Jean-Charles Lambert
Team leader, neuroscientist specialized in genetics and post-genomics of Alzheimer’s disease. in EN or/ou en FR 🇫🇷🇪🇺🏳️🌈
- In this preprint, the main consortia working on Alzheimer GWAS combined their efforts to validate an detect new loci associated with AD risk. We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.
Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia medrxiv.org/content/10.1101/202…
- This indicates that assessing the sensitivity of results of GWAS (or GWAS secondary analyses, especially those based on genome-wide statistics) on clinically-diagnosed cases will become increasingly important as the proportion of proxy and biobank cases included in the GWAS increases.
- Reposted by Jean-Charles Lambert🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease” Join the network or DM for more info
- In this preprint led by Devrim Kilinc and Pierre Dourlen, we observed that differential expression of BIN1 isoforms in the presynaptic part leads to differential synaptotoxicity. BIN1 isoforms could contribute to the synaptic loss observed in Alzheimer's disease. www.biorxiv.org/content/10.1...
- In this preprint, primarily conducted by Dolores Siedlecki, we established a neuron-microglia co-culture model within the synaptic chamber of a microfluidic device. This compartmented approach enables us to study synapse phagocytosis in close proximity to microglia. www.biorxiv.org/content/10.1...
- Reposted by Jean-Charles LambertToday, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community. reeserichardson.blog/2025/08/04/a...
- In this new EADB preprint led by Ole Andreassen, we present an improved polygenic hazard score model for AD that demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models. www.medrxiv.org/content/10.1...
- Happy cat on my belly
- A new EADB paper published in Nature Communications and led by Kristel Van Steen, Cornelia Van Duijn and Valentina Escott-Price. We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer. www.nature.com/articles/s41...
- Reposted by Jean-Charles LambertFromFB: 😂
- Finally out in Nature genetics ! A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries. www.nature.com/articles/s41...
- This work would not have been possible without this global and strongly collaborative effort (particularly Richard Sherva and Mark Logue of the Million Veteran Programme in the US, and Yoontae Kim and Jungsoo Gim of the GARD study in South Korea).
- Our work produced several important findings: 1. The associations between a simple polygenic score (PGS) based on the European GWAS-defined loci and AD risk in European populations is slightly influenced by the APOE genotype, suggesting existence of independent genetic entities for sporadic AD
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View full thread5. The PGS/PRS associations mainly capture genetic information related to AD because they weakened as the diagnosis was broadened. The quality of the clinical diagnosis can interfere with the measurement of the association between the PGS/PRS and the AD risk in a given population.
- Reposted by Jean-Charles LambertTrump’s cuts to more than 1700 #NIH grants get court hearing www.science.org/content/arti... by @sarareardon.bsky.social @science.org #Alzheimers #dementia #neuroscience #science
- Reposted by Jean-Charles LambertThis is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.
- Reposted by Jean-Charles LambertAnnouncing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9
- Reposted by Jean-Charles LambertHere is a direct link to the open access article @amit-das.bsky.social mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.
- Reposted by Jean-Charles LambertI went in search of cygnets. Still not hatched so had to make do with a heron fishing instead. Look at those feet! #UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha
- Currently visiting the Medieval Museum in Barcelona. This was painted in 1210…
- In this report, to improve our understanding of the genetic architecture of AD in the context of its main genetic driver, the EADB consortium and collaborators performed the largest global genome-wide association studies stratified by ε4 and ε2 carrier status. www.medrxiv.org/content/10.1...
- And definitively accepted after more than a month of editing to meet all the publisher's requirements.
- Reposted by Jean-Charles Lambert'BIN1 and Alzheimer’s disease: the tau connection' by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social www.cell.com/trends/neuro...
- When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years. www.sciencedirect.com/science/arti...
- Reposted by Jean-Charles LambertQuick guide to understand your cat
- Reposted by Jean-Charles Lambertam pleased to share our letter, highlighting that the science does not yet support regulatory approval of amyloid-targeting therapies for AD based solely on biomarker evidence. alz-journals.onlinelibrary.wiley.com/doi/full/10....
- She's 8 years old and it sometimes seems like she still looks like a teenage cat. Admittedly, she's a very small size
- Reposted by Jean-Charles LambertJoin us at @pasteurlille.bsky.social ! We're hiring a Facility Manager specializing in human iPSCs, organoids, and organ-on-chip technologies. Drive innovation in cutting-edge biomedical research. Apply now! Contact Dr Alexandre Grassart #CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social
- Reposted by Jean-Charles Lambert📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣 Plus d'infos sur le mouvement 👉 standupforscience.fr #pasteurlille
- Reposted by Jean-Charles Lambert[This post could not be retrieved]
- Reposted by Jean-Charles LambertFrench Senator Claude Malhuret: "Washington has become Nero’s court, with an incendiary emperor, submissive courtiers and a jester high on ketamine... We were at war with a dictator, we are now at war with a dictator backed by a traitor."
- Il y a quelques temp, j’avais vu un message de @damienbarraudmd.bsky.social à propos de la serie “The Pitt”…J’ai commencé à la regarder. Je ne peux juger de sa veracité mais elle a quelque chose en plus je trouve … une vraie humanité et une certaine forme de simplicité (bon c’est quand même un show)
- Finally accepted “in principle” In Nature Genetics … 18 months of hard works because of massive revisions (that strongly improved the manuscript to be honest). A long journey finally successful. What a relief …
- Reposted by Jean-Charles LambertZelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.
- Dear American friends I'm not sure you realise what a disaster we have just witnessed today. The US is on Russia's side, and we have understood this once and for all A page has probably been turned between Europe and the USA It is a sad day
- Reposted by Jean-Charles Lambert1/ NEW: Lecanemab in France The French Federation of Memory Clinics just released its appropriate use recommendations for #Lecanemab in early #Alzheimers. What’s new? How does it compare to U.S. guidelines? A thread 🧵⬇️ www.sciencedirect.com/science/arti...
- Reposted by Jean-Charles LambertDaily reminder of who Musk is:
- Reposted by Jean-Charles LambertAlzheimer's research funding is in the DOGE crosshairs, putting invaluable datasets (including tens of thousands of genomes) and biorepositories at risk. This reflects the volunteer efforts of thousands of research participants over four decades. Please contact your reps/senators. Hands off NIH.
- Reposted by Jean-Charles LambertPortuguese editorial cartoonist Zez Vaz reaches back to Tiananmen Square to call on American defiance.
- Received today I'll read it with interest ... probably unfair to the vast majority of researchers who are doing their best to understand and cure Alzheimer's disease. A few black sheep mar the constant, relentless efforts of a community that is aware of what is at stake.
- Reposted by Jean-Charles LambertMy annual Valentine’s post of this image that happens to land on #FluorescenceFriday this year! An axon approaching a kidney glomerulus doing its best to look like a rose.
- Reposted by Jean-Charles LambertExciting news! Our paper on GWAS gene prioritization for Creutzfeldt-Jakob Disease is now published in Brain! 🧠🧬 @brain1878.bsky.social We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease. Check it out here: academic.oup.com/brain/advanc...
- It is my great pleasure to announce the launch of the European Alzheimer & Dementia Biobank website! This site has been designed to present our work, our organisation and to encourage collaborations. Do not hesitate to contact us! eadb.eu
- Reposted by Jean-Charles LambertVery happy to see our review on Alzheimer's disease rare genetic variants published in @natrevneurol.bsky.social! 🧠🧬 Huge congrats to our PhD student @laradedeyn.bsky.social 🎉👏✨ www.nature.com/articles/s41...
- Je ne pense pas que les deux points de vue soient antonymes. Ils ne décrivent pas les mêmes champs de discussions. La science et la démarche scientifique ont pour objectif d’établir une hypothèse puis une théorie pour expliquer des faits observés, mesurés, reproduits et donc établis.
- Dans ce sens, les faits scientifiques ne peuvent être des opinions. La terre est ronde, la gravité peut être transcrite en équations, la théorie de l’évolution est incroyablement puissante pour décrire le vivant, le SIDA est dû au virus HIV, les vaccins à ARNm sont des outils remarquables.
- Dans ce sens la science n’est pas politique, elle se suffit à elle-même dans la recherche de véracité pour décrire ce qui existe autour de nous. Je crois que c’est le sens du propos de @qffwffq en montrant que finalement la science peut aller au-delà des limites d’une société.
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View full threadDans son essence, la science se veut donc objective et impartiale, et c’est pourquoi une méthode est mise en place pour maintenir l’objectivité de son propos. Cependant, la science est faite par nous et cette démarche résiste plus ou moins bien à notre subjectivité, voir à notre honnêteté.
- Reposted by Jean-Charles LambertThe US Centers for Disease Control and Prevention (CDC) has mandated that all scientific manuscripts produced by its researchers that are under review at a journal be withdrawn so that certain language relating to gender can be stripped from them. go.nature.com/40YJGp4
- Reposted by Jean-Charles LambertReminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
- « La science a fait de nous des Dieux, avant même que nous soyons dignes d'être des hommes. » « Science has made us gods, even before we were worthy of being men. » Jean Rostand, biologist and science historian
- This morning I saw a panel of editorialists/gusets on a French news channel (@lciofficiel.bsky.social). They were completely fascinated by Trump, and completely detached from the impact of the current decisions. A lack of perspective without taking into account the feedback/fairs of many Americans.
- I compared ChatGT 4o mini and Deepseek on a specific scientific question about Alzheimer, which I know very well, and also asked for references. Deepseek's superiority is clear: more precise and the right references. On the reassuring side, I'm still better but I've spent years working on this :o)
- Many French editorialists believe that Munsk doesn't really have an ideology and that his support for the far right is just opportunism for his own business, with the aim of destabilizing the EU and its standards... seems naïve to me. He can be far-right and favor his business. Two birds, one stone
- Revision submitted last Friday and sent back for review 😔 I was really hoping for a quick and positive answer from the editor … Clearly less confident at present
- The post is in French, but I think it's pretty self-explanatory. Debating whether Musk did it or not seems superfluous to me. bsky.app/profile/slpn...
- After leaving X for good a few weeks ago, I've just deleted my Facebook account (which I wasn't using any more anyway). It won't have much impact but at least I feel consistent
- Reposted by Jean-Charles LambertFor #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy
- Urgent - following a withdrawal, we are looking for a research engineer/post-doctoral fellow (contract of at least two years) to take part in the transcriptomics/‘omics’ analyses of our Alzheimer's disease projects. Please do not hesitate to contact me!
- On Friday evening, we celebrated the departure of Dolores Siedlecki a post-doc who stayed with the lab for almost 5 years. For personal reasons, she's moving back to Spain. She was an important member of the team, both scientifically and on a human level. We'll miss her
- Reposted by Jean-Charles LambertExcited for this upcoming book publication by the great @charlespiller.bsky.social, about fraud in Alzheimer's research. I was fortunate to read the preprint, and it is SOOOO good! There will be several events in Washington DC and San Francisco, where Charles will introduce his book. /
- First review of my book, DOCTORED: FRAUD, ARROGANCE, AND TRAGEDY IN THE QUEST TO CURE ALZHEIMER’S, to be published Feb 4, out from Publisher’s Weekly: “hard-hitting exposé…troubling look at the corruption of Big Science.” Available for prerelease orders www.publishersweekly.com/9781668031247
