatory biologic drugs in response to inflammation or circadian signal! jbioleng.biomedcentral.com/articles/10....
- Lots of celebrations this month in the Guilak Lab! Congrats to Xinyi Melissa Li and Katelyn Lipa for passing their qualifying exams with flying colors!
- Reposted by Farshid Guilak[Not loaded yet]
- Reposted by Farshid Guilak[Not loaded yet]
- Reposted by Farshid Guilak[Not loaded yet]
- Congrats to Sophie Paradi on a fantastic Master's thesis and defense! Amazing work and collaboration with Erica Ely and many others in the Guilak Lab
- Reposted by Farshid Guilak[Not loaded yet]
- Congrats @kelseyhcollins.bsky.social on another tour de force, shedding further light into the relationship between obesity and OA! The more we learn, the more complex it gets... Fantastic collaboration with the June lab and WashU Rheumatology!
- put me in, coach...
- Join us today for our AOC Thought Leaders Webinar: Managing the Research Enterprise — for anyone navigating the evolving landscape of academic orthopaedics. April 24 | 4:00 PM ET Register Here: lnkd.in/eTrzEem6 Joint the AOC at myaocconnect.com!
- Congrats Dr. Jackie Garcia on an amazing dissertation on defense "Characterizing PIEZO1 Mechanotransduction in Articular Chondrocytes"!
- Excited for our most recent publication mapping macrophage populations in the synovium with knee injury and obesity! Great work by @nharasymowicz.bsky.social and team!
- Reposted by Farshid Guilak[Not loaded yet]
- Engineered stem cells automatically deliver arthritis drugs at prescribed times of day apnews.com/press-releas... www.nature.com/articles/s41...
- We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body & automatically deliver biological drugs on a 24 hr cycle. www.nature.com/articles/s41...
- On #RareDiseaseDay, we are excited to publish Zainab Harissa's paper showing that rare, dysplasia-causing mutations in the ion channel TRPV4 alter the response of chondrocytes to mechanical loading. journals.physiology.org/doi/abs/10.1...
- Check out the latest insights on what controls pericellular matrix properties (measured by atomic force microscopy) as it is degraded in OA. fantastic collaboration with Marina Danalache. Congrats to Jule Nieuwstraten for leading this study!
- Congrats to all the new members of the National Academy of Engineering, especially our many biomedical engineering colleagues Kyriacos Athanasiou, Sam Achilefu, Lisa Brannon-Peppas, Lydia Kavraki, and many others! www.nae.edu/331605/NAENe...
- Reposted by Farshid Guilak[Not loaded yet]
